Evaluation of doramectin for the treatment of experimental canine spirocercosis

Lavy, Eran; Aroch, Itamar; Bark, Hylton; Markovics, A.; Aizenberg, Itzhak; Mazaki‐Tovi, Michal; Hagag, A.; Harrus, Shimon

doi:10.1016/s0304-4017(02)00250-9

Cited by 51 publications

(44 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Monocytosis was also common, whereas eosinophilia was uncommon (Mazaki-Tovi et al, 2002). There was no correlation between the white cell counts and the existence of any associated inflammatory conditions such as pneumonia or spondylitis and it thus appears that the inflammatory response is as a result of the granuloma itself (MazakiTovi et al, 2002).…”

Section: Clinical Pathologymentioning

confidence: 94%

“…This shortened dosage regimen was believed to result from the combination of two separate pharmacodynamic effects, the prednisolone promoting nodule regression and the ivermectin killing the parasite. However, it is not known if the same would not be true of a shortened dosage regimen in the original study by Lavy et al (2002). It is our experience in South Africa that these smaller, smooth nodules are very responsive to medical treatment with doramectin utilising a variety of regimens, based on clinician preference.…”

Section: Medical Treatmentmentioning

confidence: 96%

“…Mild anaemia is well described and is present in approximately 50% of cases ([MazakiTovi et al, 2002] and [Ranen et al, 2004]). Patients whose nodules have transformed into sarcomas showed an increased incidence of microcytic hypochromic anaemia, which was ascribed to chronic blood loss and melaena due to ulceration of the oesophageal mass (Ranen et al, 2004).…”

Section: Clinical Pathologymentioning

confidence: 99%

“…Doramectin was again shown to be effective by Lavy et al (2002) using an alternative dosing regimen of 400 g/kg, injected SC every 14 days for six treatments, followed by monthly dosing until resolution of the parasitic nodule. Eggs could not be detected in the faeces 3-10 days after the first treatment in four dogs and the second treatment in three dogs.…”

Section: Medical Treatmentmentioning

confidence: 99%

See 3 more Smart Citations

Spirocerca lupi infection in the dog: A review

Merwe

Kirberger

Clift

et al. 2008

The Veterinary Journal

161

191

View full text Add to dashboard Cite

Spirocercosis is a disease occurring predominantly in Canidae, caused by the nematode Spirocerca lupi. Typical clinical signs are regurgitation, vomiting and dyspnoea. The lifecycle involves an intermediate (coprophagous beetle) and a variety of paratenic hosts. Larvae follow a specific migratory route, penetrating the gastric mucosa of the host, migrating along arteries, maturing in the thoracic aorta before eventually moving to the caudal oesophagus. Here the worm lives in nodules and passes larvated eggs which can be detected using zinc sulphate faecal flotation. Histologically, the mature oesophageal nodule is composed mostly of actively dividing fibroblasts.Spirocerca lupi-associated oesophageal sarcomas may occur and damage to the aorta results in aneurysms. A pathognomonic lesion for spirocercosis is spondylitis of the thoracic vertebrae. Primary radiological lesions include an oesophageal mass, usually in the terminal oesophagus, spondylitis, and undulation of the aortic border. Contrast radiography and computed tomography are helpful additional emerging modalities. Oesophageal endoscopy has a greater diagnostic sensitivity than radiography. Endoscopic biopsies are not sensitive for detecting neoplastic transformation. Doramectin is the current drug of choice, effectively killing adult worms and decreasing egg shedding. Early diagnosis of infection is still a challenge and to date no ideal regimen for prophylaxis has been published.

show abstract

Section: Clinical Pathologymentioning

confidence: 94%

Section: Medical Treatmentmentioning

confidence: 96%

Section: Clinical Pathologymentioning

confidence: 99%

Section: Medical Treatmentmentioning

confidence: 99%

See 2 more Smart Citations

Spirocerca lupi infection in the dog: A review

Merwe

Kirberger

Clift

et al. 2008

The Veterinary Journal

161

191

View full text Add to dashboard Cite

show abstract

“…The majority of case reports are from South Africa (Lobetti 2000), Israel (MazakiTovi et al 2002, Aroch et al 2015 and Greece (Mylonakis et al 2001), but the disease has been reported in Hungary (Bokori 1956, Széll et al 2001 as well. The dogs are infected via ingestion of coprophagic beetles, or their avian or small reptile predators.…”

Section: Introductionmentioning

confidence: 99%

Occurrence of Spirocerca lupi Infection in Hungarian Dogs Referred for Gastroscopy

et al. 2017

View full text Add to dashboard Cite

The nematode Spirocerca lupi (Rudolphi 1809) is widely distributed, classically causing parasitic nodules in the esophagus, aortic aneurysms and spondylitis. Clinical signs of infection are regurgitation, vomiting, weight loss, coughing, dyspnea and, rarely, sudden death. This retrospective study (2007 -2016) investigated the prevalence and treatment outcome of Hungarian dogs with esophageal spirocercosis presented at the Endoscope Laboratory of the University of Veterinary Medicine Budapest (ELUVMBP). The change in the annual number of cases/upper gastrointestinal endoscopies (UGIE) and cases/ total number of endoscopies (TNE, the entire case load of ELUVMBP), and the efficacy of different treatment methods were examined. In the time period mentioned above, a total of 30 patients referred for UGIE were diagnosed with spirocercosis. The annual case numbers significantly increased in comparison to both the number of UGIEs (P = 0.0085) and TNEs (P = 0.0096). The annual distribution of cases does not differ significantly from an even distribution (P = 0.1589). Our study showed a significant increase in the number Original Article S100 EndoparasitEs of cases with spiro cercosis in Hungary between 2007 and 2016, and this this disease is prevalent at all times of year.

show abstract

Parasites of Dogs

Bowman

Baker

2007

Flynn's Parasites of Laboratory Animals

View full text Add to dashboard Cite

Evaluation of doramectin for the treatment of experimental canine spirocercosis

Cited by 51 publications

References 10 publications

Spirocerca lupi infection in the dog: A review

Spirocerca lupi infection in the dog: A review

Occurrence of Spirocerca lupi Infection in Hungarian Dogs Referred for Gastroscopy

Parasites of Dogs

Contact Info

Product

Resources

About