Evaluation of Early Nerve Regeneration Using a Polymeric Membrane Functionalized With Nerve Growth Factor (NGF) After a Crush Lesion of the Rat Mental Nerve

Savignat, Mathilde; Vodouhe, C.; Ackermann, Alain; Haïkel, Youssef; Lavalle, Philippe; Libersa, Philippe

doi:10.1016/j.joms.2007.06.654

Cited by 19 publications

(15 citation statements)

References 41 publications

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“…the direct assessment, the NGF group at 6 weeks showed meaningfully higher CV (2.675 m/second) and PV (1.940 mV) than the PBS group at 6 weeks (1.892 m/second and 1.300 mV, respectively). This finding was consistent with a study by Savignat et al 40,41 who used an NGF-coated polymeric membrane in crush injuries of the rat mental nerve. The activation potential at 1 month after surgery increased considerably in the NGF group, whereas it decreased considerably in the control group.…”

Section: Discussionsupporting

confidence: 93%

Simultaneous Inferior Alveolar Nerve Regeneration and Osseointegration With a Nerve Growth Factor-Supplying Implant: A Preliminary Study

Lee

Jahng

Kim

et al. 2015

Journal of Oral and Maxillofacial Surgery

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Section: Discussionsupporting

confidence: 93%

Simultaneous Inferior Alveolar Nerve Regeneration and Osseointegration With a Nerve Growth Factor-Supplying Implant: A Preliminary Study

Lee

Jahng

Kim

et al. 2015

Journal of Oral and Maxillofacial Surgery

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“…[ 38,[71][72][73] In incorporating NGFs to these different supports, the number of mature nerve fi bers increases resulting in better functional recovery, including the speed of nerve conduction, compared to control groups where NGF is absent. In the presence of NGFs, the diameters of the axons found in the functionalized conduits were larger than the nerve conduits not containing NGFs.…”

Section: Nerve Growth Factormentioning

confidence: 99%

Recent Strategies in Tissue Engineering for Guided Peripheral Nerve Regeneration

Belanger

Dinis

Sami

et al. 2016

Macromolecular Bioscience

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The repair of large crushed or sectioned segments of peripheral nerves remains a challenge in regenerative medicine due to the complexity of the biological environment and the lack of proper biomaterials and architecture to foster reconstruction. Traditionally such reconstruction is only achieved by using fresh human tissue as a surrogate for the absence of the nerve. However, recent focus in the field has been on new polymer structures and specific biofunctionalization to achieve the goal of peripheral nerve regeneration by developing artificial nerve prostheses. This review presents various tested approaches as well their effectiveness for nerve regrowth and functional recovery.

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“…Nowadays, there are many molecular biological and tissue engineering approaches such as stem cell or cytokine 4,7) . Studies related to IAN have been consistently carried out as well 1,8,9) ; in most cases, they were related to the nerve graft through microsurgery and nerve regeneration using histologic carrier, focusing on function recovery. According to Gregg 1) , the symptoms may be improved for patients with damaged IAN by surgically decompressing nerve tissue through a surgical method.…”

Section: Introductionmentioning

confidence: 99%

Animal Model for the Evaluation of Repair of Injured Inferior Alveolar Nerve with Nerve Growth Factor

Lee¹,

Park²,

Heo³

et al. 2013

Journal of Korean Dental Science

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The inferior alveolar nerve (IAN) can be damaged as a result of minor oral surgical procedure such as third molar extraction or implant placement. Repair of the injured IAN involves difficulty of access, and research studies are limited to elucidating the process of regeneration by surgical methods. This study sought to establish the rabbit animal model to apply polymeric membrane functionalized with nerve growth factor after a crush lesion for the evaluation of nerve regeneration using the electrophysiologic method. Materials and Methods: The IAN of 2 adult male New Zealand white rabbits (4 nerves) were exposed bilaterally, and crush injury rendered by jeweler's forceps was applied. Nerve conduction velocity was examined electrophysiologically using electromyography before, after, and 4 weeks after the crush injury. To evaluate the regeneration, the pattern of action potential of IAN was recorded, and the characteristics of neurons were histologically observed. Result: After the crush injury, afferent activity decreased in the injured group. Electromyography could not be recorded after four weeks because tissues surrounding the injured nerve collapsed. Decrease in the mean number of axons was observed in the injured part with membrane. Conclusion: Despite the limited result, the present animal model study may provide a possible way to research on the methods of enhancing the recovery of nerve injuries in clinical situations. For clinically widespread acceptance, however, it should gain more consecutive and scientific evidences.

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Evaluation of Early Nerve Regeneration Using a Polymeric Membrane Functionalized With Nerve Growth Factor (NGF) After a Crush Lesion of the Rat Mental Nerve

Cited by 19 publications

References 41 publications

Simultaneous Inferior Alveolar Nerve Regeneration and Osseointegration With a Nerve Growth Factor-Supplying Implant: A Preliminary Study

Simultaneous Inferior Alveolar Nerve Regeneration and Osseointegration With a Nerve Growth Factor-Supplying Implant: A Preliminary Study

Recent Strategies in Tissue Engineering for Guided Peripheral Nerve Regeneration

Animal Model for the Evaluation of Repair of Injured Inferior Alveolar Nerve with Nerve Growth Factor

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