Evaluation of Effect of Melatonin on Hematological Parameters in Patients of Periodontitis

Marawar, Anagha; Marawar, P. P.; Nandal, Dattatray H.; Kunkulol, Rahul; Narwane, Sandeep

doi:10.31878/ijcbr.2019.52.10

Cited by 2 publications

(16 citation statements)

References 8 publications

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“…Of the included studies, 4 were from Spain, 3 were from India, 3 were from Iran, and 1 each from Italy and Egypt. Six studies were clinical interventions without randomization, two were clinical interventional studies [ 6 , 25 ], two were clinical trials [ 8 , 26 ], and two were prospective longitudinal studies [ 30 , 32 ]. The other six studies were RCTs.…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies [ 7 , 28 , 29 , 30 , 31 , 32 , 33 , 42 ] used melatonin for oral consumption. The details of the studies included are presented in Table 3 .…”

Section: Resultsmentioning

confidence: 99%

“…The details of the studies included are presented in Table 3 . Of these, one study used 1 mg melatonin [ 31 ], one study prescribed 2 mg melatonin [ 28 ], three studies used 3 mg melatonin [ 30 , 32 , 42 ], two studies used 6 mg melatonin [ 7 , 33 ], and one study prescribed 10 mg melatonin [ 29 ]. All studies advocated melatonin at night and subjected patients to SRP.…”

Section: Resultsmentioning

confidence: 99%

“…One study recommended the use of chlorhexidine mouthwash (0.12%) [ 29 ], while another study recommended the use of chlorhexidine mouthwash (0.2%) until study completion [ 31 ]. Concerning the period of melatonin consumption, four studies prescribed melatonin for 4 weeks [ 28 , 30 , 32 , 42 ], two studies recommended the same for 8 weeks [ 7 , 33 ], one study advised the intake for 2 months [ 29 ], and the other recommended use for 1 month [ 31 ]. The follow-up appointments were heterogeneous.…”

Section: Resultsmentioning

confidence: 99%

“…In this regard, some in vitro studies [ 22 ] and animal studies [ 23 , 24 ] have been performed and have demonstrated the beneficial effects of melatonin. In human studies, melatonin has been used either in the topical formulation (TF) or systemic formulation (SF) as a monotherapy or adjunctive therapy following SRP [ 6 , 7 , 8 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. However, no systematic review and meta-analysis has critically appraised the use of melatonin in periodontitis.…”

Section: Introductionmentioning

confidence: 99%

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Melatonin as a Topical/Systemic Formulation for the Management of Periodontitis: A Systematic Review

Balaji¹,

Varadarajan

Jagannathan

et al. 2021

Materials

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Objectives: To qualitatively and quantitatively review the use of melatonin as a topical/systemic formulation for the management of periodontitis. Materials and methods: PubMed; Scopus; and Web of Science databases were searched using the MesH terms “melatonin” and “periodontitis”. Title and abstracts were screened to eliminate irrelevant and duplicate articles. The full text data of the screened articles were assessed using the selection criteria. Results: Of 176 identified articles (PubMed-66; Scopus-56; Web of Science-52; Cross-reference-2), only 12 studies qualified to be included in the systematic review. Four studies assessed the independent effect of 1% topical melatonin formulation while 8 articles assessed the adjunctive use of systemic melatonin formulation (1–10 mg) following scaling and root planing (SRP). All studies showed an improvement in periodontal parameters such as pocket depth, clinical attachment loss, periodontal disease index, community periodontal index, gingival bleeding scores, and prognostic marker levels in saliva and serum. A meta-analysis of data from 2 studies revealed that 1–2 mg (systemic) melatonin supplementation reduced pocket depth; although the difference was not statistically significant and hence cannot be interpreted or used for conclusive evidence. Risk of Bias Assessment tool (RoBANS) and Cochrane Collaboration RoB tool elicited a high risk of bias in the included studies. GRADE (recommendation assessment, development, and evaluation) inferred a weak recommendation for the use of melatonin in periodontitis management. Conclusions: Melatonin supplementation (topical and systemic) in periodontitis patients improved key periodontal parameters including pocket depth and clinical attachment loss. Clinical relevance: Melatonin could be a potential host modulatory agent for periodontitis management; although the data from the present review should be interpreted carefully due to the associated high risk of bias.

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Section: Resultsmentioning

confidence: 99%

“…Eight studies [ 7 , 28 , 29 , 30 , 31 , 32 , 33 , 42 ] used melatonin for oral consumption. The details of the studies included are presented in Table 3 .…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Melatonin as a Topical/Systemic Formulation for the Management of Periodontitis: A Systematic Review

Balaji¹,

Varadarajan

Jagannathan

et al. 2021

Materials

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Considerations on the Controlled Delivery of Bioactive Compounds through Hyaluronic Acid Membrane

et al. 2022

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(1) Background: The standard treatment for periodontal disease, a chronic inflammatory state caused by the interaction between biofilms generated by organized oral bacteria and the local host defense response, consists of calculus and biofilm removal through mechanical debridement, associated with antimicrobial therapy that could be delivered either systemically or locally. The present study aimed to determine the effectiveness of a hyaluronic acid membrane matrix as a carrier for the controlled release of the active compounds of a formulation proposed as a topical treatment for periodontal disease, and the influence of pH on the complex system’s stability. (2) Methods: The obtained hyaluronic acid (HA) hydrogel membrane with dispersed melatonin (MEL), metronidazole (MZ), and tetracycline (T) was completely characterized through FTIR, XRD, thermal analysis, UV-Vis and fluorescence spectroscopy, fluorescence microscopy, zeta potential and dielectric analysis. The MTT viability test was applied to check the cytotoxicity of the obtained membranes, while the microbiological assessment was performed against strains of Staphylococcus spp. and Streptococcus spp. The spectrophotometric investigations allowed to follow up the release profile from the HA matrix for MEL, MZ, and T present in the topical treatment considered. We studied the behavior of the active compounds against the pH of the generated environment, and the release profile of the bioactive formulation based on the specific comportment towards pH variation. The controlled delivery of the bioactive compounds using HA as a supportive matrix was modeled applying Korsmeyer–Peppas, Higuchi, first-order kinetic models, and a newly proposed pseudo-first-order kinetic model. (3) Results: It was observed that MZ and T were released at higher active concentrations than MEL when the pH was increased from 6.75, specific for patients with periodontitis, to a pH of 7.10, characterizing the healthy patients. Additionally, it was shown that for MZ, there is a burst delivery up to 2.40 × 10−5 mol/L followed by a release decrease, while for MEL and T a short release plateau was recorded up to a concentration of 1.80 × 10−5 mol/L for MEL and 0.90 × 10−5 mol/L for T, followed by a continuous release; (4) Conclusions: The results are encouraging for the usage of the HA membrane matrix as releasing vehicle for the active components of the proposed topical treatment at a physiological pH.

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Evaluation of Effect of Melatonin on Hematological Parameters in Patients of Periodontitis

Cited by 2 publications

References 8 publications

Melatonin as a Topical/Systemic Formulation for the Management of Periodontitis: A Systematic Review

Melatonin as a Topical/Systemic Formulation for the Management of Periodontitis: A Systematic Review

Considerations on the Controlled Delivery of Bioactive Compounds through Hyaluronic Acid Membrane

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