Evaluation of Developmental Toxicity of Amitraz in Sprague-Dawley Rats

Kim, Joochan; Shin, Jae‐Ho; Yang, Young-Su; Shin, Dong–Ho; Moon, Changjong; Kim, S H; Park, S C; Kim, Y B; Kim, Hyoung-Chin; Chung, Moon-Koo

doi:10.1007/s00244-006-0021-7

Cited by 35 publications

(25 citation statements)

References 28 publications

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“…In this study, although several types of visceral and skeletal variations were observed in the fetuses in all groups, fetal malformations were not observed in any of the fetuses from the dams exposed to the polycarbonate, concrete, and hwangto building environments. Moreover, since these findings were distributed evenly between the groups and were consistent with the normal range of historical control rat fetuses (Kim et al, 2001;MARTA 1997;Morita et al, 1987), the fetal variations observed in the concrete and hwangto groups were not considered to be exposure-related effects.…”

Section: Discussionsupporting

confidence: 58%

“…On the other hand, all the rats in the hwangto groups were also exposed continuously to similar lowtemperature environments during pregnancy but they did not show any adverse effects on embryo-fetal development. Moreover, all the Caesarean section data were within the limits of normal biological variations (Kim et al, 2001;MARTA 1997;Morita et al, 1987). These results suggest that although there were some adverse effects on embryo-fetuses observed in the concrete group when exposed continuously to low temperatures in the winter, the hwangto building environment can prevent the potential adverse effects of low-temperature environment on embryo-fetal development.…”

Section: Discussionmentioning

confidence: 57%

“…Although a statistically significant difference was not detected, the increased number of fetal deaths observed in the concrete group is also considered to be an exposure-related effect. This is because there was a much higher (3-4 times) number of fetal deaths in the concrete group than in the control group, and the value was beyond the limits of the historical control rat fetuses (Kim et al, 2001;MARTA 1997;Morita et al, 1987). The increase in the number of early embryonic resorptions suggests that an interruption in pregnancy occurred mainly during the embryonic developmental stage but not in the fetal developmental stage.…”

Section: Discussionmentioning

confidence: 95%

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Evaluation of embryo‐fetal development in rats housed in concrete or hwangto cages during pregnancy

Lee¹,

Ahn²,

Yang³

et al. 2008

Birth Defects Research Pt B

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BACKGROUND:Recently, it was reported that the 4-week exposure of rats to a concrete building environment under cool temperatures (11.7-12.11C) had adverse effects on the general health parameters. This study examined the potential effects of concrete and hwangto building environments on pregnant dams and embryo-fetal development in SpragueDawley rats. METHODS: Groups of 10 mated females were exposed to polycarbonate (control), concrete, or hwangto cages from gestational days (GD) 0 to 20 under cool temperatures (11.9-12.51C). All the females underwent a caesarean section on GD 20, and their fetuses were examined for any morphological abnormalities. RESULTS: The temperatures in the cages were similar in all groups but the relative humidity in the concrete and hwangto groups were higher than in the control group. The concentration of volatile organic compounds in the hwangto group during the study period was lower than in the control group. In the concrete group, maternal effects manifested as an increase in the incidence of clinical signs, a lower body weight, and a decrease in the thymus and ovary weights. Developmental effects included increased post-implantation loss and decreased litter size. In contrast, in the hwangto group, there were no exposurerelated adverse effects on the maternal and developmental parameters. CONCLUSIONS: Overall, the exposure of pregnant rats to a concrete building environment under cool temperatures has adverse effects on the clinical signs, body weight, organ weight, and embryo-fetal development. On the other hand, exposure to a hwangto building environment does not have any adverse effects on pregnant dams or on embryo-fetal development in rats. Birth Defects Res (Part B) 83: 32-39, 2008.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 95%

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Evaluation of embryo‐fetal development in rats housed in concrete or hwangto cages during pregnancy

Lee¹,

Ahn²,

Yang³

et al. 2008

Birth Defects Research Pt B

Self Cite

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show abstract

“…A resorption site was defined as an implantation site resembling a brown to greenish blood clot, with the placental tissue (early resorption) or placental and embryonic tissue (late resorption). 26 Each fetus was removed from the placenta, weighed and the crown rump (CR) length was recorded. Fetuses were examined for external malformation and variation.…”

Section: Assessment Of Fertilitymentioning

confidence: 99%

The effects ofN-acetyl-l-cysteine on the female reproductive performance and nephrotoxicity in rats

