Evaluation of effectiveness of iron-folate supplementation and anthelminthic therapy against anemia in pregnancy— a study in the plantation sector of Sri Lanka

Atukorala, T. M. S.; Silva, L D de; Dechering, W H; Dassenaeike, T S; Perera, Romain S

doi:10.1093/ajcn/60.2.286

Cited by 100 publications

(70 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…He observed that in the iron-supplemented group there was an initial decline in the Hb concentration until about 28 progressive weeks of gestation, but increasing until term. Atukorala et al (1994) also observed an identical trend among plantation workers of Sri Lanka only among those who took one iron and folic acid tablet daily. Their Hb at 32 ± 40 weeks was signi®-cantly (P`0.05) higher than at 14 ± 24 weeks of gestation.…”

Section: Discussionmentioning

confidence: 51%

“…Community-based studies to understand the impact made on the prevalence and mean values of haemoglobin and serum ferritin (SF) concentration in each of the three trimesters are scanty. The available community-based trials (Atukorala et al, 1994) also focused and followed the same groups of women to see the effect of the supplementation. The present communitybased study attempts to understand the changes that could occur in the haematological status among the pregnant women in a rural community in three trimesters with the intervention of iron supplementation, helminthic control and other effective strategies through information, education and communication (IEC).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Can iron status be improved in each of the three trimesters? A community-based study

et al. 2000

View full text Add to dashboard Cite

Objective: Intervention with iron supplementation, deworming, and information, education and communication (IEC) to improve the haematological status among each of the three trimesters of pregnant women in a rural community. Design: A community-based study was carried out using a two-group pre ± post experimental design in a rural community. Setting: Two rural blocks in Vellore district were selected for the study. KV Kuppam block with a population of 120,000 and the adjacent Gudiyatham block with a population of 132,000 served as study and control areas for the study. Subjects: Using a multistage sampling, initially 50% of the panchayats, the local village administrative units, were randomly selected and all pregnant women were the subjects. In the pre-intervention survey 458 and 387 pregnant women had haemoglobin tested and the post-intervention survey covered 403 and 425 pregnant women in the study and control areas, respectively. Similarly serum ferritin was tested in a randomly selected subsample with 254 and 191 pregnant women before intervention and in 216 and 223 pregnant women after intervention in both study and control areas, respectively. Intervention: Iron supplementation and deworming were provided to all pregnant women in the study area from the fourth month of their pregnancy. An intensive information, education and communication was carried out with facts on anaemia and diet modi®cation to each pregnant woman, using a one-to-one approach in the community, and a group method in the mobile clinics. This was carried out for a period of 18 months. Results: A signi®cant decrease in the prevalence of anaemia was found, from 56.1% to 25.07% (P`0.001), 73.4% to 49.2% (P`0.001) and 68.8% to 56.8% (P`0.01) among women in the ®rst, second and third trimesters, respectively, in the intervention area. Signi®cant (P`0.001) increases in the mean haemoglobin of 0.85 gadl (95% CI 10.18 ± 10.84, 11.09 ± 11.63), 0.59 gadl (95% CI 9.98 ± 10.34, 10.55 ± 10.95) and 0.36 gadl (95% CI 9.93 ± 10.33, 10.25 ± 10.73) were also observed in each of the groups. Conclusion: A comprehensive community-based intervention with iron supplementation, helminthic treatment and increase in knowledge using IEC through effective strategies can improve the haematological status of pregnant women in each trimester.

show abstract

Section: Discussionmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Can iron status be improved in each of the three trimesters? A community-based study

et al. 2000

View full text Add to dashboard Cite

show abstract

“…Zinc levels in maternal milk were determined in a similar manner (C.V. 4.9%). Atukorala et al (1994) indicate that the normal limit for serum zinc levels in pregnant women is 8 mmolaL. Other ®gures quoted are 10.7 mmolaL according to Jameson (1975), and 12.2 mmolaL according to Pfeffer et al (1996).…”

Section: Biochemical Studymentioning

confidence: 96%

Zinc levels in maternal milk: the influence of nutritional status with respect to zinc during the third trimester of pregnancy

et al. 1997

View full text Add to dashboard Cite

Objective: To study the relationship between nutritional status with respect to zinc during the third trimester of pregnancy and levels of the same mineral in transition milk (days 13 and 14 of lactation) and mature milk (day 40 of lactation). Design: Longitudinal study. Subjects: A group of 57 healthy, lactating mothers aged between 18 and 35 y (27 AE 3.7) whose pregnancy and labour were attended by the Department of Obstetrics and Gynaecology of Cuenca INSALUD Hospital, Spain. Interventions: Zinc intake during the third trimester was determined by recording the consumption of foods over a ®ve day period and by registering zinc provided by dietary supplements. Zinc levels in maternal serum during this stage of pregnancy, and in transition and mature milk, were determined by atomic absorption spectroscopy. Results: During pregnancy all subjects showed zinc intakes lower than those recommended. Only one pregnant subject took a supplement that provided extra zinc (1 mgad). Subjects with an intake of lower than 50% of that recommended (L) (43.9%) showed signi®cantly lower serum and mature milk zinc levels than did those with higher intakes (H) (56.1%) [12.0 AE 1.5 mmolaL and 28.7 AE 6.2 mmolaL compared to 13.3 AE 2.6 mmolaL and 33.1 AE 8.0 mmolaL respectively]. 56% of L subjects and 28.6% of H subjects showed serum zinc levels of less than 12.2 mmolaL. 8% of L subjects and no H subjects showed less than 11.5 mmolaL of zinc in maternal milk. Conclusions: The diet conditions maternal serum zinc levels during pregnancy and those of milk during lactation. Though all subjects showed intakes clearly below those recommended, low levels in serum or milk were much rarer. These results support the idea that there is a need to reset the limits of normality for serum and milk zinc levels. Further work in this area may con®rm that the present recommended intakes of zinc be modi®ed. Sponsporship: This work was supported by the Fondo de Investigaciones Sanitarias de la Seguridad Social (FISss).

show abstract

“…It has the highest prevalence in the US among women and young children. Women ages [16][17][18][19] have an iron deficiency incidence as high as 19%. Iron deficiency increases in minority populations and is as high as 22% in Hispanic women.…”

Section: Introductionmentioning

confidence: 99%

“…In India 20% of maternal deaths are due to anemia. In the Ivory Coast [17], Sri Lanka, and Sierra Leone, treatment for hookworm improved hemoglobin levels significantly [18,19]. A study involving 3595 children attributed 35% of cases of iron deficiency anemia and 73% of cases of severe iron deficiency anemia to hookworm infection [20].…”

Section: Introductionmentioning

confidence: 99%

Iron deficiency: A concise review

2005

View full text Add to dashboard Cite

Iron deficiency is a major worldwide health problem. There is recent evidence that the anemia is only the last manifestation of the syndrome and that symptoms occur before the anemia is manifest. Advances in outlining the physiology of iron deficiency have been made, gaps remain in the current understanding. While oral iron supplement remains the mainstay, some indications for the intravenous administration have developed. This review will highlight the epidemiology, physiology, clinical presentation, and treatment options. Am.

show abstract

Evaluation of effectiveness of iron-folate supplementation and anthelminthic therapy against anemia in pregnancy— a study in the plantation sector of Sri Lanka

Cited by 100 publications

References 11 publications

Can iron status be improved in each of the three trimesters? A community-based study

Can iron status be improved in each of the three trimesters? A community-based study

Zinc levels in maternal milk: the influence of nutritional status with respect to zinc during the third trimester of pregnancy

Iron deficiency: A concise review

Contact Info

Product

Resources

About