Evaluation of Efficacy of Oxytetracycline Oral and Bath Therapies in  Nile Tilapia, Oreochromis niloticus against Aeromonas hydrophila Infection

Julinta, Roy Beryl; Roy, Anwesha; Singha, Jasmine; Abraham, Thangapalam Jawahar; Patil, Prasanna Kumar

doi:10.20546/ijcmas.2017.607.008

Cited by 16 publications

(15 citation statements)

References 15 publications

(17 reference statements)

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“…Ventura and Grizzle [31] produced systemic infections more readily among channel catfish Ictalurus punctatus by abrading their skin prior to exposing the fish to the bacterium. In this study, the therapeutic effects of OTC by two experimental A. caviae infection routes in a similar line with our earlier studies on A. hydrophila [15,16] were found almost the same in Nile tilapia. On day 10 oral OTC-therapy, the AI and IM challenged Nile tilapia recorded 30% and 72% mortalities, respectively.…”

Section: Discussionsupporting

confidence: 92%

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Effects of Oral Oxytetracycline-Therapy on Wound Progression and Healing Following Aeromonas caviae Infection in Nile Tilapia (Oreochromis niloticus L.)

Roy

Abraham

Namdeo

et al. 2019

Braz. arch. biol. technol.

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Effect of oral OTC-therapy against Aeromonas caviae infection by two challenge routes in Nile tilapia are presented • The intramuscular challenge effected high mortalities than abrasion-immersion challenge • The results demonstrated the positive effect of oral OTC-therapy in overcoming the Aeromonas caviae challenge and improving wound healing. • The extent of damage in untreated Nile tilapia lasted longer in both challenge routes 2 Roy, A.; et al.

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Section: Discussionsupporting

confidence: 92%

“…Such studies on finfish cultured in tropical conditions are meagre. In our earlier studies, we evaluated the efficacy of OTC in Nile tilapia challenged with Aeromonas hydrophila [15,16]. This report presented the results of the isolation, identification, and characterization of Aeromonas spp.…”

Section: Introductionmentioning

confidence: 99%

Effects of Oral Oxytetracycline-Therapy on Wound Progression and Healing Following Aeromonas caviae Infection in Nile Tilapia (Oreochromis niloticus L.)

Roy

Abraham

Namdeo

et al. 2019

Braz. arch. biol. technol.

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“…The RPS value in this study was similar or higher than several studies using antibiotics for Aeromonads control in Nile tilapia e.g. RPS of 60% in orally administered with Oxytetracycline 4g/kg/feed per day (Abraham et al, 2017) or RPS 25.9 % in orally fed with Oxytetracycline 60 mg/kg biomass per day (Julinta et al, 2017).…”

Section: Disscussionsupporting

confidence: 81%

Ozone nanobubble treatments improve survivability of Nile tilapia (Oreochromis niloticus) challenged with a pathogenic multidrug-resistantAeromonas hydrophila

Dien

Linh

Sangpo

et al. 2021

Preprint

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Multidrug-resistant (MDR) bacteria has rapidly increased in aquaculture, which highlights the risk of production losses due to diseases and potential public health concerns. Previously, we reported that ozone nanobubbles (NB-O3) were effective at reducing concentrations of pathogenic bacteria in water and modulating fish immunity against pathogens; however, multiple treatments with direct NB-O3 exposures caused alterations to the gills of exposed-fish. Here, we set up a modified recirculation system (MRS) assembled with an NB-O3 device (MRS-NB-O3) to investigate whether MRS-NB-O3 were 1) safe for tilapia (Oreochromis niloticus), 2) effective at reducing bacterial load in rearing water, and 3) improved survivability of Nile tilapia following an immersion challenge with a lethal dose of MDR Aeromonas hydrophila. The results indicated no behavioral abnormalities or mortality of Nile tilapia during the 14-day study using the MRS-NB-O3 system. In the immersion challenge, although high bacterial concentration (~2 × 107 CFU/mL) was used, multiple NB-O3 treatments in the first two days reduced the bacteria between 15.9% to 35.6% of bacterial load in water while bacterial concentration increased 13.1% to 27.9% in the untreated control. There was slight up-regulation of non-specific immune-related genes in the gills of the fish receiving NB-O3 treatments. Most importantly, this treatment significantly improved survivability of Nile tilapia with relative percent survival (RPS) of 64.7 - 66.7% in treated fish and surviving fish developed specific antibody against MDR A. hydrophila. In summary, the result suggests that NB-O3 is a promising alternative to antibiotics to control bacterial diseases, including MDR bacteria, and has high potential for application in recirculation aquaculture system (RAS).

