“…New genetic techniques may allow us the opportunity to begin -not to bypass -this "lengthy and tedious" (Wolter et al, 2019) work. Whereas earlier researchers emphasized the ways that humans had discovered loss-of-function plant mutations during domestication, leaving plants dependent upon farmers for their defense and dispersal (Zohary and Hopf, 2000;Anderson, 2005), the emerging consensus is that domestication is a long-term, co-evolutionary deepening of a mutualistic relationship, involving cultural, technological, biological, and ecological factors (Zeder et al, 2006;Gepts, 2010;Meyer et al, 2012;Meyer and Purugganan, 2013;Gremillion et al, 2014;Larson et al, 2014;Allaby et al, 2017;Swanson et al, 2018; and see especially the review by Zeder, 2015). Historically, the genetic changes that have come to distinguish domesticated plants from their wild relatives are the outcome of an interaction of sociocultural and environmental pressures reflecting broader changes in human preference and agronomic intervention.…”