Evaluation of Efficacy of Curcumin as an Add-on therapy in Patients of Bronchial Asthma

Abstract

Background: Bronchial asthma being a chronic inflammatory disease of airways has numerous treatment options none of which have disease modifying properties. Curcumin, a yellow dietary pigment has varied pharmacological activities, prominent among which is an anti-inflammatory activity which may be crucial in bronchial asthma as has been proved by various in vitro and in vivo animal studies. Aims:To determine the efficacy and safety of curcumin as an 'add-on' therapy in patients of bronchial asthma. Settings and Design:This study was conducted on 77 patients of mild to moderate Bronchial asthma who had a documented positive bronchodilator reversibility test with ≥15% improvement in forced expiratory volume one second (FEV1). Materials and Methods:Seventy seven patients were recruited for the study and randomized into either of the two groups, but 17 patients were lost to follow up. Thus Group A -Receiving standard therapy for bronchial asthma for 30d (n=30) and Group B -Receiving standard therapy for bronchial asthma + Cap Curcumin 500mg BD daily for 30d (n=30). The predefined primary endpoints were clinical assessments of dyspnoea, wheezing, cough, chest tightness and nocturnal symptoms, change in the pre-bronchodilator FEV1 during the treatment and hematological improvement. The secondary end points were assessed by the change in the post-bronchodilator FEV1, C-reactive protein (CRP) concentration and incidence of adverse events. Statistical Analysis used:The data was analysed by SPSS 17.0 software using one-way ANOVA or Paired t-test.

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“…Particular interest in the latter has taken center stage, with some interesting findings already reported from both experimental and clinical investigations [17–19]. …”

Developments in the mechanisms of allergy in 2018 through the eyes of Clinical and Experimental Allergy, Part I

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Modulation of Toll-like receptor signaling in innate immunity by natural products

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