As the landscape of education evolves rapidly in the 21st Century, the teachers' instructional practice and ICT technology integration emerge as crucial components in shaping teachers' readiness. Reports from the Basic Education Report (BER) 2023 underscored pervasive issues with technology access, integration, and teacher capacity, readiness in these areas which prompted the researchers to conduct a study to determine the influence level of indicators on future-ready teachers in elementary and secondary education. The study attempted to assess the influence of teachers' instructional practice and ICT technology integration on teachers' readiness in the 21st century with innovative plans for education using quantitative methodologies. A quantitative correlational design was employed with a total number of 200 elementary and secondary public school teachers through universal sampling. It utilized adapted instruments to assess the teachers' readiness in the 21st century. The gathered data was statistically analyzed through SPSS using mean, Pearson r and multiple regression. The study uncovered that the level of teachers' instructional practice, ICT technology integration and teachers' readiness in the 21st Century were very high. A significant relationship existed between teachers' instructional practice, ICT technology integration and teachers' readiness in the 21st century. It was found that the teachers' instructional practice, ICT technology integration positively influenced the teachers' readiness in the 21st century. Recommendations include professional development, teacher readiness assessment, practices for effective teaching and the integrated Project Integrated Learning for Engaging and Real-World Needs (iLearn) to develop teachers' readiness. This research is crucial in equipping teachers to be well-prepared on the demands of teaching skills in the 21st century.