Evaluation of cytotoxic, oxidative stress, proinflammatory and genotoxic effect of silver nanoparticles in human lung epithelial cells

Y, Al Omar Suliman; Ali, Daoud; Alarifi, Saud; Harrath, Abdel Halim; Mansour, Lamjed; Alwasel, Saleh

doi:10.1002/tox.21880

Cited by 102 publications

(72 citation statements)

References 39 publications

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“…Hence, the potential of AgEO-and AgCitrate-NP to trigger oxidative stress and subsequent DNA damage was analyzed in PBCEC and PCPEC. The potential of Ag-NPs to trigger oxidative stress and DNA damage has already been shown in many studies [5,20,29,34]. However, this has not yet been elucidated in barrier-forming cells of the CNS.…”

Section: Inflammatory Reaction In Pbcecmentioning

confidence: 99%

The Influence of Silver Nanoparticles on the Blood-Brain and the Blood-Cerebrospinal Fluid Barrier in vitro

Cramer¹,

Tacke²,

Bornhorst³

et al. 2014

J Nanomed Nanotechnol

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The use of silver nanoparticles in medical and consumer products such as wound dressings, clothing and cosmetic has increased significantly in recent years. Still, the influence of these particles on our health and especially on our brain, has not been examined adequately up to now. We studied the influence of AgEO-(Ethylene Oxide) and AgCitrate-Nanoparticles (NPs) on the protective barriers of the brain, namely the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (blood-CSF) barrier in vitro. The NPs toxicity was evaluated by examining changes in membrane integrity, cell morphology, barrier properties, oxidative stress and inflammatory reactions. AgNPs decreased cell viability, disturbed barrier integrity and tight junctions and triggered oxidative stress and DNA strand breaks. However, all mentioned effects were, at least partly, suppressed by a Citrate-coating and were most pronounced in the cells of the BBB as compared to the epithelial cells representing the blood-CSF barrier. AgEO-but not AgCitrate-NPs also triggered an inflammatory reaction in porcine brain capillary endothelial cells (PBCEC), which represent the BBB. Our data indicate that AgNPs may cause adverse effects within the barriers of the brain, but their toxicity can be reduced by choosing an appropriate coating material.

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Section: Inflammatory Reaction In Pbcecmentioning

confidence: 99%

The Influence of Silver Nanoparticles on the Blood-Brain and the Blood-Cerebrospinal Fluid Barrier in vitro

Cramer¹,

Tacke²,

Bornhorst³

et al. 2014

J Nanomed Nanotechnol

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“…The complementary advantages of the magnetic resonance imaging (MRI) and TPF in one nanoprobe can endow probes the ability of accurate positioning of the overall tumor in the body and the fine local details, which is attractive for the early diagnosis of tumors 6. Compared with the widely studied Au‐based NPs, Ag‐based NPs are seldom used in biomedical field, except for antimicrobial, mainly due to the serious cytotoxicity of Ag + released from Ag NPs 7. However, the unique properties of Ag NPs, such as special optical property, excellent electrical conductivity, good catalytic ability, bactericidal ability, and so on, are promising for biomedical application except their toxicity 8.…”

Section: Introductionmentioning

confidence: 99%

Galvanic Displacement Synthesis of Monodisperse Janus‐ and Satellite‐Like Plasmonic–Magnetic Ag–Fe@Fe₃O₄ Heterostructures with Reduced Cytotoxicity

Zhang

Yang

et al. 2018

Advanced Science

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The unique physicochemical properties of silver nanoparticles offer a large potential for biomedical application, however, the serious biotoxicity restricts their usage. Herein, nanogalvanic couple Ag–Fe@Fe3O4 heterostructures (AFHs) are designed to prevent Ag+ release from the cathodic Ag by sacrificial anodic Fe, which can reduce the cytotoxicity of Ag. AFHs are synthesized with modified galvanic displacement strategy in nonaqueous solution. To eliminate the restriction of lattice mismatch between Fe and Ag, amorphous Fe@Fe3O4 nanoparticles (NPs) are selected as seeds, meanwhile, reductive Fe can reduce Ag precursor directly even at as low as 20 °C without additional reductant. The thickness of the Fe3O4 shell can influence the amorphous properties of AFHs, and a series of Janus‐ and satellite‐like AFHs are synthesized. A “cut‐off thickness” effect is proposed based on the abnormal phenomenon that with the increase of reaction temperature, the diameter of Ag in AFHs decreases. Because of the interphase interaction and the coupling effect of Ag and Fe@Fe3O4, the AFHs exhibit unique optical and magnetic properties. This strategy for synthesis of monodisperse heterostructures can be extended for other metals, such as Au and Cu.

