Evaluation of Dexmedetomidine on Hemodynamics in Patients Undergoing Laparoscopic Cholecystectomy

Abstract

BACKGROUND: Dexmedetomidine a newer generation highly selective alpha-2 adrenergic agonist are well known to inhibit catecholamine release. The present study compares the effects of intravenously administered dexmedetomidine to attenuate hemodynamic response to pneumoperitoneum to laparoscopic cholecystectomy under general anaesthesia. METHODOLOGY: 60 patients ASA Physical status I and II, aged between 18 and 50 years of either sex, scheduled for elective laparoscopic cholecystectomy were randomized in to 2 groups (group D and S) inn a double blind fashion to receive either Dexmedetomidine (1microgram/kg) in 100ml of 0.9% normal saline or only 0.9%plain normal saline respectively. It is given 30 min prior to induction. Patient vitals like HR, SBP, DBP, MAP were monitored during the study at various time intervals. RESULTS: Following intubation and pneumoperitoneum there significant rise in HR, MAP, SBP, DBP in group S but no significant rise in Group D. CONCLUSION: Dexmedetomidine given in a dose of 1microgram/kg as a premedication is effective in attenuating the hemodynamic responses in laparoscopic surgery.