2023
DOI: 10.3390/biomedicines11113090
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Evaluation of Disease Activity in Inflammatory Bowel Disease: Diagnostic Tools in the Assessment of Histological Healing

Alina Ecaterina Jucan,
Otilia Gavrilescu,
Mihaela Dranga
et al.

Abstract: Inflammatory bowel disease (IBD) comprises two types of chronic intestinal disorders: Crohn’s disease and ulcerative colitis. In long-standing ulcerative colitis disease activity, histological persistent inflammation has been linked to an increased risk of relapse, and long-term corticosteroid use, even when endoscopic remission is reached. In Crohn’s disease, the discontinuous nature of lesions and transmural inflammation have limited the standardized histological assessment. The current evidence from researc… Show more

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Cited by 2 publications
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“…Additionally, there was notable heterogeneity in the sensitivity, specificity, and false-positive rates of fecal biomarkers, necessitating further research and validation. In another review, Jucan et al [ 13 ] (Contribution 2) introduced the concept of histological healing (HH) as a therapeutic target in IBD, associated with improved disease prognosis and a decrease in disease-related complications. This study underscores the need for validating and standardizing histological scores to more precisely define micro-activities in clinical practice and trials.…”
Section: An Overview Of the Published Articlesmentioning
confidence: 99%
“…Additionally, there was notable heterogeneity in the sensitivity, specificity, and false-positive rates of fecal biomarkers, necessitating further research and validation. In another review, Jucan et al [ 13 ] (Contribution 2) introduced the concept of histological healing (HH) as a therapeutic target in IBD, associated with improved disease prognosis and a decrease in disease-related complications. This study underscores the need for validating and standardizing histological scores to more precisely define micro-activities in clinical practice and trials.…”
Section: An Overview Of the Published Articlesmentioning
confidence: 99%