Evaluation of Device-associated Nosocomial Infections in A Paediatric Intensive Care Unit

Çevik, Saliha; Tekin, Recep; Gündeşli̇oğlu, Özlem Özgür; Aktar, Fesih; Yilmaz, Ş M; Ay, Mejgal

doi:10.7727/wimj.2014.231

Cited by 4 publications

(4 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…3 Despite increased medical and technological facilities, the mortality rate of health care-associated Acinetobacter infections is considerably higher. [12][13][14][15][16] Mortality rates associated with A. baumannii have been reported in 13.9 to 83%. 17 In this study, mortality rates were statistically significantly higher in XDRABIs (54.3%) than control group (2.5%) (p < 0.001).…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Extensively Drug-Resistant Acinetobacter baumannii in Neonatal Patients

Tekin

Yolbaş

Bozkurt³

et al. 2020

Journal of Pediatric Infectious Diseases

View full text Add to dashboard Cite

Introduction Extensively drug-resistant Acinetobacter baumannii infections (XDRABIs) are significant causes of mortality and morbidity in neonatal patients due to the treatment difficulties and limitations. In the present study, we aimed to evaluate the characteristics and risk factors for XDRABIs acquisition during hospitalization. Methods We investigated the risk factors of health care-associated infections (HC-AIs) caused by multidrug-resistant A. baumannii in the four neonatal units between January 2008 and December 2018. The patients and the control group's data and culture results were recorded and analyzed on a daily basis. Results A total of 70 patients infected with XDRABIs and 118 control patients were included in the study. Univariate analysis showed that prematurity, gestation age, birth weight, mechanical ventilation, parenteral nutrition, transfusion, use of glycopeptides, and aminoglycosides were significantly associated with XDRABIs. In the univariate analysis, gestation age, mechanical ventilation, transfusion, parenteral nutrition, use of glycopeptides, carbapenems, and aminoglycosides were significantly associated with mortality. In the multiple logistic regression analysis, gestation age (p = 0.034), transfusion (p < 0.001), and use of glycopeptides (p = 0.019) were determined to be independent predictors of mortality in newborn infants with XDRABIs (R-square = 0.546). Conclusion Determination of the risk factors, avoiding invasive procedures, rational use of antibiotics will lead to a decrease in the mortality and morbidity rates related to XDRABIs.

show abstract

Section: Discussionmentioning

confidence: 99%

Risk Factors for Extensively Drug-Resistant Acinetobacter baumannii in Neonatal Patients

Tekin

Yolbaş

Bozkurt³

et al. 2020

Journal of Pediatric Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…2 Nozokomiyal enfeksiyonlar arasında en sık görülen kan dolaşımı enfeksiyonlarıdır (KDE). 5,7 Ülkemizde nozokomiyal enfeksiyonlar içerisinde KDE görülme oranları %7,6-30,2'dir. 5 Literatürde arteriyel ve santral venöz kateterizasyon, parenteral beslenme, mekanik ventilasyon, kan transfüzyonu, nötropeni ve malignite varlığının nozokomiyal KDE riskini artırdığı gösterilmiştir.…”

Section: Introductionunclassified

Incidence and Risk Factors of Nosocomial Bloodstream Infections in Pediatric Intensive Care Unit

