Evaluation of cytotoxic activity of Syringodium isoetifolium against human breast cancer cell line - an in silico and in vitro study

Kalaivani, P.; Amudha, P.; Chandramohan, Anuradha; Vidya, R.; Prabhaharan, M.; Sasikumar, P.; Albukhaty, Salim; Sulaiman, Ghassan M.; Abomughaid, Mosleh M.; Abu-Alghayth, Mohammed

doi:10.1016/j.arabjc.2023.105179

Cited by 2 publications

(2 citation statements)

References 33 publications

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“…In our study, HUE induced intrinsic apoptosis, as indicated by the activation of caspase-3, the downregulation of the anti-apoptotic Bcl-2 protein, and the upregulation of the pro-apoptotic Bax protein ( Figure 5 ). This is in line with other studies reporting the pro-apoptotic effects of different seagrasses, Syringodium isoetifolium and Halophila ovalis , on the MCF-7 breast cancer cell line [ 61 , 63 ]. This is also similar to results obtained with other plant extracts, including Ziziphus nummularia and Origanum syriacum , on TNBC [ 25 , 77 ].…”

Section: Discussionsupporting

confidence: 92%

“…Previous studies have reported the anti-proliferative effects of H. uninervis extracts on different cancer cell lines [ 18 , 20 ]. It is worth noting that the anti-proliferative effects of different seagrasses, including Syringodium isoetifolium , Cymodocea serrulata , Halophila ovalis , and Halodule pinifolia (a different species of H. uninervis ), on the ER-positive breast cancer subtype are well documented [ 61 , 62 , 63 , 64 ]. However, this is the first study to assess the effects of H. uninervis ethanolic extract (HUE) on the triple-negative subtype of breast cancer.…”

Section: Discussionmentioning

confidence: 99%

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The Antioxidant Potential and Anticancer Activity of Halodule uninervis Ethanolic Extract against Triple-Negative Breast Cancer Cells

Wehbe,

Badran,

Baydoun

et al. 2024

Antioxidants

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Natural remedies have been indispensable to traditional medicine practices for generations, offering therapeutic solutions for various ailments. In modern times, these natural products continue to play a pivotal role in the discovery of new drugs, especially for cancer treatment. The marine ecosystem offers a wide range of plants with potential anticancer activities due to their distinct biochemical diversity and adaptation to extreme situations. The seagrass Halodule uninervis is rich in diverse bioactive metabolites that bestow the plant with various pharmacological properties. However, its anticancer activity against invasive triple-negative breast cancer (TNBC) is still poorly investigated. In the present study, the phytochemical composition of an ethanolic extract of H. uninervis (HUE) was screened, and its antioxidant potential was evaluated. Moreover, the anticancer potential of HUE against MDA-MB-231 cells was investigated along with the possible underlying mechanisms of action. Our results showed that HUE is rich in diverse phytochemicals that are known for their antioxidant and anticancer effects. In MDA-MB-231 cells, HUE targeted the hallmarks of cancer, including cell proliferation, adhesion, migration, invasion, and angiogenesis. The HUE-mediated anti-proliferative and anti-metastatic effects were associated with the downregulation of the proto-oncogenic STAT3 signaling pathway. Taken together, H. uninervis could serve as a valuable source for developing novel drugs targeting TNBC.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

The Antioxidant Potential and Anticancer Activity of Halodule uninervis Ethanolic Extract against Triple-Negative Breast Cancer Cells

Wehbe,

Badran,

Baydoun

et al. 2024

Antioxidants

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Seagrass Meadows: Prospective Candidates for Bioactive Molecules

Ameen,

Jayadev,

Prasad

et al. 2024

Molecules

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Seagrass meadows consist of angiosperms that thrive fully submerged in marine environments and form distinct ecosystems. They provide essential support for many organisms, acting as nursery grounds for species of economic importance. Beyond their ecological roles, seagrasses and their associated microbiomes are rich sources of bioactive compounds with the potential to address numerous human healthcare challenges. Seagrasses produce bioactive molecules responding to physical, chemical, and biological environmental changes. These activities can treat microbe-borne diseases, skin diseases, diabetes, muscle pain, helminthic diseases, and wounds. Seagrasses also offer potential secondary metabolites that can be used for societal benefits. Despite numerous results on their presence and bioactive derivatives, only a few studies have explored the functional and therapeutic properties of secondary metabolites from seagrass. With the increasing spread of epidemics and pandemics worldwide, the demand for alternative drug sources and drug discovery has become an indispensable area of research. Seagrasses present a reliable natural source, making this an opportune moment for further exploration of their pharmacological activities with minimal side effects. This review provides a comprehensive overview of the biochemical, phytochemical, and biomedical applications of seagrasses globally over the last two decades, highlighting the prospective areas of future research for identifying biomedical applications.

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Evaluation of cytotoxic activity of Syringodium isoetifolium against human breast cancer cell line - an in silico and in vitro study

Cited by 2 publications

References 33 publications

The Antioxidant Potential and Anticancer Activity of Halodule uninervis Ethanolic Extract against Triple-Negative Breast Cancer Cells

The Antioxidant Potential and Anticancer Activity of Halodule uninervis Ethanolic Extract against Triple-Negative Breast Cancer Cells

Seagrass Meadows: Prospective Candidates for Bioactive Molecules

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