Evaluation of developmental toxicity in rats exposed to the environmental estrogen bisphenol A during pregnancy

Kim, Jong-Choon; Shin, Ho‐Chul; Cha, Shin‐Woo; Koh, Woo-Suk; Chung, Moon-Koo; Han, Sangsoo

doi:10.1016/s0024-3205(01)01341-8

Cited by 116 publications

(86 citation statements)

References 38 publications

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“…Reduced fetal survival and body weights at birth or during the postnatal period were reported in studies with oral exposures occurring throughout the entire gestation and/or lactation periods (Tyl et al, 2000a(Tyl et al, , 2002bKim et al, 2001b). LOAELs for decreased numbers of live fetuses or pups ranged from 475-1000 mg/kg bw/day (Tyl et al, 2000a(Tyl et al, , 2002bKim et al, 2001b). LOAELs for decreased pup body weight at birth were estimated at 300-1000 mg/kg bw/day (Tyl et al, 2000a(Tyl et al, , 2002bKim et al, 2001b).…”

Section: Experimental Animal Studies Considered Bymentioning

confidence: 95%

“…Rat Studies: Prenatal studies with oral dosing of rats consistently demonstrated an absence of malformations at doses up to 1000 mg/kg bw/day (Morrissey et al, 1987;Kim et al, 2001b). Reduced fetal survival and body weights at birth or during the postnatal period were reported in studies with oral exposures occurring throughout the entire gestation and/or lactation periods (Tyl et al, 2000a(Tyl et al, , 2002bKim et al, 2001b).…”

Section: Experimental Animal Studies Considered Bymentioning

confidence: 99%

“…Kim et al (2001b), support not indicated, examined the effects of prenatal bisphenol A exposure on developmental toxicity in rats. Sprague-Dawley rats were fed commercial rodent chow (Jeil Feed Co., Daejon, Korea) and housed in polycarbonate cages; no information was provided about bedding.…”

Section: Experimental Animalmentioning

confidence: 99%

“…LOAELs for decreased numbers of live fetuses or pups ranged from 475-1000 mg/kg bw/day (Tyl et al, 2000a(Tyl et al, , 2002bKim et al, 2001b). LOAELs for decreased pup body weight at birth were estimated at 300-1000 mg/kg bw/day (Tyl et al, 2000a(Tyl et al, , 2002bKim et al, 2001b). The LOAEL for reduced body weight during the postnatal period was 475 mg/kg bw/day (Tyl et al, 2000a(Tyl et al, , 2002b.…”

Section: Experimental Animal Studies Considered Bymentioning

confidence: 99%

See 3 more Smart Citations

NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

Chapin

Adams

Boekelheide

et al. 2008

Birth Defects Research Pt B

404

304

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Section: Experimental Animal Studies Considered Bymentioning

confidence: 95%

Section: Experimental Animal Studies Considered Bymentioning

confidence: 99%

Section: Experimental Animalmentioning

confidence: 99%

Section: Experimental Animal Studies Considered Bymentioning

confidence: 99%

See 2 more Smart Citations

NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

Chapin

Adams

Boekelheide

et al. 2008

Birth Defects Research Pt B

404

304

View full text Add to dashboard Cite

“…Previous study showed that BPA administered orally at gestational stage of rats could detect not only in maternal tissues but also in fetuses, 9) indicating that BPA in maternal animals could be transferred to fetuses in gestation. Kim et al 10) reported that the administration of 1000 mg/kg of BPA to pregnant rats occasionally induced the pregnancy failure, but 300 mg/kg of BPA did not induce these effects on fetuses. In the present study, the amount of BPA in 1% BPA diet is equal to 1000 mg/kg of BPA, and the number of live fetuses per litter in BPA diet group was same to that in normal diet group.…”

Section: Influence Of Dietary Bisphenol a On The Growth Of Newborn Pupsmentioning

confidence: 99%

Dietary Bisphenol A Suppresses the Growth of Newborn Pups by Insufficient Supply of Maternal Milk in Mice