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“…Oxytetracycline is a widely used antibiotic in the aquaculture sector across the world. However, the drug has poor bioavailability following oral administration in many finfish species (Julinta et al, 2017;Rogstad et al, 1991). This was also evident from low concentrations of OTC in plasma and flesh which remained far below the MRL levels recommended by the Codex Alimentarius ( 2018) and European Medicines Agency (1995) in P. hypophthalmus receiving OTC @ 80 mg kg −1 and 240 mg kg −1 body weight.…”

Section: Discussionmentioning

confidence: 99%

“…OTC is recommended for use at the maximum dose regimen of 82.5 mg kg −1 fish per day for 10 days with feed (FDA, 2015; USGS, 2007), although higher doses are also used in finfish due to its poor bioavailability after oral administration (Julinta et al, 2017; Rogstad et al, 1991). Following the USGS (2007) and FDA (2015) recommendations, a dose of 80 mg OTC kg −1 body wt of fish daily for 10 days was taken as the minimum dose of the drug for the establishment of its safety.…”

Section: Introductionmentioning

confidence: 99%

Determination of biosafety of the antibiotic oxytetracycline hydrochloride in Pangasianodon hypophthalmus

Manna

Bera

Das

et al. 2021

Aquaculture Research

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Pangasianodon hypophthalmus is one of the most important aquaculture species in Southeast Asia, with a significant contribution to the world fish basket. Like other crops, the striped catfish suffers from bacterial diseases that demand the use of antibiotics. The present study has evaluated the safety of oxytetracycline, one of the approved and commonly used antibiotics, in this species. Juvenile stages of the fish (31.16 ± 1.03 g) were administered with the antibiotic in feed at the dose rate of 80–800 mg kg−1 body weight daily for 30 days, followed by 10 days of withdrawal observation. Fish health was assessed by the study of behaviour and feed intake, haematology, blood biochemistry, and histopathology. Results showed that up to 30 days of antibiotic treatment resulted in no significant toxic effects in terms of behaviour and fish mortality. However, fish suffered from reduced feed intake and hepatotoxicity evidenced by proliferative and degenerative changes of hepatocytes, and increase in AST and ALT enzyme activities, especially in 400–800 mg kg−1 doses which, however, recovered after withdrawal of the drug. Although few fish died from a bacterial infection at the lowest concentration of the drug used, fish were able to mount adaptive physiological responses best at 80 mg kg−1 fish dosage. The study establishes that in‐feed administration of the antibiotic oxytetracycline @ 80 mg kg−1 fish biomass is safe for therapeutic use in P. hypophthalmus.

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Evaluation of Efficacy of Oxytetracycline Oral and Bath Therapies in Nile Tilapia, Oreochromis niloticus against Aeromonas hydrophila Infection

Cited by 16 publications

References 15 publications

Effects of Oral Oxytetracycline-Therapy on Wound Progression and Healing Following Aeromonas caviae Infection in Nile Tilapia (Oreochromis niloticus L.)

Effects of Oral Oxytetracycline-Therapy on Wound Progression and Healing Following Aeromonas caviae Infection in Nile Tilapia (Oreochromis niloticus L.)

Ozone nanobubble treatments improve survivability of Nile tilapia (Oreochromis niloticus) challenged with a pathogenic multidrug-resistantAeromonas hydrophila

Determination of biosafety of the antibiotic oxytetracycline hydrochloride in Pangasianodon hypophthalmus

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