Evaluation of DNA cleavage, antimicrobial and anti-tubercular activities of potentially active transition metal complexes derived from 2,6-di(benzofuran-2-carbohydrazono)-4-methylphenol

Kokare, Dhoolesh Gangaram; Kamat, Vinayak; Naik, Krishna; Nevrekar, Anupama; Kotian, Avinash

doi:10.1016/j.molstruc.2016.07.072

Cited by 19 publications

(8 citation statements)

References 33 publications

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“…44 and 43 along with Pd(PPh 3 ) 4 was allowed to react for twenty four hours at 100 °C. The product obtained was a red colored solid (45). To reach the targeted product, 45 was treated with 3-ethylrhodanine (46) and 3 drops of triethylamine was added to this mixture in CHCl 3 in argon environment for 36 hours.…”

Section: Synthetic Strategies Of Benzofuran Derivativesmentioning

confidence: 99%

“…Based on magnetic moment and electronic spectral data, octahedral geometry for the complexes was proposed. [45] Merkushev et al afforded multi-substituted benzofurans via a simple synthesis based on acid-catalyzed domino reaction (Scheme 13). The starting material, salicylic alcohol (82) was prepared by drop wise addition of corresponding solution of salicylaldehyde in dry ether to Grignard reagent in dry ether.…”

Section: Synthetic Strategies Of Benzofuran Derivativesmentioning

confidence: 99%

“…Considering the antibacterial activity against B. subtilis and E. coli, all the complexes exhibited good activity compared to the ligands except nickel. [45] Shankerrao et al, synthesized imidazothiazole derivatives of benzofuran and were tested for antimicrobial activity (Figure 6). compounds 111 b, 111 c and 113 h exhibited good activity against the strains tested.…”

Section: Antibacterial and Antifungal Agentsmentioning

confidence: 99%

“…NMR and mass spectral studies was done to analyze the structure of the synthesized compounds. Based on magnetic moment and electronic spectral data, octahedral geometry for the complexes was proposed [45] …”

Section: Synthetic Strategies Of Benzofuran Derivativesmentioning

confidence: 99%

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Advances in Synthetic Strategies and Medicinal Importance of Benzofurans: A Review

Dwarakanath

Gaonkar

2022

Asian J Org Chem

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Out of the many heterocycles that exhibit pharmaceutical and therapeutic properties, benzofurans remain the most eye-catching to scientists ever since their discovery. From being present in natural products to synthetic analogs they show diverse biological properties which are used to treat various diseases. Interestingly, some of the benzofuran hybrids were docked against COVID-19 Main Protease and it showed appealing results. Apart from medicinal properties it also exhibits some non-drug applications. The structure activity relationship of benzofuran derivatives in many infections draws attention to the extent where drugs can be produced in a short time span which highlights their significance in medicinal chemistry. There are considerable reaction schemes to synthesize this moiety either simple one pot reactions or multistep. Here, we emphasize on the chemistry of benzofurans, synthesis and its derivatives in the recent years, some of which show notable anti-tumor, antifungal, anti-mycobacterial and anti-oxidant activities.

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Section: Synthetic Strategies Of Benzofuran Derivativesmentioning

confidence: 99%

Section: Synthetic Strategies Of Benzofuran Derivativesmentioning

confidence: 99%

Section: Antibacterial and Antifungal Agentsmentioning

confidence: 99%

Section: Synthetic Strategies Of Benzofuran Derivativesmentioning

confidence: 99%

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Advances in Synthetic Strategies and Medicinal Importance of Benzofurans: A Review

Dwarakanath

Gaonkar

2022

Asian J Org Chem

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“…Transition metal complexes are very important compounds in medicinal and pharmaceutical field, they show various biological activities such as anticancer, antitumoral, Antiinflamatory, antimicrobial, antibacterial, antioxidant and anti‐tubercular activities …”

Section: Introductionmentioning

confidence: 99%

DFT Calculations, Spectroscopic Studies, Biological Activity and Non Linear Optical Properties (NLO) of Novel Ternary Cu(II)‐Chelates Derived from 5‐Acetyl‐4‐hydroxy‐2H‐1,3‐thiazinedione

Halim

Adly

2018

Applied Organom Chemis

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New ternary Cu(II)‐chelates with the general formula [ML L′(H2O)x] (NO3)y x (H2O), x = 0–2 and y = 0–1, (L) = 5‐acetyl‐4‐hydroxy‐2H‐1,3‐thiazine‐2,6(3H)‐dione with in the presence of a secondary ligand (L′) [N,O‐donor; 8 hydroxyquinoline or N,N‐donor; 1,10‐phenanthroline and diethethylendiamine]. Characterization of the synthesized complexes was established based on elemental analysis, molar conductance, magnetic susceptibility measurements, spectral (infrared, electronic, mass, 1H‐NMR and ESR) as well as thermal gravimetric analysis (TGA). The complexes exhibited octahedral and square planer geometry. The antimicrobial activity for the studied complexes was tested for different kind of organisms. The geometrical and non‐linear optical parameters of the studied complexes 1–3 are investigated theoretically at the B3LYP/GENECP level of theory. The optimized geometries of the studied complexes are non‐planner as indicated from the dihedral angles. The natural charge population (core, valence and Rydberg), exact electronic configuration, total Lewis, and total non‐Lewis is computed and discussed in terms of natural bond orbitals (NBO) analysis. The calculated EHOMO and ELUMO energies at the same level of theory of the studied complexes were used to calculate the global properties; hardness (η), global softness (S), electrophilicity (ω) and electronegativity (χ). The total dipole moment (μtot), total and anisotropy of polarizability (˂α˃), (Δα) and first hyperpolarizability (˂β˃) values were calculated and compared with urea as a reference compound. From the values of the computed first hyperpolarizability (˂β˃), the ligand and the studied complexes show promising optical properties.

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A Comprehensive Examination of Heterocyclic Scaffold Chemistry for Antitubercular Activity

Bendi,

Yadav,

Saini

et al. 2024

Chemistry & Biodiversity

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Tuberculosis is a communicable disease which affects humans particularly the lungs and is transmitted mainly through air. Despite two decades of intensive research aimed at understanding and combating tuberculosis, persistent biological uncertainties continue to hinder progress. Nowadays, heterocyclic compounds have proven themselves in effective treatment of tuberculosis because of their wide range of biological and pharmacological activities. Antituberculosis or antimycobacterial agents encompass a broad array of compounds utilized singly or in conjunction to combat Mycobacterium infections, spanning from tuberculosis to leprosy. Here, we summarize the synthesis of various heterocyclic compounds which includes the greener synthetic route as well as use of nano compounds as catalyst along with their anti TB activities.

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Evaluation of DNA cleavage, antimicrobial and anti-tubercular activities of potentially active transition metal complexes derived from 2,6-di(benzofuran-2-carbohydrazono)-4-methylphenol

Cited by 19 publications

References 33 publications

Advances in Synthetic Strategies and Medicinal Importance of Benzofurans: A Review

Advances in Synthetic Strategies and Medicinal Importance of Benzofurans: A Review

DFT Calculations, Spectroscopic Studies, Biological Activity and Non Linear Optical Properties (NLO) of Novel Ternary Cu(II)‐Chelates Derived from 5‐Acetyl‐4‐hydroxy‐2H‐1,3‐thiazinedione

A Comprehensive Examination of Heterocyclic Scaffold Chemistry for Antitubercular Activity

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