Evaluation of cyto-toxicity and corrosion behavior of alkali-heat-treated magnesium in simulated body fluid

Li, Longchuan; Gao, Jiacheng; Wang, Yong

doi:10.1016/j.surfcoat.2004.01.004

Cited by 427 publications

(224 citation statements)

References 9 publications

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“…The Osteoconductivity of magnesium is induced by the precipitation of calcium phosphate on the surface of the implants in an in vitro environment due to corrosion [86,87]. Biomimetic calcium phosphate coatings enhance osteoblast response, impart osteoconductive capacity, and reduce the healing time for bone defects.…”

mentioning

confidence: 99%

Porous magnesium-based scaffolds for tissue engineering

Yazdimamaghani

Razavi

Vashaee

et al. 2017

Materials Science and Engineering: C

241

115

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mentioning

confidence: 99%

Porous magnesium-based scaffolds for tissue engineering

Yazdimamaghani

Razavi

Vashaee

et al. 2017

Materials Science and Engineering: C

241

115

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“…The corrosion behaviour and cytotoxicity of alkali heat-treated pure Mg samples immersed in simulated body fluid (SBF) were investigated by Li et al [197]. The samples for treat ment were p laced into a super saturated NaHCO 3 -MgCO 3 solution and then heat-treated.…”

Section: Alkali Heat Treat Mentsmentioning

confidence: 99%

Biomedical Magnesium Alloys: A Review of Material Properties, Surface Modifications and Potential as a Biodegradable Orthopaedic Implant

Poinern¹,

Brundavanam²,

Fawcett³

2013

AJBE

283

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Magnesium and magnesium based alloys are lightweight metallic materials that are extremely biocompatib le and have similar mechanical properties to natural bone. These materials have the potential to function as an osteoconductive and biodegradable substitute in load bearing applicat ions in the field of hard t issue engineering. However, the effects of corrosion and degradation in the physiological environ ment of the body has prevented their wide spread applicat ion to date. The aim o f this review is to examine the properties, chemical stability, degradation in situ and methods of improving the corrosion resistance of magnesium and its alloys for potential application in the orthopaedic field. To be an effective imp lant, the surface and sub-surface properties of the material needs to be carefully selected so that the degradation kinetics of the implant can be efficiently controlled. Several surface modification techniques are presented and their effectiveness in reducing the corrosion rate and methods of controlling the degradation period are discussed. Ideally, balancing the gradual loss of material and mechanical strength during degradation, with the increasing strength and stability of the newly forming bone tissue is the ultimate goal. If this goal can be achieved, then orthopaedic implants manufactured fro m magnesium based alloys have the potential to deliver successful clinical outcomes without the need for revision surgery.

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“…Recently, Magnesium and its alloys emerged as promising candidates for biodegradable implant applications that do not require additional surgery for removal of implant after healing. Mg and its alloys are not only biocompatible but also contribute to the stimulation of bone growth and the healing process [4,5]. In addition, Mg-based materials have similar mechanical properties and Young's modulus compared with those of natural bone, avoiding a stress-shielding effect [6,7].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Corrosion Properties of Mg Matrix In Situ Composites Fabricated by Spark Plasma Sintering

Cao

Pham

Narita

et al. 2017

Metals

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Mg matrix in situ composites were fabricated from Mg and ZnO powder by a spark plasma sintering method. The composition and microstructure of the sintered samples were characterized. Corrosion properties of fabricated composites were evaluated by immersion and by electrochemical tests using Hanks' solution. The results showed that the formation of in situ products improved significantly the corrosion resistance of the fabricated composites compared with pure Mg; Mg-10 wt % ZnO composites especially exhibited the lowest corrosion rate. In addition, an energy-dispersive X-ray (EDX) analysis showed that calcium phosphate formed as a corrosion product on the surface of Mg-10 wt % ZnO composites, while Mg(OH)2 appeared as a corrosion product on the surface of Mg-20 wt % ZnO composite. The findings suggested Mg-10 wt % ZnO composite as a potential candidate for temporary implant application.

show abstract

Evaluation of cyto-toxicity and corrosion behavior of alkali-heat-treated magnesium in simulated body fluid

Cited by 427 publications

References 9 publications

Porous magnesium-based scaffolds for tissue engineering

Porous magnesium-based scaffolds for tissue engineering

Biomedical Magnesium Alloys: A Review of Material Properties, Surface Modifications and Potential as a Biodegradable Orthopaedic Implant

In Vitro Corrosion Properties of Mg Matrix In Situ Composites Fabricated by Spark Plasma Sintering

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