Evaluation of effects of multiple candidate genes (<scp>LEP</scp>, <scp>LEPR</scp>, <scp>MC4R</scp>, <scp>PIK3C3</scp>, and <scp>VRTN</scp>) on production traits in <scp>D</scp>uroc pigs

Hirose, Kensuke; Ito, Tetsuya; Fukawa, Kazuo; Arakawa, Aisaku; Mikawa, Satoshi; Hayashi, Yuzo; Tanaka, Kazuaki

doi:10.1111/asj.12134

Cited by 28 publications

(23 citation statements)

References 24 publications

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“…In a subsequent analysis, Hirose et al . () reported no significant association between the VRTN gene and IMF in the same Duroc population. The biological explanation for the result obtained by Hirose et al .…”

Section: Resultsmentioning

confidence: 88%

“…However, a subsequent report by Hirose et al . () indicated that there was no significant association between VRTN gene polymorphisms and IMF in the same population. Therefore, further study is required to evaluate the effect of VRTN gene polymorphisms on production traits and other economically important traits related to the number of vertebrae in different pig populations.…”

Section: Introductionmentioning

confidence: 91%

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Effect of VRTN gene polymorphisms on Duroc pig production and carcass traits, and their genetic relationships

Nakano

Sato

Uemoto

et al. 2014

Animal Science Journal

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The thoracic vertebral number is associated with body length and carcass traits, and represents one of the most important traits in the pig industry. Recent studies have shown that vertnin (VRTN) gene is associated with variations in the vertebral number in commercial European pigs. However, the genetic relationships and effect of this VRTN gene in pig production and carcass traits remain uncertain. Therefore, we investigated the genetic relationships among traits such as vertebral numbers, carcass weight and length-related traits, and meat production traits, and the effect of VRTN gene polymorphisms on these traits in a Duroc purebred population selected for its meat production traits. Highly positive genetic correlations were obtained between the thoracic vertebral numbers and length-related traits (0.56 to 0.84), whereas low correlations were obtained with production traits and carcass weight (-0.16 to 0.05). VRTN gene polymorphisms indicated that the number of thoracic vertebrae and length-related traits were significantly associated with the VRTN genotype, but had no significant effect on production traits and carcass weight. The results indicate that VRTN gene may be used as an effective selection marker to obtain pigs with high thoracic vertebral numbers and length-related traits, without adversely affecting meat production traits.

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Section: Resultsmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 91%

Effect of VRTN gene polymorphisms on Duroc pig production and carcass traits, and their genetic relationships

Nakano

Sato

Uemoto

et al. 2014

Animal Science Journal

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“…This may be due to different combinations of genes and their effects. The analysis of multiple genes (LEP, LEPR, MC4R, PIK3C3 and VRTN) effects on production traits in Duroc pigs showed independently influence on growth rate and fat deposition (Hirose et al, 2014). We studied the combined effect of the MC4R and GH genes.…”

Section: Discussionmentioning

confidence: 99%

The Single and Combined Effect of MC4R and GH Genes on Productive Traits of Pigs

Getmantseva¹,

Леонова²,

Усатов³

et al. 2017

American Journal of Agricultural and Biological Sciences

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The aim of our work is to identify the single and combined effect of MC4R and GH polymorphism genes on growth and reproduction traits of pigs. The study was carried out on 204 crossbred F1 females (♀Landrace х ♂Large White) of the Breeding Farm in Russia. The analyzed productive traits were: The number of Days to 100-kg (Days to 100 kg), Length of Body (LB), Backfat Thickness (BF) and Number of piglets Born Alive (NBA). The G1426A of MC4R and G316A of GH polymorphism were determined by PCR-RFLP method. The results showed a significant additive effect of MC4R (G1426A) on all analyzed traits and dominant effect on LB and NBA. With better Days to 100 kg associated genotype AA/MC4R, but the best indicators LB, BF and NBA installed for genotype GG/MC4R. The single effect of GH was determined to BF (dominant effect) and NBA (additive effect). The effect of genotype AG/GH on BF was observed in combination with genotypes of MC4R. In our studies we observed only six combinations of MC4R and GH genes instead of nine theoretically expected. The detected genotypes were following: AA/MC4R -AG/GH, AA/MC4R -GG/GH, AG/MC4R -AA/GH, AG/MC4R -AG/GH, AG/MC4R -GG/GH, GG/MC4R -GG/GH. The combination effect is defined for genotype AA/MC4R with genotypes of GH. The best means for all studied productivity traits were observed for the combination AA/MC4R-AG/GH. The combined effect of genotype AG/MC4R with genotypes of GH was not identified, but it was observed independently influence of MC4R on Days to 100 kg and NBA and GH on BF. The genotype GG/MC4R was detected only in combination with GG/GH genotype, which does not allow evaluating the combination effect of other GH genotypes.

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“…In the association analysis performed by Houston et al (2004), the MC4R gene was significantly associated with mean daily gain, daily feed intake and backfat thickness. Hirose et al (2014), by evaluating the effects of candidate genes on production traits in Duroc pigs, detected positive correlations between the mean daily weight gain and backfat thickness of SNPs in the LEPR (c.2002T), MC4R (c.1426G) and PIK3C3 (c.2604C) genes.…”

Section: Mc4r (Snpg1578c>t)mentioning

confidence: 99%

Research Article Association of MC4R, FABP3 and DGAT1 gene polymorphisms with reproductive traits in two domestic pig lines

Gondim¹,

Soares²,

Lugo³

et al. 2019

Genet. Mol. Res.

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MC4R, FABP3 and DGAT1 are important genes related to productive and reproductive traits in pigs, such as food intake, growth rate, back fat thickness reduction and lactation. Selection of pigs for lean meat production may lead to losses in reproductive charcters because reduction of backfat thickness and low feed intake during the lactation phase can affect reproduction. To examine this possibility, we evaluated possible associations of SNPs in the MC4R (SNPg.1,578C>T), FABP3 (SNPg.240T>C) and DGAT1 (SNPg.9,422C>T) genes with the number of weaned piglets, birth weight, total weight of litter at birth, total litter weight at weaning, age at first mating and parity interval in 227 animals of two maternal lines: European and European/Chinese pigs. Specific fragments of the genes under study were amplified by Multiplex ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 18 (3): gmr18139 V.S. Gondim et al. 2 ARMS-PCR and genotyped in an automatic sequencer. SNPs in the MC4R (SNPg.1,578C>T) and FABP3 (SNPg-240T>C) genes showed three genotypic variations in both lines, while the SNP (SNPg.9,422C>T) of the DGAT1 gene had three genotypic variations in European swine and two genotypic variations (homozygotes) in the European/Chinese breed. Polymorphisms of MC4R, FABP3 and DGAT1 genes evaluated by variance analysis had significant associations with the reproductive traits age at first mating and parity interval, while only the DGAT1 gene in the European line was significantly associated with the production traits mean weight at weaning and total litter weight at birth andnd weaning.

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Evaluation of effects of multiple candidate genes (LEP, LEPR, MC4R, PIK3C3, and VRTN) on production traits in Duroc pigs

Cited by 28 publications

References 24 publications

Effect of VRTN gene polymorphisms on Duroc pig production and carcass traits, and their genetic relationships

Effect of VRTN gene polymorphisms on Duroc pig production and carcass traits, and their genetic relationships

The Single and Combined Effect of <i>MC4R</i> and <i>GH</i> Genes on Productive Traits of Pigs

Research Article Association of MC4R, FABP3 and DGAT1 gene polymorphisms with reproductive traits in two domestic pig lines

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