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“…In previous studies, the cytotoxic effects of AgNPs on cancer cells, along with the noncytotoxic effects of AuNPs, were similar to our findings. 26,27,[29][30][31] Suliman et al reported 32 AgNPs show less cytotoxicity on A549 cell compared with D-AgNPs at same concentration. Next, the synergistic effect between Dendropanax nanoparticles (silver and gold) and the ginsenoside CK was determined.…”

Section: In Vitro Cytotoxicity Of D-agnps and D-aunps In Lung Cancer mentioning

confidence: 99%

Rapid green synthesis of silver and gold nanoparticles using<em> Dendropanax morbifera</em> leaf extract and their anticancer activities

Kim¹,

Wang²,

Mathiyalagan³

et al. 2016

IJN

115

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Dendropanax morbifera Léveille is an oriental medicinal plant that is traditionally used in folk medicine and grows in a specific region of South Korea. We aimed to enhance the utilization of D. morbifera medicinal plants for synthesis of silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs). D. morbifera leaf extract acted as both a reducing and a stabilizing agent that rapidly synthesized Dendropanax AgNPs (D-AgNPs) and Dendropanax AuNPs (D-AuNPs). The D-AgNPs and D-AuNPs were characterized by ultraviolet-visible spectroscopy, energy dispersive X-ray analysis, elemental mapping, field emission transmission electron microscopy, X-ray diffraction, and dynamic light scattering. The characterizations revealed that the D-AgNPs and D-AuNPs were in polygon and hexagon shapes with average sizes of 100–150 nm and 10–20 nm, respectively. The important outcomes were the synthesis of AgNPs and AuNPs within 1 hour and 3 minutes, respectively, avoiding the subsequent processing for removal of any toxic components or for stabilizing the nanoparticles. Additionally, D-AgNPs and D-AuNPs were examined for cytotoxicity in a human keratinocyte cell line and in A549 human lung cancer cell line. The results indicated that D-AgNPs exhibited less cytotoxicity in the human keratinocyte cell line at 100 µg/mL after 48 hours. On the other hand, D-AgNPs showed potent cytotoxicity in the lung cancer cells at the same concentration after 48 hours, whereas D-AuNPs did not exhibit cytotoxicity in both cell lines at the same concentration. However, both D-AgNPs and D-AuNPs at 50 µg/mL enhanced the cytotoxicity of ginsenoside compound K at 25 µM after 48 hours of treatment compared with CK alone. We believe that this rapid green synthesis of D-AgNPs and D-AuNPs is a valuable addition to the applications of D. morbifera medicinal plant. D-AuNPs can be used as carriers for drug delivery and in cancer therapy due to their lack of normal cell cytotoxicity.

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Evaluation of cytotoxic, oxidative stress, proinflammatory and genotoxic effect of silver nanoparticles in human lung epithelial cells

Cited by 102 publications

References 39 publications

The Influence of Silver Nanoparticles on the Blood-Brain and the Blood-Cerebrospinal Fluid Barrier in vitro

The Influence of Silver Nanoparticles on the Blood-Brain and the Blood-Cerebrospinal Fluid Barrier in vitro

Galvanic Displacement Synthesis of Monodisperse Janus‐ and Satellite‐Like Plasmonic–Magnetic Ag–Fe@Fe₃O₄ Heterostructures with Reduced Cytotoxicity

Rapid green synthesis of silver and gold nanoparticles using<em> Dendropanax morbifera</em> leaf extract and their anticancer activities

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Evaluation of cytotoxic, oxidative stress, proinflammatory and genotoxic effect of silver nanoparticles in human lung epithelial cells

Cited by 102 publications

References 39 publications

The Influence of Silver Nanoparticles on the Blood-Brain and the Blood-Cerebrospinal Fluid Barrier in vitro

The Influence of Silver Nanoparticles on the Blood-Brain and the Blood-Cerebrospinal Fluid Barrier in vitro

Galvanic Displacement Synthesis of Monodisperse Janus‐ and Satellite‐Like Plasmonic–Magnetic Ag–Fe@Fe3O4 Heterostructures with Reduced Cytotoxicity

Rapid green synthesis of silver and gold nanoparticles using<em> Dendropanax morbifera</em> leaf extract and their anticancer activities

Contact Info

Product

Resources

About

Galvanic Displacement Synthesis of Monodisperse Janus‐ and Satellite‐Like Plasmonic–Magnetic Ag–Fe@Fe₃O₄ Heterostructures with Reduced Cytotoxicity