Evaluation of Dopexamine Hydrochloride as a Renoprotective Agent During Aortic Surgery

Welch, Mark; Newstead, Charles G.; Smyth, J. Vincent; Dodd, P.D.F.; Walker, Michael G.

doi:10.1007/bf02143865

Cited by 22 publications

(7 citation statements)

References 19 publications

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“…Leier reported that dopexamine was the only positive inotrope that significantly increases cardiac output and blood flow in the hepaticsplanchnic bed (13). In major aortic surgery, perioperative infusion of dopexamine resulted in reduced serum creatinine (14). Dopexamine given after induction of anaesthesia was able to prevent renal function abnormalities in patients undergoing orthotopic liver transplantation (15).…”

Section: Discussionmentioning

confidence: 99%

Retracted: Influence of dopexamine hydrochloride on haemodynamics and regulators of circulation in patients undergoing major abdominal surgery

Boldt

Piper

Padberg

et al. 1998

Acta Anaesthesiol Scand

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Section: Discussionmentioning

confidence: 99%

Retracted: Influence of dopexamine hydrochloride on haemodynamics and regulators of circulation in patients undergoing major abdominal surgery

Boldt

Piper

Padberg

et al. 1998

Acta Anaesthesiol Scand

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“…Although Welch and colleagues concluded that dopexamine in patients undergoing aortic artery surgery might offer some renal protection, 100 this has not been confirmed in two other more recent and larger studies. 1 23 Loop diuretics.…”

Section: Drug Therapiesmentioning

confidence: 91%

Kidney dysfunction in the postoperative period

Sear

2005

British Journal of Anaesthesia

255

155

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The development of perioperative acute renal failure is associated with a high incidence of morbidity and mortality. Although this incidence varies with different surgical procedures and with the definition used for renal failure, we now understand better the aetiology of the underlying problem. However, successful strategies to provide renal protection or strategies for 'rescue therapy' are either lacking, unsubstantiated by randomized clinical trials, or show no significant efficacy. The present review considers the physiology and pharmacology of the kidney; the characterization of tests of renal function; the cause of postoperative renal dysfunction; what is presently available for its prevention and treatment; and the effect of postoperative renal impairment on patient outcome.

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“…Drugs such as dopexamine augment cardiac output and may have a role in restoring perfusion, although its renoprotective qualities remain uncertain. 35,36 Low-dose dopamine has no renoprotective effect; data suggest it neither maintains nor improves renal function. 37 Loop diuretics are commonly used in volume control, and have a theoretical benefit of reducing metabolic demand, hence protecting against ischaemic injury.…”

Section: Treatment Modalitiesmentioning

confidence: 99%

Acute Renal Failure and the Critically Ill Surgical Patient

Sykes

Cosgrove

2007

annals

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Acute renal failure can occur following major surgery. Predisposing factors include massive haemorrhage, sepsis, diabetes, hypertension, cardiac disease, peripheral vascular disease, chronic renal impairment and age. Understanding epidemiology, aetiology and pathophysiology can aid effective diagnosis and management. A consensus definition for acute renal failure has recently been developed. It relates to deteriorating urine output, serum creatinine and glomerular filtration rate. In the surgical patient, precipitants are often pre-renal, although intrinsic damage and obstructed urine flow can occur. Worsening renal function results in distal organ damage. Acute renal failure is a marker of disease severity, carrying a poor prognosis if associated with deteriorating respiratory and cardiovascular function. Acute renal failure in the critically ill surgical patient exerts a massive impact on the evolution of complications and prognosis. Management relates to treating life-threatening problems, maintaining effective ventilation and circulation, removal (or reduction) of nephrotoxins and, where appropriate, establishing either renal replacement therapy or palliative care.

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Evaluation of Dopexamine Hydrochloride as a Renoprotective Agent During Aortic Surgery

Cited by 22 publications

References 19 publications

Retracted: Influence of dopexamine hydrochloride on haemodynamics and regulators of circulation in patients undergoing major abdominal surgery

Retracted: Influence of dopexamine hydrochloride on haemodynamics and regulators of circulation in patients undergoing major abdominal surgery

Kidney dysfunction in the postoperative period

Acute Renal Failure and the Critically Ill Surgical Patient

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