Evaluation of Distribution Constants of Lanthanoid(III) Acetylacetonates between Sodium Dodecyl Sulfate Micelles and Water by Micellar Capillary Electrophoresis

Katsuta, Shoichi; Nakatani, Tomohiko

doi:10.1006/jcis.1997.5173

Cited by 6 publications

(2 citation statements)

References 21 publications

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“…Particularly, linear log -log relationships were found between MEKC retention factors of neutral bis-and trisacetylacetonates of various metals [36 -38], as well as cationic lanthanide bis-acetylacetonates [38], and their distribution constants in different organic solventwater systems. MEKC has also been used to evaluate the binding of cationic complexes, e. g., iron(II)(a-diimine) chelates [33 -35], to SDS micelles in terms of the binding constant.…”

Section: Correlation Analysismentioning

confidence: 99%

Application of micellar and microemulsion electrokinetic chromatography for characterization of gallium(III) complexes of pharmaceutical significance

Timerbaev

Vasylenko

Foteeva

et al. 2007

J of Separation Science

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CE with conventional UV detection has recently been shown as a highly effective means to assaying cytotoxic gallium(III)-based compounds with regard to desirable drug-like properties such as the stability and binding to serum proteins. In this extension of that work, different CE techniques are used to further characterize a given set of gallium coordination compounds with established antiproliferating efficacy. Using free-zone CE mode, the electrophoretic profiles of complexes are recorded in order to assess their actual charge state under physiological buffer conditions. Micellar and microemulsion electrokinetic chromatographic techniques are tested as tools for the rapid estimation of the n-octanol-water partition coefficient (log P) that provides a rationale estimate of a drug's ability to cross biological membranes. A range of electrolyte buffer systems with varying (both in the nature and concentration) organic modifiers are examined to evaluate their effect on the relationship between experimental or calculated log P and the retention factors of compounds (log k'). Both methods were found to be better applicable for neutral than for cationic Ga complexes, the microemulsion mode demonstrating superior lipophilicity estimations as well as statistically meaningful log P versus log k' correlations when all the complexes were included in one regression set.

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Section: Correlation Analysismentioning

confidence: 99%

Application of micellar and microemulsion electrokinetic chromatography for characterization of gallium(III) complexes of pharmaceutical significance

Timerbaev

Vasylenko

Foteeva

et al. 2007

J of Separation Science

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“…QSAR models in the earliest reports have basically relied on using partition coefficients (log P) between noctanol (or a different organic solvent) and water [9][10][11]. However, their application is still limited.…”

Section: Introductionmentioning

confidence: 99%

An advanced application of the quantitative structure–activity relationship concept in electrokinetic chromatography of metal complexes

Oszwałdowski

Timerbaev

2008

Electrophoresis

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The relevance of the quantitative structure-activity relationship (QSAR) principle in MEKC and microemulsion EKC (MEEKC) of metal-ligand complexes was evaluated for a better understanding of analyte migration mechanism. A series of gallium chelates were applied as test solutes with available experimental migration data in order to reveal the molecular properties that govern the separation. The QSAR models operating with n-octanol-water partition coefficients or van der Waals volumes were found to be valid for estimation of the retention factors (log k') of neutral compounds when using only an aqueous MEEKC electrolyte. On the other hand, consistent approximations of log k' for both uncharged and charged complexes in either EKC mode (and also with hydro-organic BGEs) were achievable with two-parametric QSARs in which the dipole moment is additionally incorporated as a structural descriptor, reflecting the electrostatic solute-pseudostationary phase interaction. The theoretical analysis of significant molecular parameters in MEKC systems, in which the micellar BGE is modified with an organic solvent, confirmed that concomitant consideration of hydrophobic, electrostatic, and solvation factors is essential for explaining the migration behavior of neutral metal complexes.

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Characterization of iron(II)(α-diimine) chelates and their interactions with anionic, cationic and non-ionic micelles using the separation, spectrophotometric and computational methods

Oszwałdowski

Marchut

2005

Analytica Chimica Acta

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Evaluation of Distribution Constants of Lanthanoid(III) Acetylacetonates between Sodium Dodecyl Sulfate Micelles and Water by Micellar Capillary Electrophoresis

Cited by 6 publications

References 21 publications

Application of micellar and microemulsion electrokinetic chromatography for characterization of gallium(III) complexes of pharmaceutical significance

Application of micellar and microemulsion electrokinetic chromatography for characterization of gallium(III) complexes of pharmaceutical significance

An advanced application of the quantitative structure–activity relationship concept in electrokinetic chromatography of metal complexes

Characterization of iron(II)(α-diimine) chelates and their interactions with anionic, cationic and non-ionic micelles using the separation, spectrophotometric and computational methods

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