Evaluation of efficacy of platelet-rich fibrin membrane and bone graft in coverage of immediate dental implant in esthetic zone: An in vivo study

Abstract

Objective: This study compared and evaluated the clinical and radiographic results of guided bone regeneration using platelet-rich fibrin (PRF) and collagen membrane as barrier membrane in immediately placed implants with severe buccal bone defect (with respect to marginal bone level, implant stability quotient [ISQ]), and histological analysis of new bone formation. Materials and Methods: Sixteen implants were placed in patients requiring immediate implant placement and having a buccal wall defect and randomly divided into two groups one receiving PRF membranes and other collagen membrane. The sites were grafted with bone-substitute material in both the groups. After 4 months, at the time of second-stage surgery, implant stability is measured by Osstell Mentor, crestal bone level on mesial and distal sides of implant by digital intraoral periapical, buccal defect clinically by probe and histological analysis of biopsied bone. Results: The results were insignificant and comparable in both the groups when comparison was made between the groups. The mean buccal defect, mean values of average ISQ, crestal bone level in both the groups at baseline and after 4 months were compared. No significant difference between both the groups was found after 4 months. Bone quality seemed to be equal in both groups after histological analysis. Within the limits of the study, both the groups had shown similar results in all criteria. Conclusion: Within the limitation of the study, it can be concluded that both the treatment modalities are successful in terms of buccal defect reduction, stability, and increase in crestal bone level.

Effect of Platelet Concentrates on Marginal Bone Loss of Immediate Implant Procedures: A Systematic Review and Meta-Analysis

“…After reading the full text of those 39 papers, 13 were discarded for not analyzing IIP, 6 for an absence or inadequate control group, 6 for being retrospective observational studies or case reports, 3 studies related to sinus lift, two for not assessing MBL and one for performing flapless procedures. Finally, 8 studies were included in our systematic review [ 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ] ( Figure 1 ). Only two of the three groups of Alam et al [ 38 ] study were considered in this review (PCs + bone graft group vs. only bone graft group).…”

“…The selected articles were published between 2015 and 2020 [ 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ]. One study was a CCT [ 32 ] and seven studies were RCTS [ 33 , 34 , 35 , 36 , 37 , 38 , 39 ]. Three of the selected studies had a split-mouth design [ 32 , 33 , 37 ].…”

“…One study was a CCT [ 32 ] and seven studies were RCTS [ 33 , 34 , 35 , 36 , 37 , 38 , 39 ]. Three of the selected studies had a split-mouth design [ 32 , 33 , 37 ]. Four of them were performed in India [ 35 , 36 , 38 , 39 ], one in Syria [ 32 ], one in Saudi Arabia [ 33 ], one in Turkey [ 37 ] and one in Egypt [ 39 ] ( Table 2 ).…”

“…The age ranged from 18 to 55 years, there being 32 males and 23 females. Systemically healthy patients were included in every study [ 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ]. Regarding the inclusion of smokers, six studies excluded smokers [ 32 , 33 , 35 , 37 , 38 , 39 ], one included smokers of less than 10 cigarettes per day [ 36 ] and one included smokers [ 34 ].…”

“…Systemically healthy patients were included in every study [ 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ]. Regarding the inclusion of smokers, six studies excluded smokers [ 32 , 33 , 35 , 37 , 38 , 39 ], one included smokers of less than 10 cigarettes per day [ 36 ] and one included smokers [ 34 ]. Concerning the periodontal status, Al Nashar et al [ 32 ] included patients with chronic periodontitis in the mandibular anterior region, Khan et al [ 35 ] excluded patients with severe periodontal bone loss, and six studies [ 33 , 34 , 36 , 37 , 38 , 39 ] included patients with good oral hygiene.…”