Evaluation of different crosslinking methods in altering the properties of extrusion-printed chitosan-based multi-material hydrogel composites

Liu, Suihong; Zhang, Haiguang; Ahlfeld, Tilman; Kilian, David; Liu, Yakui; Gelinsky, Michael; Hu, Qingxi

doi:10.1007/s42242-022-00194-3

Cited by 40 publications

(26 citation statements)

References 54 publications

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“…The rheological properties of different inks were determined as previously reported, [ 49 ] by using a rotational rheometer (DHR‐3, Waters China Limited, USA) with a diameter of 50 mm parallel geometry. Firstly, the gap (1 mm) between two plates were filled by different ink samples (5/0%‐Z, 15/2%‐Z, and 20/4%‐Z) at 30 °C.…”

Section: Methodsmentioning

confidence: 99%

“…The hydrophilicity of nanocomposite GelMA/PVA sample was investigated according to previous method, [ 49 ] by a water contact angle goniometer (OCA15EC, EASTERN‐DATAPHY, China). Each sample was measured using the sessile drop method at room temperature.…”

Section: Methodsmentioning

confidence: 99%

“…Based on previously reported methods, [38,49] a chick embryo angiogenesis (CEA) assay has been employed to evaluate the effect of nanocomposite GelMA/PVA scaffolds on angiogenesis. The fertilized eggs were purchased from the Poultry Institution (Jiangsu, China) and incubated at 37.8 °C with 65% humidity.…”

Section: Chick Embryo Angiogenesis (Cea) Assaymentioning

confidence: 99%

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3D Printing GelMA/PVA Interpenetrating Polymer Networks Scaffolds Mediated with CuO Nanoparticles for Angiogenesis

Liu

et al. 2022

Macromolecular Bioscience

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Biocompatible hydrogels have been considered one of the most well‐known and promising in various materials used in the fabrication of tissue‐engineering scaffolds. Although considerable progress has been made in recent decades, many limitations remain, such as poor mechanical and degradation properties of biomaterials. In addition, vascularization of tissue‐engineering scaffold is an enduring challenge, which limited the fabrication and application of scaffold with clinically relevant dimension. To cover these challenges, in this work, a novel nanocomposite interpenetrating polymer networks (IPN) hydrogel scaffold consists of methacrylated gelatin (GelMA), poly(vinyl alcohol) (PVA), and copper oxide nanoparticles (CuONPs) is fabricated by extrusion‐based 3D printing. A series of physiochemical and biological characterizations of the nanocomposite GelMA/PVA scaffolds are performed. Results showed that the mechanical and degradation properties of the nanocomposite GelMA/PVA scaffolds are obviously improved compared to GelMA scaffolds with single network. In vitro cell experiments and chick embryo angiogenesis (CEA) assay confirmed good cytocompatibility of the fabricated scaffold and its potential to promote cell migration and angiogenesis. In conclusion, altogether the results demonstrated that GelMA/PVA IPN scaffolds modified with CuONPs have great potential for fabrication of volumetric scaffolds and promote angiogenesis during tissue growth and repair.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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3D Printing GelMA/PVA Interpenetrating Polymer Networks Scaffolds Mediated with CuO Nanoparticles for Angiogenesis

Liu

et al. 2022

Macromolecular Bioscience

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“…One of the common methods for controlling the degradation rate is changing the crosslinking degree and the proportion of biomaterial composites. Thus, more research should focus on the mechanism of collagen degradation in vivo at different regeneration stages for tissue engineering applications [ 205 ].…”

Section: Future Perspectivementioning

confidence: 99%

Cutting Edge Aquatic-Based Collagens in Tissue Engineering

Panggabean¹,

Adiguna²,

Hardhiyuna

et al. 2023

Marine Drugs

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Aquatic-based collagens have attracted much interest due to their great potential application for biomedical sectors, including the tissue engineering sector, as a major component of the extracellular matrix in humans. Their physical and biochemical characteristics offer advantages over mammalian-based collagen; for example, they have excellent biocompatibility and biodegradability, are easy to extract, and pose a relatively low immunological risk to mammalian products. The utilization of aquatic-based collagen also has fewer religious restrictions and lower production costs. Aquatic-based collagen also creates high-added value and good environmental sustainability by aquatic waste utilization. Thus, this study aims to overview aquatic collagen’s characteristics, extraction, and fabrication. It also highlights its potential application for tissue engineering and the regeneration of bone, cartilage, dental, skin, and vascular tissue. Moreover, this review highlights the recent research in aquatic collagen, future prospects, and challenges for it as an alternative biomaterial for tissue engineering and regenerative medicines.

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“…The printed filament, as thin as 30 µm, had the capability to guide cellular orientation and provide a suitable environment for cell survival (>90%) and spreading. Liu et al [25] presented a composite hydrogel composed of chitosan/gelatin and egg white, serving as a novel bioink for extrusion-based printing. In addition, from the crosslinking mechanism perspective, tripolyphosphate (TPP) was found to maximally enhance the physical and biological properties of the scaffolds fabricated with the proposed composite hydrogel, showing great potential for future tissue engineering-related applications.…”

mentioning

confidence: 99%

Physics problems in bio or bioinspired additive manufacturing

2023

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Additive manufacturing, also known as three-dimensional (3D) printing, has attracted increasing attention due to the innovations in materials science and manufacturing over recent decades [1]. Recently, innovations in biocompatible materials and biology have enabled the extension of 3D printing techniques into bioadditive manufacturing, which focuses on the fabrication of 3D engineered native-like tissues/organs [2]. Currently, bioadditive manufacturing technologies can be categorized into inkjet-based bioprinting, microextrusion-based bioprinting, digital light processing (DLP) bioprinting, electric field-assisted bioprinting, and fused deposition modeling (FDM), to name a few [3, 4] (Fig. 1). Artificial tissues and organs with delicate structures, such as the heart [5] and liver [6], have been successfully fabricated using various bioadditive manufacturing techniques. Bioadditive manufacturing has also been involved in drug screening due to its high deposition accuracy [7]. However, despite continuous improvements in printing techniques and the broader choice of materials for 3D bioprinting, it remains challenging for 3D bioprinted constructs to be deemed as substitutes for native tissues and organs at the present moment due to their limited printing reliability and functionality [8].

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Evaluation of different crosslinking methods in altering the properties of extrusion-printed chitosan-based multi-material hydrogel composites

Cited by 40 publications

References 54 publications

3D Printing GelMA/PVA Interpenetrating Polymer Networks Scaffolds Mediated with CuO Nanoparticles for Angiogenesis

3D Printing GelMA/PVA Interpenetrating Polymer Networks Scaffolds Mediated with CuO Nanoparticles for Angiogenesis

Cutting Edge Aquatic-Based Collagens in Tissue Engineering

Physics problems in bio or bioinspired additive manufacturing

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