Evaluation of different surgical approaches in the treatment of endometrial cancer at Figo stage I

The role of routine pelvic lymph node sampling in patients with stage I endometrial carcinoma, second thoughts

“…This finding is consistent with the results of a larger and recent study (6) of 425 women with stage I endometrial carcinoma who were divided into three treatment groups: TAHπBSO, TAHπBSOπLNS, and vaginal hysterectomy πBSO. The clinicians concluded that neither the surgical method (abdominal vs vaginal) nor the performance of the LNS procedure conferred any therapeutic benefit.…”

Clinical behavior of 203 stage II endometrial cancer cases: The impact of primary surgical approach and of adjuvant radiation therapy

“…Takeshima et al (28) described pelvic lymph node metastasis in 5% of cases with grade 1 and no myometrial invasion, and these authors therefore stressed that pelvic lymphadenectomy should be performed in all endometrial cancer patients. Based on these considerations, pelvic lymph node dissection would be recommended only for patients with a higher risk of node metastasis (6,(25)(26)(27)(28) . This negligible risk of node metastasis was applicable to approximately 75% of our case population.…”

Clinical value of FDG-PET for preoperative evaluation of endometrial cancer

“…In addition, resection of macroscopic nodal disease is reported to be an important prognostic factor in stage IIIC [12]. On the other hand, the therapeutic value of nodal resection has not been established for patients with stage I or II tumors [13,14], and it has also been reported that patients at lower risk of recurrence could avoid pelvic or paraaortic nodal resection [15,16]. From our results that included some false negative findings, nodal resection should not be omitted on the basis of negative PET findings.…”