Evaluation of emerging biomarkers of renal damage and exposure to aflatoxin-B1 in Mexican indigenous women: a pilot study

León-Martínez, Lorena Díaz de; Dı́az-Barriga, Fernando; Barbier, Olivier; Ortíz, Dora Linda Guzmán; Ortega-Romero, Manolo; Pérez‐Vázquez, Francisco Javier; Flores-Ramírez, Rogelio

doi:10.1007/s11356-019-04634-z

Cited by 42 publications

(29 citation statements)

References 79 publications

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“…The introduction of Ultra-LC (UHPLC), characterized by uniform column packing material with a particle size of less than 2-3 µm and new pumps and detectors, has represented an improvement, given that it achieves shorter run times, reduces solvent consumption and improves chromatographic resolution and efficiency. UHPLC was reported in 42.8% of the chromatographic methods summarized in this review [48,53,58,64,65,68,69,[81][82][83].…”

Section: Mycotoxin Determination In Human Blood Plasma and Serummentioning

confidence: 99%

“…However, sample preparation for this technique is time-consuming [70]. Liquid chromatography coupled with fluorescence detection (LC-FLD) was used frequently (24% of the methods reviewed) [54,55,57,58,81,[85][86][87][88][89][90][91][92].…”

Section: Mycotoxin Determination In Human Blood Plasma and Serummentioning

confidence: 99%

“…Regarding the mass analyzers, the triple quadrupole (QqQ) and the quadrupole-ion trap (QTrap) were the most commonly used (57% and 32%, respectively). Recent advances in high-resolution mass spectrometry (HRMS) [48,49,81] and the use of ulti-mycotoxin biomarker databases have improved the identification and validation of iomarkers of exposure and revealed new mycotoxin metabolites [43]. These studies have ontributed to a more in-depth knowledge of the biomarkers of exposure in humans.…”

Section: Mycotoxin Determination In Human Blood Plasma and Serummentioning

confidence: 99%

“…Recently, excellent reviews have been published regarding the evelopment and the applicability of biosensors for mycotoxin determination [94][95][96][97][98]. Recent advances in high-resolution mass spectrometry (HRMS) [48,49,81] and the use of multi-mycotoxin biomarker databases have improved the identification and validation of biomarkers of exposure and revealed new mycotoxin metabolites [43]. These studies have contributed to a more in-depth knowledge of the biomarkers of exposure in humans.…”

Section: Mycotoxin Determination In Human Blood Plasma and Serummentioning

confidence: 99%

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Human Biomonitoring of Mycotoxins in Blood, Plasma and Serum in Recent Years: A Review

Arce-López

Lizarraga

Vettorazzi

et al. 2020

Toxins

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This manuscript reviews the state-of-the-art regarding human biological monitoring (HBM) of mycotoxins in plasma, serum and blood samples. After a comprehensive and systematic literature review, with a focus on the last five years, several aspects were analyzed and summarized: (a) the biomarkers analyzed and their encountered levels, (b) the analytical methodologies developed and (c) the relationship between biomarker levels and some illnesses. In the literature reviewed, aflatoxin B1-lysine (AFB1-lys) and ochratoxin A (OTA) in plasma and serum were the most widely studied mycotoxin biomarkers for HBM. Regarding analytical methodologies, a clear increase in the development of methods for the simultaneous determination of multiple mycotoxins has been observed. For this purpose, the use of liquid chromatography (LC) methodologies, especially when coupled with tandem mass spectrometry (MS/MS) or high resolution mass spectrometry (HRMS) has grown. A high percentage of the samples analyzed for OTA or aflatoxin B1 (mostly as AFB1-lys) in the reviewed papers were positive, demonstrating human exposure to mycotoxins. This review confirms the importance of mycotoxin human biomonitoring and highlights the important challenges that should be faced, such as the inclusion of other mycotoxins in HBM programs, the need to increase knowledge of mycotoxin metabolism and toxicokinetics, and the need for reference materials and new methodologies for treating samples. In addition, guidelines are required for analytical method validation, as well as equations to establish the relationship between human fluid levels and mycotoxin intake.

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Section: Mycotoxin Determination In Human Blood Plasma and Serummentioning

confidence: 99%

Section: Mycotoxin Determination In Human Blood Plasma and Serummentioning

confidence: 99%

Section: Mycotoxin Determination In Human Blood Plasma and Serummentioning

confidence: 99%

Section: Mycotoxin Determination In Human Blood Plasma and Serummentioning

confidence: 99%

See 2 more Smart Citations

Human Biomonitoring of Mycotoxins in Blood, Plasma and Serum in Recent Years: A Review

Arce-López

Lizarraga

Vettorazzi

et al. 2020

Toxins

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show abstract

“…studies to investigate the combinations of biomarkers that would provide complementary information to have the most accurate and precise indication on the extent of exposure to predict the disease risk and outcome[129][130]. Success of this approach is contingent to the availability of appropriate and easy-to-use analytical techniques that can apply to all biomarkers in a composite set at once.…”

mentioning

confidence: 99%

Retrospective and Prospective Look at Aflatoxin Research and Development from a Practical Standpoint

Benkerroum

2019

Preprint

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Among the array of structurally and toxicologically diverse mycotoxins, aflatoxins have attracted the most interest of scientific research due to their high toxicity and incidence in foods and feeds. Despite the undeniable progress made in various aspects related to aflatoxins, the ultimate goal consisting of reducing the associated public health risks worldwide is far from being reached due to multiplicity of social, political, economic, geographic, climatic, and development factors. However, a reasonable degree of health protection is attained in industrialized countries owing to their scientific, administrative, and financial capacities allowing them to use high-tech agricultural management systems. Less fortunate situation exists in equatorial and sub-equatorial developing countries mainly practicing traditional agriculture managed by smallholders for subsistence, and where the climate is suitable for mould growth and aflatoxin production. A situation that worsens by the climatic change being increasingly suitable for aflatoxigenic mold growth and toxin production. Accordingly, it is difficult to harmonize the regulatory standards of aflatoxins worldwide, which prevents agri-foods of developing countries from access to the market of industrialized countries. To tackle the multi-facetted aflatoxin problems, actions should be taken collectively by the international community involving scientific research, technological and social development, environment protection, awareness promotion, etc. International cooperation should foster technology transfer and exchange of pertinent technical information. This review presents the main historical discoveries leading to our present knowledge on aflatoxins and the challenges that should be addressed presently and in the future at various levels to ensure higher health protection for everybody. In short, it aims to elucidate where we come from and where we should go in terms of aflatoxin research/development.

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Exposure Assessment of Aflatoxins in Humans

et al. 2021

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Evaluation of emerging biomarkers of renal damage and exposure to aflatoxin-B1 in Mexican indigenous women: a pilot study

Cited by 42 publications

References 79 publications

Human Biomonitoring of Mycotoxins in Blood, Plasma and Serum in Recent Years: A Review

Human Biomonitoring of Mycotoxins in Blood, Plasma and Serum in Recent Years: A Review

Retrospective and Prospective Look at Aflatoxin Research and Development from a Practical Standpoint

Exposure Assessment of Aflatoxins in Humans

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