Matsumoto

Miyaura

Ito

2004

JOURNAL OF HEALTH SCIENCE

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Bisphenol A (BPA), a monomer used for the production of polycarbonate, is known to have estrogen activity. In this study, pregnant mice were fed chow diet containing 1% BPA, and we examined the influence of dietary BPA on delivery and growth of newborn pups in mice. When pregnant mice were fed BPA diet, the mice normally delivered pups on day 21 of gestation. The number of offspring pups in maternal mice fed BPA diet was same to those fed normal diet. Therefore, the growth of fetuses and the process of delivery were not influenced by dietary BPA. However, the growth of newborn pups was markedly suppressed when maternal mice were fed BPA diet. The growth of neonatal mice depends on breast milk, and stomach was filled with milk in pups. In newborn pups from maternal mice supplemented with BPA diet, the weight of stomach was lower than that from maternal mice with normal diet. Since the serum level of prolactin was limited in maternal mice supplemented with BPA diet, the suppressed growth of newborn pups by dietary BPA may be due to the insufficient supply of breast milk. These results suggest that the influence of BPA on the growth of newborn pups is related to hormonal condition in maternal mice.Key words ---bisphenol A, breast milk, growth of pups, prolactin INTRODUCTIONBisphenol A (BPA) is a class of monomer widely used in the production of polycarbonate plastic products. The level of human exposure to BPA is not insignificant, as microgram amounts of BPA were reported to be detectable in liquid from canned vegetables.1) Since children are thought to be more sensitive to endocrine disrupters including BPA than adults, the influence of the exposure of BPA may depend on age and hormonal condition. BPA binds to estrogen receptor with approximately 10000 times less affinity than 17β-estradiol and it exhibits estrogenic activity both in vitro and in vivo assay systems.2) In vivo assay, BPA enhances the uterine weight in immature animals, and accelerate the onset of puberty.3) It is known that BPA exhibits estrogenic properties in sexual organs, but the effects of BPA in vivo are still not clear.Estrogens are synthesized from androgens by aromatase (CYP19). 4) We have reported that aromatase-deficient (ArKO) mice show underdeveloped uteri and mammary gland, bone loss by increased bone resorption and abnormal lipid metabolism.5-7) All of these phenotypes in ArKO mice are due to estrogen deficiency caused by loss of aromatase, and the replacement of estrogen restore these phenotypes to normal. When ArKO were fed chow diet supplemented with 0.1% or 1% BPA, they were protected from ovarian degeneration, uterine diminution and bone loss in a dose-dependent manner.8) Therefore, estrogenic effects of BPA on the reproductive tract as well as skeletal tissue were evident in adult female ArKO mice. Since ArKO mice completely lose estrogen synthesis, ArKO is a useful animal model for characterization of estrogenic compounds. However, the influence of estrogenic compounds in normal animal may be related to the hormonal condition...

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Bisphenol A [MAK Value Documentation in German language, 2011]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 50. Lieferung, Ausgabe 2011 Der Artikel enthält folgende Kapitel: Wirkungsmechanismus Endokrine Wirkung Wirkung auf den Zellzyklus Toxikokinetik und Metabolismus Inhalative Exposition Orale Aufnahme Dermale Aufnahme Erfahrungen beim Menschen Hautsensibilisierende Wirkung Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Fertilität Entwicklungstoxizität Pränatale Entwicklungstoxizität Postnatale Entwicklungstoxizität Wirkung auf die Entwicklung männlicher Nachkommen: Wirkung auf die Entwicklung weiblicher Nachkommen: Postnatale Verhaltensänderungen: Genotoxizität In vitro In vivo Kanzerogenität Bewertung

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Evaluation of developmental toxicity in rats exposed to the environmental estrogen bisphenol A during pregnancy

Cited by 116 publications

References 38 publications

NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

Dietary Bisphenol A Suppresses the Growth of Newborn Pups by Insufficient Supply of Maternal Milk in Mice

Bisphenol A [MAK Value Documentation in German language, 2011]

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