Evaluation of Date Syrup as an Oral Negative Contrast Agent for MRCP

Govindarajan, Arunkumar; Lakshmanan, Prakash Manikka; Sarawagi, Radha; Prabhakaran, Velu

doi:10.2214/ajr.13.12299

Cited by 12 publications

(33 citation statements)

References 19 publications

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“…However, there are a few in vitro studies which can be comparable with the results of the present study. In the study by Govindarajan et al [1] with date syrup, despite the higher T2 effect resulted from the imaging parameters of the single-shot radial sequence, the SNR change of date syrup relative to water is similar to the signal suppression by grape syrup 30% for both sequences in our study. The finding shows the high efficiency of grape syrup for contrast-enhanced MRCP.…”

Section: Figure 2 Snr Of the Grape Syrup And The Grape Syrup/lemon Ssupporting

confidence: 40%

“…Magnetic resonance cholangiopancreatography (MRCP) is a non-invasive choice procedure for imaging the pancreatobiliary system with anatomic details and detecting different pathologies with high sensitivity and specificity [1]. It can be used as an alternative to endoscopic retrograde cholangiopancreatography (ERCP) due to its role in the detection of many biliary disorders [2].…”

Section: Introductionmentioning

confidence: 99%

“…However, the high signals from fluids in the gastrointestinal tract and other abdominal regions can overlap with the signals of the pancreatobiliary system and influence the diagnostic value of MRCP. Although using thin slices can partially help to solve the problem, due to the duodenum proximity to the pancreatobiliary system, the high signals may be problematic to find pathologies [1]. To overcome this condition, negative contrast agents are orally administered for fasting patients to provide the T2 shortening effect and to suppress the high signals produced by the gastrointestinal tract fluids [3].…”

Section: Introductionmentioning

confidence: 99%

“…Various natural substances such as pineapple juice [9], blueberry juice [10], lemon/orange juice [11], date syrup [1], Açai pulp and juice [12,13] black tea [14], and bananas [15] have been investigated for MRCP. The high concentrations of manganese and iron are responsible for the T2 shortening effect of oral negative contrast materials in MRCP [3].…”

Section: Introductionmentioning

confidence: 99%

“…Of various negative oral contrast agents, ferumoxsil, ferric ammonium citrate, and pineapple juice are among the most commonly used substances for MRCP [3]. However, less palatability of ferumoxsil [19], mild diarrhea with ferric ammonium citrate [8], and lower suppression of fluid signal in the gastrointestinal tract by pineapple juice comparing to ferumoxsil [1] are the problems with these contrast materials for MRCP. Therefore, investigation of the natural substances with potential for negative oral contrast agent can be conducted in order to improve the quality of MRCP images.…”

Section: Introductionmentioning

confidence: 99%

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Signal suppressions of grape syrup and grape syrup/lemon aqueous solutions in magnetic resonance cholangiopancreatography using heavily T2-weighted pulse sequence

Asgari

Divband

Gharehaghaji

2019

Polish Journal of Medical Physics and Engineering

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Signal suppression of the gastrointestinal tract fluids in magnetic resonance cholangiopancreatography (MRCP) has been performed using various natural and chemical substances with the different MRCP pulse sequences. This study aimed to investigate the signal suppressions of the grape syrup and the grape syrup/lemon aqueous solutions in MRCP using the heavily T2-weighted sequences. For this purpose, the potassium, iron and manganese contents of grape syrup were measured by atomic absorption spectroscopy. The grape syrup and the grape syrup/lemon solutions with the various grape syrup percentages were imaged using the heavily T2-weighted sequences of MRCP such as T2 HASTE thick slab and T2 SPACE. MRCP in the volunteers was performed before and 10 minutes after oral administration of the grape syrup solution. The concentrations of potassium, iron, and manganese in grape syrup were 34.8, 2.4 and 1 mg/l, respectively. The in vitro study showed significantly lower signal to noise ratio using the grape syrup samples comparing to the grape syrup/lemon. The effective signal suppression for the in vitro study and considerable enhancement of negative contrast in the post-contrast MRCP was obtained using a T2 HASTE thick slab sequence. As a conclusion, the grape syrup solution can be used for signal suppression of the gastrointestinal tract fluid in MRCP as an oral negative contrast material. A T2 HASTE thick slab sequence produces suitable contrast in MRCP images using the grape syrup solution.

