Evaluation of Depression and Quality of Life in Patients With Psoriasis

Abstract

Objective: To measure the prevalence of depression in patients with psoriasis and to evaluate the relationship between the severity of psoriasis and depression and its effect on patients' quality of life. Methods: A total of 154 patients with a confirmed diagnosis of psoriasis were assessed to determine the severity of psoriasis based on the psoriasis area and severity index score, presence, and severity of depression using the patient health questionnaire 9, and quality of life using the dermatology life quality index 10. Pearson correlation coefficient was used to demonstrate the relationship between continuous variables with 95% confidence intervals (CIs); P < 0.00001 was taken to indicate statistical significance. Results: The severity of psoriasis was mild in 36.36% of patients, moderate in 25.97%, severe in 32.47%, and very severe in 5.20%. Of the 154 patients, 139 (90.3%) had depression; the severity of depression was mild in most affected patients (46.7%) and severe in 2.6% of patients. Psoriasis had a moderate effect on the quality of life in 37.01% of patients and a very large effect in 33.77% of patients. The severity of psoriasis was positively correlated with depression (Pearson correlation coefficient, r = 0.42, P<0.00001, 95% CI: 0.28-0.54) and quality of life (r = 0.43, P<0.00001, 95% CI: 0.29-0.55). Conclusion: Depression is a common comorbidity in patients with psoriasis. The severity of psoriasis is positively correlated with the severity of depression and is associated with poor quality of life.

Patient Perspectives of the Impact of Psoriatic Disease on Quality-of-Life in India: Sub-analysis from the Global Psoriasis and Beyond Survey

“…[ 12 ] A prospective observational study from India also found a similar proportion of severe/very severe patients with PsO (37.7%). [ 14 ] Legs (69%), fingers (48%), scalp, knees, and neck (46% each) were the predominant sites involved in this analysis. These findings are in line with studies published across the Indian subcontinent, reporting lower limbs (78%),[ 11 ] trunk and limbs (70% each),[ 4 ] and scalp and extremities (74%),[ 15 ] as the most common sites of PsO in India.…”

“…Nonetheless, observational studies from India reported that PsO had a very-large effect on QoL in 34–35% of patients when determined through DLQI. [ 14 17 ] In contrast, a cross–sectional observational study from India found that PsO had a very-large effect on QoL in 70% of patients. [ 18 ] A prospective observational study from India including 154 patients with PsO found that 90.3% patients had depression.…”

“…[ 18 ] A prospective observational study from India including 154 patients with PsO found that 90.3% patients had depression. [ 14 ] Age, marital status, educational status, working status, and severity of PsO were significantly impacting depression in these patients. [ 14 ] Mathew et al .…”

“…[ 14 ] Age, marital status, educational status, working status, and severity of PsO were significantly impacting depression in these patients. [ 14 ] Mathew et al . included 80 patients with PsO and concluded that patients with higher severity of disease were associated with higher disability, both physically and mentally, along with increased stress.…”

Thymic Stromal Lymphopoietin Activates Mouse Dendritic Cells Through the JAK/SYK Pathway in Promoting Th17 Response in Psoriasis

“…Although psoriasis is primarily a skin disease, it has been shown to influence the mental health impact of those affected. 1 , 2 , 3 Histologically, psoriasis is characterized by epidermal thickness and downward elongation of the rete ridges. The granular layer becomes thinner or disappears, capillaries elongate and dilate, and T cells enter the dermis and epidermis.…”