Evaluation of Effectiveness of Bioactive Principles of Mucuna pruriens Seeds Using Experimental Models of Depression Associated with Parkinsonism and Associated Neurotransmitter Turnover

J, Galani Varsha; K, Talaviya Hetal

doi:10.21767/2472-0151.100017

Cited by 1 publication

(2 citation statements)

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“…10 The alcoholic extracts of the seeds successfully show antioxidant activity 11 ; it also reduces oxidative stress in tissues. [12][13][14] The analgesic, antipyretic, and anti-inflammatory properties of M. pruriens seed powder evaluated reveal increased inhibition concerning dose. 11,14,15 Phytochemical screening of M. pruriens seed aqueous extract using the high-performance liquid chromatography shows the presence of proanthocyanidin, tannin, gallic acid, quercetin, and phytic acid.…”

Section: Introductionmentioning

confidence: 99%

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Volatile Composition, Toxicity, Analgesic, and Anti-Inflammatory Activities of Mucuna pruriens

Avoseh

Ogunwande²,

Ojenike

et al. 2020

Natural Product Communications

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The volatile constituents, toxicity, antinociception, and anti-inflammatory activities of the essential oil obtained from the leaf of Mucuna pruriens utilis collected from Nigeria are reported. The essential oil was analyzed comprehensively utilizing gas chromatography (GC)-flame ionization detector and GC coupled with mass spectrometry (MS) using the HP-5 column. The antinociceptive and anti-inflammatory assays were analyzed by a hot plate, formalin, and carrageenan-induced edema assays, respectively. The essential oil was obtained in a yield of 0.2% (v/w) calculated on a dry weight basis. A total of 36 compounds representing 94.8% of the oil contents were identified. The oil contained a high content of ( E)-2-hexenal (19.0%), linalool (8.9%), 1-hexanol (6.6%), and trans-dehydroxylinalool oxide (5.2%). The analgesic property of the essential oil was slightly significant ( P < 0.5) only at the third hour for the 400 mg/kg while other doses are less active. The rate of inhibition was moderate (24.1%-54%) during the analgesic phase of the formalin assay. The rate of inhibition at the anti-inflammatory phases of both formalin and carrageenan were significantly high (100%) and P < 0.001 for all the doses during the reaction duration. The potential proinflammatory mechanism might be due to effects on several proinflammatory mediators, including, histamine, serotonin, and bradykinin, and the ability of the essential oils to act as centrally mediated opioid analgesic. Mucuna pruriens essential oils displayed a high anti-inflammation potential and can be used as a potential centrally mediated opioid antagonist against analgesia.

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Section: Introductionmentioning

confidence: 99%

“…10 The alcoholic extracts of the seeds successfully show antioxidant activity 11 ; it also reduces oxidative stress in tissues. 12 -14 The analgesic, antipyretic, and anti-inflammatory properties of M. pruriens seed powder evaluated reveal increased inhibition concerning dose. 11,14,15…”

Section: Introductionmentioning

confidence: 99%