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Section: Figure 2 Snr Of the Grape Syrup And The Grape Syrup/lemon Ssupporting

confidence: 40%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Signal suppressions of grape syrup and grape syrup/lemon aqueous solutions in magnetic resonance cholangiopancreatography using heavily T2-weighted pulse sequence

Asgari

Divband

Gharehaghaji

2019

Polish Journal of Medical Physics and Engineering

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Performance of a new natural oral contrast agent (LumiVision®) in dynamic MR swallowing

et al. 2021

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Objectives To evaluate image quality by first use of LumiVision® in dynamic MR swallowing, a contrast medium consisting of biological substances versus a gadolinium-buttermilk mixture in patients who underwent Nissen fundoplication due to gastroesophageal reflux disease (GERD). Methods The protocol of this retrospective study was approved by the local Institutional Review Board. A hundred twenty-nine patients (146 examinations) underwent a dynamic MR swallowing study (at 1.5 T or 3.0 T) and received an oral contrast agent. Two readers evaluated the distention of the esophagus, contrast, and traceability of the bolus in a 3-point scale. A steady-state coherent sequence (B-FFE, TrueFISP) was used. The patients were divided into 3 different groups: 53 patients received gadolinium chelate (Dotarem®)–buttermilk mixture (GBM) in a dilution of 1:40 as an oral contrast agent; 44 patients received LumiVision® water mixture (LWM) in a dilution of 1:1 and 49 patients received LumiVision® (L) undiluted. Results GBM showed significantly better results in overall evaluation for both readers in contrast to LWM (p = .003, p = .002). L also reached significantly better results in overall evaluation than LWM in both readers (p = .004, p = .042). There was no significant difference in the overall evaluation between L and GBM (p = .914, p = .376).According to Landis and Koch, interobserver agreement was “substantial” (Cohen’s kappa = 0.738) between both readers. Conclusion LumiVision® undiluted showed equal image quality compared to gadolinium-buttermilk mixture. The constellation of LumiVision® water mixture led to a clearly negative result in relation to the image quality compared to LumiVision® undiluted. Therefore, oral ingestion of LumiVision® undiluted is recommended for MR swallowing examinations. Key Points • LumiVision® undiluted shows significantly better image quality in comparison to LumiVision® diluted in oral application in swallowing MRI. • LumiVision® undiluted shows equal image quality in comparison to gadolinium-buttermilk mixture in oral application. • Oral ingestion of LumiVision® undiluted can replace gadolinium-buttermilk mixture in oral MR examinations.

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Performance survey on a new standardized formula for oral signal suppression in MRCP

Frisch

Walter

Grieser

et al. 2018

European Journal of Radiology Open

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Evaluation of Date Syrup as an Oral Negative Contrast Agent for MRCP

Abstract: Date syrup can be used as a negative oral contrast agent for gastrointestinal tract signal suppression during MRCP and for improving visualization of various pancreaticobiliary structures.

Cited by 12 publications

References 19 publications

Signal suppressions of grape syrup and grape syrup/lemon aqueous solutions in magnetic resonance cholangiopancreatography using heavily T2-weighted pulse sequence

Signal suppressions of grape syrup and grape syrup/lemon aqueous solutions in magnetic resonance cholangiopancreatography using heavily T2-weighted pulse sequence

Performance of a new natural oral contrast agent (LumiVision®) in dynamic MR swallowing

Performance survey on a new standardized formula for oral signal suppression in MRCP

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