Evaluation of early retinal vascular changes by optical coherence tomography angiography in children with type 1 diabetes mellitus without diabetic retinopathy

Koca, Serkan Bilge; Joshi, Mohan P; Koca, Semra

doi:10.1007/s10792-021-02059-7

Cited by 5 publications

(6 citation statements)

References 41 publications

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“…Among the remaining 38 studies, we found that 10 were inconsistent with our study objectives, 4 had unconditional interventions, and 6 needed to meet the inclusion criteria after reading the full text. Therefore, 18 articles were eventually included in our meta‐analysis 12,18,21–35 . The detailed screening process is shown in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…37,38 It can display the vascular images of the retina and choroid in layers, distinguish the superficial and deep vascular plexus, and show vascular perfusion in detail through qualitative and quantitative reports. 16,25,39 Some studies 12,18,21,24,27,30,31,33,34 demonstrated that diabetic patients without retinopathy had lower superficial and deep retinal vessel density in the paramacular zone compared with healthy individuals, suggesting that OCTA may play an essential role in detecting the early changes of DR. However, some studies 22,25,28,[40][41][42] did not find the value changes.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, 18 articles were eventually included in our meta-analysis. 12,18,[21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] The detailed screening process is shown in…”

Section: Study Selectionmentioning

confidence: 99%

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Optical coherence tomography angiography for detection of microvascular changes in early diabetes: A systematic review and meta‐analysis

Yang,

Zou,

et al. 2024

Diabetes Metabolism Res

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AimsTo evaluate the effectiveness of optical coherence tomography angiography (OCTA) in detecting early intraocular microvascular changes in diabetic patients.Materials and MethodsA systematic study search was performed on PubMed, Medline, Embase, and the Cochrane Library, ranging from January 2012 to March 2023. Controlled studies compared diabetes mellitus (DM) patients with non‐diabetic retinopathy (NDR) or patients with mild non‐proliferative diabetic retinopathy (mild NPDR) to healthy people. These studies included parameters of OCTA such as foveal avascular zone (FAZ), vessel density of superficial capillary plexus (VDscp), vessel density of deep capillary plexus (VDdcp), and peripapillary VD. The relevant effect model was used according to the heterogeneity, and the mean difference and 95% confidence intervals were calculated.ResultsA total of 18 studies with 2101 eyes were eventually included in this meta‐analysis. Our results demonstrated that early alterations of VDscp, VDdcp, and peripapillary VD in NDR patients had a significant difference compared with healthy people by OCTA (VDscp: WMD = −1.34, 95% CI: −1.99 to −0.68, P < 0.0001. VDdcp: WMD = −2.00, 95% CI: −2.95 to −1.04, P < 0.0001. Peripapillary VD: WMD = −1.07, 95% CI: −1.70 to −0.43, P = 0.0010). However, there was no statistically significant difference in total FAZ between them (WMD = −0.00, 95% CI: −0.02–0.01, P = 0.84). In addition, for patients with mild NPDR, OCTA could illustrate prominent changes in VDscp, VDdcp, and total FAZ compared with healthy people (VDscp: WMD = −6.11, 95% CI: −9.90 to −2.32, P = 0.002. VDdcp: WMD = −4.26, 95% CI: −5.95 to −2.57, P < 0.00001. FAZ: WMD = 0.06, 95% CI: 0.01–0.11, P = 0.03).ConclusionsIn diabetic patients with or without retinopathy, the parameters of OCTA such as VDscp, VDdcp, and peripapillary vessel density were demonstrated as potential biomarkers in monitoring the early alterations of retinal microangiopathy, while total FAZ may have no significant changes in diabetic patients without retinopathy.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Optical coherence tomography angiography for detection of microvascular changes in early diabetes: A systematic review and meta‐analysis

Yang,

Zou,

et al. 2024

Diabetes Metabolism Res

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“…Even before clinical findings and retinopathy develop, OCT-A can be used for the evaluation of retinal microvasculature and as a screening imaging technique to detect early vascular changes as well as disease progression in children with inflammatory diseases with eye involvement. [14][15][16][17][18] Retinal and choroidal involvement have been documented in COVID-19 pediatric patients but there is not enough information about MIS-C in the literature. This study investigated vascular and perfusional changes in the retina and choroid of children with MIS-C using the OCT-A device.…”

Section: O R I G I N a L A R T I C L E Evaluation Of Vascular And Per...mentioning

confidence: 99%

“…In recent years, numerous studies demonstrated that OCT‐A has a key place in assessing early microvascular changes in children with eye problems due to inflammatory diseases such as Type 1 DM, Vogt–Koyanagi–Harada disease, glaucoma, uveitis, multiple sclerosis, and chronic renal diseases. Even before clinical findings and retinopathy develop, OCT‐A can be used for the evaluation of retinal microvasculature and as a screening imaging technique to detect early vascular changes as well as disease progression in children with inflammatory diseases with eye involvement 14–18 …”

Section: Introductionmentioning

confidence: 99%

Evaluation of vascular and perfusional changes in the retina and choroid of children with multisystem inflammatory syndrome

Hızlı

Dereci

Özdemir³

et al. 2023

Pediatrics International

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BackgroundMultisystem inflammatory syndrome in children (MIS‐C) is hyperinflammation following coronavirus disease 2019 (COVID‐19), which affects many organs. The retina and choroid are affected by COVID‐19 through microangiopathy and thrombosis but the literature on MISC‐C is limited.MethodsThirty children (60 eyes) with MIS‐C (the study group, or SG) and 32 age‐and gender‐matched healthy children (64 eyes) (the control group, or CG) were included in the prospective case–control study. Complete ophthalmological examinations, measurements of the vessel densities of the retinal layers, and flow area of the outer retina and choriocapillaris in both groups were conducted with optical coherence tomography angiography (OCT‐A).ResultsThe mean age of the SG was 11.9 ± 3.9 and that of the CG was 12.5 ± 4.6 years (p = 0.197). In this study we found that the vessel density of the deep layer of the inner retina was decreased significantly and was reduced in the outer retina of flow area in the SG in comparison with the CG (p < 0.05, for all). However, there was no significant difference between the groups regarding other measurements.ConclusionsIn MIS‐C patients, vessel densities in the deep layer of the inner retina and in the flow area of the outer retina decreased significantly. This OCTA‐A finding suggests that MIS‐C is related to endothelial thrombotic condition problems in small branches of the retinal artery. The results of this study support the idea that there is a need for screening of MIS‐C patients for the presence of these microangiopathic and perfusional complications.

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Structural and functional characterization of retinal impairment in T1DM patients without diabetic retinopathy: a 3-year longitudinal study

Sacconi,

Tombolini,

Cartabellotta

et al. 2024

Acta Diabetol

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Evaluation of early retinal vascular changes by optical coherence tomography angiography in children with type 1 diabetes mellitus without diabetic retinopathy

Cited by 5 publications

References 41 publications

Optical coherence tomography angiography for detection of microvascular changes in early diabetes: A systematic review and meta‐analysis

Optical coherence tomography angiography for detection of microvascular changes in early diabetes: A systematic review and meta‐analysis

Evaluation of vascular and perfusional changes in the retina and choroid of children with multisystem inflammatory syndrome

Structural and functional characterization of retinal impairment in T1DM patients without diabetic retinopathy: a 3-year longitudinal study

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