Evaluation of CXCL10, CXCL11, CXCL12 and CXCL13 chemokines in serum and cerebrospinal fluid in patients with tick borne encephalitis (TBE)

Zajkowska, Joanna; Moniuszko, Anna; Pancewicz, Sławomir; Muszyńska-Mazur, A; Kondrusik, Maciej; Grygorczuk, Sambor; Swierzbińska-Pijanowska, Renata; Dunaj, Justyna; Czupryna, Piotr

doi:10.2478/v10039-011-0033-z

Cited by 67 publications

(61 citation statements)

References 21 publications

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“…TBEV stimulates IFNb expression in murine and human cells and the response to more pathogenic virus strains is stronger [29,36]. Type I IFNs expression during TBEV infection in vivo has not been studied so far, but we have previously detected increased concentrations of interferon-induced chemokine IP-10 in serum and csf of TBE patients, pointing to IFN-mediated response [37]. Here we confirm the IFNb up-regulation during TBE, from the early neurologic phase to the convalescence period.…”

Section: Polymorphismsupporting

confidence: 80%

Increased concentration of interferon lambda-3, interferon beta and interleukin-10 in the cerebrospinal fluid of patients with tick-borne encephalitis

et al. 2015

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Section: Polymorphismsupporting

confidence: 80%

Increased concentration of interferon lambda-3, interferon beta and interleukin-10 in the cerebrospinal fluid of patients with tick-borne encephalitis

et al. 2015

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“…T cells has been observed in the brains of fatal human TBEV cases [95,99]. Human TBE patients have elevated CCL3, CXCL10, and CXCL13 levels in the serum; CCL2, CCL3, CCL5, and CXCL10-13 have been detected in CSF, perhaps implicating the role of a Th-1-mediated response and the trafficking of T lymphocytes into the CNS [100][101][102]. Moreover, CCL2 and CCL5 were found to be elevated in the CSF of TBE patients even after the acute symptoms subsided [103,104].…”

Section: Tick-borne Encephalitis Virusmentioning

confidence: 98%

The role of chemokines in the pathogenesis of neurotropic flaviviruses

Bardina

Lim

2012

Immunol Res

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Neurotropic flaviviruses are important emerging and reemerging arthropod-borne pathogens that cause significant morbidity and mortality in humans and other vertebrates worldwide. Upon entry and infection of the CNS, these viruses can induce a rapid inflammatory response characterized by the infiltration of leukocytes into the brain parenchyma. Chemokines and their receptors are involved in coordinating complex leukocyte trafficking patterns that regulate viral pathogenesis in vivo. In this review, we will summarize the current literature on the role of chemokines in regulating the pathogenesis of West Nile, Japanese encephalitis, and tick-borne encephalitis virus infections in mouse models and humans. Understanding how viral infections trigger chemokines, the key cellular events that occur during the infection process, as well as the immunopathogenic role of these cells, are critical areas of research that may ultimately guide a much needed effort toward developing specific immunomodulators and/or antiviral therapeutics.

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“…In TBEV-infected patients presenting with neuroinvasive disease, two studies reported high levels of CXCL10 in the CSF (Lepej et al, 2007; Zajkowska et al, 2011); cytoanalysis of CSF samples revealed that the majority of CD4 + T-cells were positive for CXCR3. These data suggest that the CXCL10:CXCR3 axis may also be critical for T-cell migration into the CNS.…”

Section: The Role Of Chemokine Receptors In the Pathogenesis Of Arbovmentioning

confidence: 99%

Chemokine receptors as important regulators of pathogenesis during arboviral encephalitis

Michlmayr

Lim

2014

Front. Cell. Neurosci.

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The central nervous system (CNS) is a highly complex network comprising long-lived neurons and glial cells. Accordingly, numerous mechanisms have evolved to tightly regulate the initiation of inflammatory responses within the brain. Under neuroinflammatory conditions, as in the case of viral encephalitides, the infiltration of leukocytes is often required for efficient viral clearance and recovery. The orchestration of leukocyte migration into the inflamed CNS is largely coordinated by a large family of chemotactic cytokines and their receptors. In this review, we will summarize our current understanding of how chemokines promote protection or pathogenesis during arbovirus induced encephalitis, focusing on neurotropic flaviviruses and alphaviruses. Furthermore, we will highlight the latest developments in chemokine and chemokine receptor based drugs that could have potential as therapeutics and have been shown to play a pivotal role in shaping the outcome of disease.

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Evaluation of CXCL10, CXCL11, CXCL12 and CXCL13 chemokines in serum and cerebrospinal fluid in patients with tick borne encephalitis (TBE)

Cited by 67 publications

References 21 publications

Increased concentration of interferon lambda-3, interferon beta and interleukin-10 in the cerebrospinal fluid of patients with tick-borne encephalitis

Increased concentration of interferon lambda-3, interferon beta and interleukin-10 in the cerebrospinal fluid of patients with tick-borne encephalitis

The role of chemokines in the pathogenesis of neurotropic flaviviruses

Chemokine receptors as important regulators of pathogenesis during arboviral encephalitis

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