Evaluation of cytocompatibility and bending modulus of nanoceramic/polymer composites

McManus, Anastasia J.; Doremus, Robert H.; Siegel, Richard W.; Bizios, Rena

doi:10.1002/jbm.a.30204

Cited by 103 publications

(52 citation statements)

References 15 publications

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“…Previous studies have shown that the presence and size of nanoscale features on a material surface affect protein interactions [1] and thus subsequently modulate the functions of different cell types in specific manners [1,2]. For example, osteoblast adhesion is selectively enhanced on nanophase alumina, titania, and hydroxyapatite while fibroblast adhesion is suppressed on these materials [3].…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle-Decorated Surfaces for the Study of Cell-Protein-Substrate Interactions

Ballard

Dell'Acqua-Bellavitis

Bizios

et al. 2004

MRS Proc.

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The present study was motivated by the need for accurately-controlled and wellcharacterized novel bionaterial formulations for the study of cell-protein-material interactions. For this purpose, the current research has focused on the design, fabrication and characterization of model native oxide-coated silicon surfaces decorated with silica nanoparticles of select sizes, and has examined the adhesion of osteoblasts and fibroblasts on these nanoparticle-decorated surfaces. The results demonstrate the capability to deposit nanoparticles of select diameters and substrate surface coverage onto native silicon oxide-coated silicon, the firm attachment of these nanoparticles to the underlying native silicon oxide, and that nanoparticle size and coverage modulate adhesion of osteoblasts and fibroblasts to these substrates. The material formulations tested provide a well-controlled and well-characterized set of model substrates needed to study the effects of nanoscale features on the functions of cells that are critical to the clinical fate of implantable biomaterials.

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Section: Introductionmentioning

confidence: 99%

Nanoparticle-Decorated Surfaces for the Study of Cell-Protein-Substrate Interactions

Ballard

Dell'Acqua-Bellavitis

Bizios

et al. 2004

MRS Proc.

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“…Furthermore, the select preference and specific enhanced adhesion of osteoblasts was maintained only on composites of poly (L-lactic) acid (PLA) and nanophase (but not on polymer/conventional) ceramics (alumina, titania and hydroxylapatite) composites [4]. Specifically, osteoblast adhesion on the 50:50 (w:w)% PLA/nanophase alumina composite was similar to that obtained on 100% nanophase ceramic (the maximum observed in the study) In addition, these material formulations exhibited improved mechanical (specifically, bending modulus) properties [4].…”

Section: Cell Adhesionmentioning

confidence: 99%

Mammalian Cell Interactions with Nanophase Materials

Bizios

2004

MRS Proc.

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Adhesion of differentiated mammalian cells from various hard and soft tissues, including adult mesenchymal stem cells is different on nanophase than on microphase/conventional ceramics (such as alumina, titania and hydroxylapatite) as well as on composites of these ceramics with either poly(L-lactic) acid or poly(methyl) methacrylate. Most importantly, nanophase materials promote selective interactions, for example, of osteoblasts but not of fibroblasts. The type, amount and conformation of adsorbed proteins (such as fibronectin, collagen and vitronectin) are key aspects of the underlying mechanism(s) of subsequent cell interactions with nanophase materials. These cellular/molecular results provide evidence that nanophase biomaterials have the potential for improving the efficacy of implants and for promoting neotissue formation pertinent to tissue engineering, regenerative medicine and other clinical applications.

