Evaluation of Drug Contamination Levels in an Admixture Preparation Area

Christenson, I; Jansson, Bo

doi:10.1111/j.1365-2710.1983.tb01102.x

Cited by 1 publication

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Withdrawing the needle from an overpressurized vial was found to produce the largest spots. In our study, the use of air vent needles to equilibrate pressure was recognized to minimize the leakage and aerosolization risks while withdrawing drugs from vials (Christienson and Jansson, 1983). Despite the use of air vent needles, spillage may occur during transfer operations (removal of liquid from vials or injection into infusion bags).…”

Section: Discussionmentioning

confidence: 99%

Environmental Contamination with Cytotoxic Drugs in Healthcare Using Positive Air Pressure Isolators

Crauste–Manciet

Sessink²,

Ferrari³

et al. 2005

The Annals of Occupational Hygiene

View full text Add to dashboard Cite

Occupational exposure to cytotoxic drugs of hospital personnel involved in their preparation and administration is a major issue: ever since the introduction of protective measures in recent decades, the handling of these drugs has always been referred to as an occupational health hazard. Isolator technology was one of the protective equipments aimed at providing safe handling, but it has not yet been studied regarding contamination. The present study evaluates surface contamination with four cytotoxic drugs [cyclophosphamide (CP), ifosfamide (IF), 5 fluorouracil (5FU) and methotrexate (MTX)] by wipe sampling in two hospital pharmacies. Wipe samples were taken from work surfaces both located inside and outside the isolators. In addition, working gloves, the surface of infusion bags filled with 5FU or CP, and gloves used in simulation of drug administration were analyzed. Contamination was routinely found inside the isolators but rarely outside the isolators, indicating that the isolator technology is offering good protection of the cytotoxic drug handlers as well as the environment during preparation. On the other hand, contamination was found on the surfaces of infusion bags and gloves in contact with infusion bags filled with cytotoxic drugs. Consequently, personal protective equipment is still recommended during the manipulation and administration of the drugs because of potentially contaminated drug vials and final products.

show abstract

Section: Discussionmentioning

confidence: 99%