A physical-based model for the flow stress of bcc metals is presented. Here, thermally activated and viscous drag regimes are considered. For the thermally activated component of the flow stress, the diffusion-controlled regime at elevated temperature is also taken into account assuming the non-linear dependence of the activation volume on temperature. The model was applied to A508 (16MND5) steel showing the possibility to accurately describe the variation of the flow stress over the entire temperature range (from 0 K to Tm) and over a wide strain-rate range.