Akgül¹,

Arslan²,

Karaarslan³

et al. 2021

cayd

View full text Add to dashboard Cite

Kan dolaşımı enfeksiyonları (KDE) hastanede yatış süresinde uzamaya, tedavi maliyetlerinde ve mortalite oranlarında artışa yol açması nedeniyle yoğun bakım ünitelerinin (YBÜ) en önemli sorunlarındandır. Bu çalışmada çocuk yoğun bakımda nozokomiyal KDE sıklığı ve risk faktörlerinin saptanması, en sık görülen mikroorganizmaların belirlenmesi amaçlanmıştır. Yöntemler: Dokuz Eylül Üniversitesi Çocuk YBÜ'de Ocak 2011-Ocak 2013 tarihlerinde 48 saatten uzun süre yatarak tedavi edilen hastalar incelendi. Nozokomiyal KDE geçiren olgular belirlenerek yatış süresince nozokomiyal enfeksiyon geçirmeyen olgularla demografik veriler, yatış tanıları ve altta yatan süreğen hastalıkları, invaziv girişimler ve tedaviler açısından karşılaştırıldı. Kan kültüründe izole edilen mikroorganizmalar kaydedildi. Bulgular: Çalışmaya alınan 252 hastada toplam 58 KDE epizotu saptandı. Olguların %55'i erkek (E/K: 1,2) olup ortanca yaş 10 aydı. Nozokomiyal KDE sıklık hızı 14,7/1,000 hasta günü olarak hesaplandı. Yoğun bakım yatışından ortanca 16,5 gün sonra KDE geliştiği tespit edildi. Altta yatan doğuştan kalp hastalığı, metabolik hastalık, nörolojik hastalık veya genetik sendrom varlığında ve santral venöz kateterizasyon ve mekanik ventilasyon uygulanan hastalarda daha sık nozokomiyal KDE gözlendi. Genetik sendrom varlığı ve yoğun bakımda yatış süresinin uzaması KDE gelişimi için bağımsız risk faktörü olarak saptandı. En sık izole edilen etkenler koagülaz negatif Stafilokoklar (%48), Klebsiella spp. (%24), Enterobacter spp. (%9), Candida spp. (%9) olarak belirlendi. Sonuç: Nozokomiyal KDE için risk faktörlerinin belirlenerek bu doğrultuda önlemlerin alınması tedavi maliyetlerinin ve mortalitenin azaltılabilmesi açısından özellikle önemlidir. Yoğun bakımda geçirilen gün sayısı arttıkça risk arttığı için yatış süreleri mümkün olduğunca kısa tutulmalıdır.

show abstract

“…Microbial colonization of an indwelling device may result in surrounding tissue destruction, systemic spreading of pathogen followed by serious illness and death . These infections are predominantly caused by Gram‐positive bacteria such as staphylococci or Gram‐negative bacteria such as Pseudomonas aeruginosa . Microbial adhesion can result to biofilm formation in which cells are embedded within a self‐produced extracellular substance in association with a solid surface .…”

Section: Introductionmentioning

confidence: 99%

“…7 These infections are predominantly caused by Gram-positive bacteria such as staphylococci or Gram-negative bacteria such as Pseudomonas aeruginosa. 2,8,9 Microbial adhesion can result to biofilm formation in which cells are embedded within a self-produced extracellular substance in association with a solid surface. 10 Biofilm formation and persistence has a significant impact on patient care and management because microorganisms in biofilms are significantly resistant to host defense systems and antibiotic treatment.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of immobilized lactoferrin and lactoferricin

et al. 2016

View full text Add to dashboard Cite

Lactoferrin and lactoferricin were immobilized on glass surfaces via two linkers, 4-azidobenzoic acid (ABA) or 4-fluoro-3-nitrophenyl azide (FNA). The resulting surfaces were characterized by X-ray photoelectron spectroscopy (XPS) and contact angle measurements. The antimicrobial activity of the surfaces was determined using Pseudomonas aeruginosa and Staphylococcus aureus strains by fluorescence microscopy. Lactoferrin and lactoferricin immobilization was confirmed by XPS showing significant increases (p < 0.05) in nitrogen on the glass surface. The immobilization of both proteins slightly increased the overall hydrophobicity of the glass. Both lactoferrin and lactoferricin immobilized on glass significantly (p < 0.05) reduced the numbers of viable bacterial cells adherent to the glass. For P. aeruginosa, the immobilized proteins consistently increased the percentage of dead cells compared to the total cells adherent to the glass surfaces (p < 0.03). Lactoferrin and lactoferricin were successfully immobilized on glass surfaces and showed promising antimicrobial activity against pathogenic bacteria. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2612-2617, 2017.

show abstract

Evaluation of Device-associated Nosocomial Infections in A Paediatric Intensive Care Unit

Cited by 4 publications

References 16 publications

Risk Factors for Extensively Drug-Resistant Acinetobacter baumannii in Neonatal Patients

Risk Factors for Extensively Drug-Resistant Acinetobacter baumannii in Neonatal Patients

Incidence and Risk Factors of Nosocomial Bloodstream Infections in Pediatric Intensive Care Unit

Antimicrobial activity of immobilized lactoferrin and lactoferricin

Contact Info

Product

Resources

About