2023
DOI: 10.3390/biomedicines11071972
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Evaluation of Cx43 Gap Junction Inhibitors Using a Quantitative Structure-Activity Relationship Model

Abstract: Gap junctions (GJs) made of connexin-43 (Cx43) are necessary for the conduction of electrical impulses in the heart. Modulation of Cx43 GJ activity may be beneficial in the treatment of cardiac arrhythmias and other dysfunctions. The search for novel GJ-modulating agents using molecular docking allows for the accurate prediction of binding affinities of ligands, which, unfortunately, often poorly correlate with their potencies. The objective of this study was to demonstrate that a Quantitative Structure-Activi… Show more

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