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“…19 Specifically, compared with a bending modulus of 60 ± 3 MPa for plain PLA and 870 ± 30 MPa for conventional titania/PLA composites with a weight ratio of 50/50, the bending modulus of nanophase titania/PLA composites with a weight ratio of 50/50 was 1960 ± 250 MPa. 19 In the paper, 19 the ceramic nanoparticles of varying amounts (30,40, and 50 wt%) were simply mixed with the polymers in organic solvents to compare the effect of the weight percentage of particles on the mechanical properties of the composites. The dispersion status of the nanoparticles was, however, not addressed.…”

Section: Introductionmentioning

confidence: 95%

“…17,18 Indeed, greater mechanical properties have been reported for polymer composites with a reduction in ceramic grain size into the nanometer range. 19 For example, McManus et al reported that the bending moduli of composites of PLA with 40 and 50 wt% nanophase (,100 nm) alumina, titania and HA were significantly greater than respective composite formulations with conventional coarser grained ceramics. 19 Specifically, compared with a bending modulus of 60 ± 3 MPa for plain PLA and 870 ± 30 MPa for conventional titania/PLA composites with a weight ratio of 50/50, the bending modulus of nanophase titania/PLA composites with a weight ratio of 50/50 was 1960 ± 250 MPa.…”

Section: Introductionmentioning

confidence: 99%

“…19 For example, McManus et al reported that the bending moduli of composites of PLA with 40 and 50 wt% nanophase (,100 nm) alumina, titania and HA were significantly greater than respective composite formulations with conventional coarser grained ceramics. 19 Specifically, compared with a bending modulus of 60 ± 3 MPa for plain PLA and 870 ± 30 MPa for conventional titania/PLA composites with a weight ratio of 50/50, the bending modulus of nanophase titania/PLA composites with a weight ratio of 50/50 was 1960 ± 250 MPa. 19 In the paper, 19 the ceramic nanoparticles of varying amounts (30,40, and 50 wt%) were simply mixed with the polymers in organic solvents to compare the effect of the weight percentage of particles on the mechanical properties of the composites.…”

Section: Introductionmentioning

confidence: 99%

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Mechanical properties of dispersed ceramic nanoparticles in polymer composites for orthopedic applications

Liu

Webster²

2010

IJN

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Ceramic/polymer composites have been considered as third-generation orthopedic biomaterials due to their ability to closely match properties (such as surface, chemistry, biological, and mechanical) of natural bone. It has already been shown that the addition of nanophase compared with conventional (or micron-scale) ceramics to polymers enhances bone cell functions. However, in order to fully take advantage of the promising nanometer size effects that nanoceramics can provide when added to polymers, it is critical to uniformly disperse them in a polymer matrix. This is critical since ceramic nanoparticles inherently have a strong tendency to form larger agglomerates in a polymer matrix which may compromise their properties. Therefore, in this study, model ceramic nanoparticles, specifically titania and hydroxyapatite (HA), were dispersed in a model polymer (PLGA, poly-lactic-co-glycolic acid) using high-power ultrasonic energy. The mechanical properties of the resulting PLGA composites with well-dispersed ceramic (either titania or HA) nanoparticles were investigated and compared with composites with agglomerated ceramic nanoparticles. Results demonstrated that well-dispersed ceramic nanoparticles (titania or HA) in PLGA improved mechanical properties compared with agglomerated ceramic nanoparticles even though the weight percentage of the ceramics was the same. Specifically, well-dispersed nanoceramics in PLGA enhanced the tensile modulus, tensile strength at yield, ultimate tensile strength, and compressive modulus compared with the more agglomerated nanoceramics in PLGA. In summary, supplemented by previous studies that demonstrated greater osteoblast (bone-forming cell) functions on well-dispersed nanophase ceramics in polymers, the present study demonstrated that the combination of PLGA with well-dispersed nanoceramics enhanced mechanical properties necessary for load-bearing orthopedic/dental applications.

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Evaluation of cytocompatibility and bending modulus of nanoceramic/polymer composites

Cited by 103 publications

References 15 publications

Nanoparticle-Decorated Surfaces for the Study of Cell-Protein-Substrate Interactions

Nanoparticle-Decorated Surfaces for the Study of Cell-Protein-Substrate Interactions

Mammalian Cell Interactions with Nanophase Materials

Mechanical properties of dispersed ceramic nanoparticles in polymer composites for orthopedic applications

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