Helal

2016

Renal Failure

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This study was designed to investigate whether the treatment with the N-acetyl-L-cysteine prior to the administration of chemotherapy drug would prevent from nephrotoxicity and the loss of reproductive performance induced from chemotherapy treatment. Female rats were divided into five equal groups of six each: 1/control group; 2/rats i.p administered saline solution; 3/rats i.p administered holoxan (50 mg/kg b.wt); 4/rats i.p administered N-acetyl-L-cysteine (160 mg/kg b.wt); 5/rats i.p administered holoxan and N-acetyl-L-cysteine at the same doses. After medications, females rats were allowed to mate with males and the pregnant rats were sacrificed on day 18 of gestation. Premating treatment with holoxan showed reduction (p50.05) in reproductive performance. Whereas administration of N-acetyl-L-cysteine prior to treatment with holoxan and then concurrently with it modulated significantly fertility index, progesterone level, decreasing postimplantation loss, resorbed fetuses and improved fetal growth. Additionally, holoxan elevated the renal nicotinamide dinucleotide phosphate (NADPH) oxidase activity, oxidative stress, renal functions and caused histological changes in renal tissue. N-Acetyl-L-cysteine treatment reduced (p50.05) renal tissue NADPH oxidase, nitric oxide, malondialdehyde and improved super oxide dismutase (SOD) depletion, elevated levels phosphate, total protein and calcium as well as prevented renal histological damages. N-Acetyl-L-cysteine can confer protection against nitrosative and oxidative stresses in renal tissue induced by holoxan by suppressing NADPH oxidase activation, malondialdehyde, nitric oxide and restoring SOD activity which led to the reduction of reactive oxygen species production and subsequently might effectively improve the gonadal hormone disturbance and reproductive functions. ARTICLE HISTORY

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“…A resorption site was defined as an implantation site resembling a brown to greenish blood clot, with just placental tissue (early resorption) or placental and embryonic tissue (late resorption). 21 A non-viable fetus was described as a fetus that does not react to stimuli, has a pale color, stemming from a lack of blood flow, and is smaller in size compared to the viable fetuses. Both ovaries were excised, trimmed of excess tissue, and the number of corpora lutea was counted.…”

Section: Mating Studiesmentioning

confidence: 99%

Reproductive Toxic Effects of Cisplatin and Its Modulation by the Antioxidant Sodium 2-Mercaptoethanesulfonate (Mesna) in Female Rats

Yeh¹,

Kim²,

Peresie³

2011

Reproductive Biology Insights

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Study Objective: Chemical protection against cisplatin, which is a commonly used cancer chemotherapeutic agent, is not well defined. We tested the hypothesis that the antioxidant mesna might protect against the cisplatin-induced repoductive effects in female rats. Design & Setting: Adult female rats were injected with saline, cisplatin alone, or mesna + cisplatin, mated with males, and euthanized on gestational day 17. Patients: Animal Model. Interventions: The administration of either cisplatin or mesna + cisplatin (two injections one week apart, mesna 30 minute pretreatment) followed by mating one week after treatment. Main Outcomes Measured:The number corpora lutea, implantation and resorptions sites, viable and non-viable fetuses, fetal weights, and the level of progesterone per corpus luteum. Results: The administration of cisplatin caused an increase in pre-and post-implantation loss, an increase in the number of resorptions and a decrease in the number of viable fetuses. Mesna administered prior to cisplatin resulted in a decrease in the rate of the pre-and post implantation loss, along with a decrease in the number of resorptions and an increase in the number of live fetuses. Conclusions: Prior exposure to cisplatin caused significant adverse effects on fertility as evidenced by the decreased implantation due to increased fetal loss. The administration of mesna appeared to temper cisplatin damage by lessening the cisplatin effects on fetal resorption.

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Evaluation of Developmental Toxicity of Amitraz in Sprague-Dawley Rats

Cited by 35 publications

References 28 publications

Evaluation of embryo‐fetal development in rats housed in concrete or hwangto cages during pregnancy

Evaluation of embryo‐fetal development in rats housed in concrete or hwangto cages during pregnancy

The effects ofN-acetyl-l-cysteine on the female reproductive performance and nephrotoxicity in rats

Reproductive Toxic Effects of Cisplatin and Its Modulation by the Antioxidant Sodium 2-Mercaptoethanesulfonate (Mesna) in Female Rats

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