Evaluation of early liver graft performance by the indocyanine green plasma disappearance rate

Stockmann, Martin; Lock, Johan Friso; Malinowski, Maciej

doi:10.1002/lt.22068

Cited by 7 publications

(1 citation statement)

References 8 publications

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“…A quantitative, personalized determination of a specific metabolic process, for example determination of the metabolic capacity of the liver, will provide key information to physicians to optimize therapy and surgery [17][18][19][20]. Yet most breath tests are only able to deliver information for groups of patients and not for a single patient.…”

Section: Introductionmentioning

confidence: 99%

Quantitative determination of metabolization dynamics by a real-time ¹³ CO ₂ breath test

Rubin¹,

Haimberger²,

Helmke³

et al. 2011

J. Breath Res.

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We have developed a flow-through fast liver investigation packet (FLIP) to quantitatively measure the amount of exhaled (13)CO(2), as a result of liver metabolization processes. The FLIP system allows investigation of every single breath in real time. Line width variations due to interactions with other gas components disturb traditional measurements and limit their sensitivity to the ppm range. Detection of the complete breath volume and the spectrally fully resolved line shape allows sensitivity in the ppb range with a standard deviation of approximately 80 ppb, a prerequisite to quantitatively analyze liver metabolization processes.

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Section: Introductionmentioning

confidence: 99%

Quantitative determination of metabolization dynamics by a real-time ¹³ CO ₂ breath test

Rubin¹,

Haimberger²,

Helmke³

et al. 2011

J. Breath Res.

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Low serum factor V level: early predictor of allograft failure and death following liver transplantation

Zulian

Chedid

et al. 2015

Langenbecks Arch Surg

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Intraoperative ICG plasma disappearance rate helps to predict absence of early postoperative complications after orthotopic liver transplantation

Vos

Scheeren

Lukes

et al. 2013

J Clin Monit Comput

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Early postoperative complications after orthotopic liver transplantation (OLT) are a common problem in intensive care medicine. Adequate assessment of initial graft function remains difficult, however, plasma disaperance rate of indocyanine green (PDRICG) may have an additional diagnostic and prognostic value in this setting. We retrospectively evaluated the ability of intraoperative PDRICG values to predict absence of early postoperative complications in 62 subjects. PDRICG was measured non-invasively by pulse dye densitometry during surgery and was correlated with initial graft function. At the end of surgery, PDRICG was higher in patients without complications: 24.9 % min(-1) (n = 40) versus 21.0 % min(-1), (n = 22; p = 0.034). An area under the ROC curve (AUROC) for PDRICG was 0.70, while the AUROC for pH, lactate and PT at ICU admission were 0.53, 0.50 and 0.46, respectively. The AUROC of serum bilirubin and PT at postoperative day 5 were 0.68 and 0.49, respectively. The optimal cut-off PDRICG value for predicting absence of development early postoperative complications was determined to be 23.5 % min(-1) with 72.4 % sensitivity and 71.0 % specificity. Intraoperative point-of-care PDRICG measurement during OLT already predicts absence of early postoperative complications, better and earlier than clinically used laboratory parameters.

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Evaluation of early liver graft performance by the indocyanine green plasma disappearance rate

Cited by 7 publications

References 8 publications

Quantitative determination of metabolization dynamics by a real-time ¹³ CO ₂ breath test

Quantitative determination of metabolization dynamics by a real-time ¹³ CO ₂ breath test

Low serum factor V level: early predictor of allograft failure and death following liver transplantation

Intraoperative ICG plasma disappearance rate helps to predict absence of early postoperative complications after orthotopic liver transplantation

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Evaluation of early liver graft performance by the indocyanine green plasma disappearance rate

Cited by 7 publications

References 8 publications

Quantitative determination of metabolization dynamics by a real-time 13 CO 2 breath test

Quantitative determination of metabolization dynamics by a real-time 13 CO 2 breath test

Low serum factor V level: early predictor of allograft failure and death following liver transplantation

Intraoperative ICG plasma disappearance rate helps to predict absence of early postoperative complications after orthotopic liver transplantation

Contact Info

Product

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Quantitative determination of metabolization dynamics by a real-time ¹³ CO ₂ breath test

Quantitative determination of metabolization dynamics by a real-time ¹³ CO ₂ breath test