Hypocryphalus mangiferae Stebbing is one of the most destructive insect pests of mango trees and is found to be associated with the transmission of causal organisms of mango sudden death disease. The present study was carried out to evaluate the toxicity of deltamethrin, bifenthrin, chlorpyrifos, emamectin benzoate, imidacloprid and spinosad in laboratory and field trials. Bioassay results showed that the toxicity of chlorpyrifos was significantly higher than deltamethrin but similar to bifenthrin. Deltamethrin and bifenthrin toxicity, however, increased significantly (P < 0.01) from day 1 to day 3. Spinosad was the least toxic compound while emamectin was the most toxic among new chemical insecticides tested, but its toxicity increased significantly from day 1 to day 5. Comparison of the efficacies of the insecticides using lethal times to produce 50% mortality (LT50) and 90% mortality (LT90) showed that the relative potencies of chlorpyrifos, emamectin, imidacloprid and spinosad were greater than bifenthrin and deltamethrin. The results of field trials showed the highest number of beetles emerged from the control twigs while significantly fewer beetles emerged from the twigs treated with bifenthrin (P < 0.05), which accounted for 12% for bifenthrin compared to that of the control. The present study demonstrated increased toxicities of systemic insecticides and chlorpyrifos compared to toxicities of deltamethrin and bifenthrin, suggesting these insecticides could be an alternative tool in a comprehensive H. mangiferae management program to eradicate the beetles from mango orchards.