Comprehensive numerical studies, involving structural and Computational Fluid Dynamics (CFD) analysis, have been carried out at the Engineering Research Institute "Ventspils International Radio Astronomy Center" (VIRAC) of the Ventspils University College to investigate the gravitational and wind load effects on large, ground-based radio telescopes RT-32 performance. Gravitational distortions appear to be the main limiting factor for the reflector performance in everyday operation. Random loads caused by wind gusts (unavoidable at zenith) contribute to the fatigue accumulation.