To assess the effects of organic and inorganic N fertilizers regarding wheat yield and growth a field experiment was carried out from November 2019 to March 2020 at the Agronomy Field Laboratory, Bangladesh Agricultural University, Mymensingh. There were three replications of the experiment, which was set up using a randomized full block design. The experiment comprises four varieties viz. BARI Gom-28, BARI Gom-30, BARI Gom-31, BARI Gom-32 and five levels of N viz. Control, 90 kg N ha-1 from prilled urea (PU), 57 kg N ha-1 from prilled urea (PU) + 3 t ha-1 poultry manure (PM) as organic N source, 62 kg N ha-1 from PU + 5 t ha-1 cowdung as organic N source, 29 Kg N ha-1 from PU + 4 t ha-1 vermicompost as organic N source. The outcome of the experiment revealed that there were substantial differences in the growth and yield of wheat due to different varietal effects and application of organic and inorganic nitrogen fertilizers, although some of the attributes were not found significant. At growth, BARI Gom-32 produced the highest number of total tillers hill-1 and leaf area index, while the highest number of total tillers hill-1 and leaf area index were obtained from 57 kg N ha-1 from PU and 3 t ha-1 PM at 20, 40, 60 and 80 DAS. At harvest, the highest number of effective tillers plant-1 (2.82), filled grain spike-1 (32.06), 1000-grain weight (61.07 g), grain yield (3.94 t ha-1), straw yield (5.85 t ha-1) and harvest index (40.11%) were obtained from BARI Gom-32. While, application of 57 kg N ha-1 from PU and 3 t ha-1 PM produced the tallest plant (95.49 cm), number of total tillers plant-1 (3.96), number of effective tillers plant-1 (3.20), filled grain spike-1 (36.61), 1000-grain weight (60.18 g from T5), grain yield (4.34 t ha-1), straw yield (6.23 t ha-1) and harvest index (41.07%). Again, the maximum number of total tillers plant-1 (4.06), number of effective tillers plant-1 (3.46), filled grain spike-1 (39.13), 1000-grain weight (64.62 g), grain yield (4.38 t ha-1), straw yield (6.27 t ha-1 ) and harvest index (41.16%) were found from BARI Gom-32 in combination with 57 kg N ha-1 from prilled urea and 3 t ha-1 poultry manure. Therefore, it can be concluded that BARI Gom-32 in combination with 57 kg N ha-1 from prilled urea and 3 t ha-1 poultry manure was more potential in terms of yield and would be suggested for the cultivation of wheat.