Evaluation of Effect CAT -262C/T, SOD + 35A/C, GPx1 Pro197Leu Polymorphisms in Patients with IBD in the Polish Population

Mrowicki, Jerzy; Mrowicka, Małgorzata; Majsterek, Ireneusz; Mik, Michał; Dziki, Adam; Dziki, Łukasz

doi:10.1515/pjs-2016-0071

Cited by 9 publications

(8 citation statements)

References 6 publications

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“…In the UC patients was not found statistical relationship with IBD but the observed protective tendency. These findings confirmed earlier our observations: trend protective, but statistically unrelated, it was observed for genotype T/T and T allele of the + 35A/C SOD1 polymorphism in UC [ 3 ].…”

Section: Discussionsupporting

confidence: 93%

“…In a previous study we had demonstrated on a smaller number of patients that the polymorphism of antioxidant enzymes CAT gene C-262T may have protective effects in UC patients carrying the C/T variant [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…In our pilot analysis we had demonstrated that polymorphic variant of the CAT -262 C/T may have protective effects in patients with UC [ 3 ]. Since the previous analysis of the patients in the group of half the smaller numbers did not make any clear conclusions, we decided to continue working and increase the number of IBD patients as well as the control group.…”

Section: Introductionmentioning

confidence: 99%

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Association between SOD1, CAT, GSHPX1 polymorphisms and the risk of inflammatory bowel disease in the Polish population

et al. 2017

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PurposeThe main aim of this study was investigate the association between the genetic polymorphism of antioxidant enzyme genes: SOD1, CAT and GSHPX1 and the risk of inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis in the Polish population.MethodsA total of 445 subjects including 200 patients with IBD and 245 controls were allowed in this study. We determined activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx1) and examination their association with the SNPs of respective genes (SOD1 +35A/C, CAT C-262T and GSHPX1 Pro197Leu). RFLP technique was used to determine the selected genes polymorphisms. Antioxidant enzymes activity were evaluated in erythrocyte hemolysate of 23 patients with non-active IBD and 30 healthy participants.ResultsThe A/C genotype and the C allele frequencies of A/C polymorphism of SOD1 gene were significantly associated with the reduced risk of IBD (OR=0.43; 95% CI 0.23; 0.83). Alike, C/T (OR=0.45; 95% CI= 0.29; 0.70) and T/T genotype (OR=0.43; 95% CI= 0.21; 0.87) of GSHPX1 gene polymorphism diminished the susceptibility to IBD. A significant decrease of CAT (P=0.028) and increase of GPx1 (P=0.025) enzyme activities were seen in IBD patients compared to control.ConclusionsOur data confirm dysregulated antioxidant capacity in patients suffering from IBD. Both, the SOD1 A/C genotype as well as GSHPX1 C/T and T/T genotypes may be associated with a reduction risk of IBD in the Polish population.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between SOD1, CAT, GSHPX1 polymorphisms and the risk of inflammatory bowel disease in the Polish population

et al. 2017

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“…Polymorphism of catalase gene in the promoter region (rs1001179) affects transcription factor binding and thus decreases enzymatic activity of catalase leading to increased formation of hydroxyl radicals and elevated risk of asbestosis, breast cancer development, and arsenic-induced hyperkeratosis. 42 Recently, the association between the polymorphisms of CAT gene with glaucoma, 43 ulcerative colitis, 44 diabetes, 45 hypertension, 46 and Alzheimer's disease 47 have been investigated.…”

Section: Discussionmentioning

confidence: 99%

No evidence for a major effect of three common polymorphisms of the GPx1, MnSOD, and CAT genes on PCOS susceptibility

Salahshoor

Sohrabi

Jalili

et al. 2018

J of Cellular Biochemistry

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“…In recent years, the genetic variations of several antioxidant enzyme genes have been associated with IBD. Some examples include the genes encoding superoxide dismutase 2, glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, paraoxonase 1, and nuclear factor- (erythroid-derived 2) like 2 [ 54 – 61 ]. Interestingly, the loss of peroxiredoxin 6, an important antioxidative protein, partially protected mice against both acute and chronic DSS-induced colitis, likely by promoting a compensatory elevation of other antioxidative enzymes in the gastrointestinal tract [ 62 ].…”

Section: Cellular Stress Signaling In Gastrointestinal Tractmentioning

confidence: 99%

Cellular Stress Responses and Gut Microbiota in Inflammatory Bowel Disease

Cao

2018

Gastroenterology Research and Practice

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Progresses in the past two decades have greatly expanded our understanding of inflammatory bowel disease (IBD), an incurable disease with multifaceted and challenging clinical manifestations. The pathogenesis of IBD involves multiple processes on the cellular level, which include the stress response signaling such as endoplasmic reticulum (ER) stress, oxidative stress, and hypoxia. Under physiological conditions, the stress responses play key roles in cell survival, mucosal barrier integrity, and immunomodulation. However, they can also cause energy depletion, trigger cell death and tissue injury, promote inflammatory response, and drive the progression of clinical disease. In recent years, gut microflora has emerged as an essential pathogenic factor and therapeutic target for IBD. Altered compositional and metabolic profiles of gut microbiota, termed dysbiosis, are associated with IBD. Recent studies, although limited, have shed light on how ER stress, oxidative stress, and hypoxic stress interact with gut microorganisms, a potential source of stress in the microenvironment of gastrointestinal tract. Our knowledge of cellular stress responses in intestinal homeostasis as well as their cross-talks with gut microbiome will further our understanding of the pathogenesis of inflammatory bowel disease and probably open avenues for new therapies.

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Evaluation of Effect CAT -262C/T, SOD + 35A/C, GPx1 Pro197Leu Polymorphisms in Patients with IBD in the Polish Population

Cited by 9 publications

References 6 publications

Association between SOD1, CAT, GSHPX1 polymorphisms and the risk of inflammatory bowel disease in the Polish population

Association between SOD1, CAT, GSHPX1 polymorphisms and the risk of inflammatory bowel disease in the Polish population

No evidence for a major effect of three common polymorphisms of the GPx1, MnSOD, and CAT genes on PCOS susceptibility

Cellular Stress Responses and Gut Microbiota in Inflammatory Bowel Disease

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