Evaluation of Efficiency of Dyes in Detection of Cancer Cells

Abstract

Introduction: The early detection of the cancer will dramatically improve the prognosis. There are many diagnostic aids that can be employed for screening. Hence, in our study, we aim to evaluate the efficiency of dyes in detection of cancer cells. Materials and Methods: We piloted a prospective clinical study among 30 subjects to detect the efficiency of two dyes—Lugol's iodine and toluidine blue. They were grouped equally for potentially malignant and malignant lesions. The areas were analyzed for the diagnostic accuracy of the dyes using the histopathological examination and compared using chi square test deliberating P < 0.05 as significant. Results: We observed that both the dyes showed a diagnostic accuracy of over 90% when used alone or in combination. Both the dyes had greater sensitivity while specificity was 20%. Conclusion: The combination of these two dyes can be used as an efficient screening aid for the identification of the cancer cells.

Evaluation of Usage of Different Diagnostic Aids for Oral Cancer by Oral and Maxillofacial Surgeons: An Original Research

“…Toluidine blue staining and brush biopsies increase sensitivity and specificity. [ 6 7 8 9 10 ] Current study’s utilization rates match the evidence, indicating these aids improve diagnostic accuracy. Autofluorescence imaging and optical coherence tomography are used less, suggesting a gap between research and practice.…”

“…It has been shown to detect early oral malignancies and potentially malignant lesions. [ 7 8 9 ] Oral and maxillofacial surgeons use it as a supplement to visual inspection and biopsies, judging by its moderate use.…”