Evaluation of endogenous intoxication indicators in the dynamics of experimental periodontitis and immobilization stress

Abstract

The aim of our work was to investigate the peculiarities of changes in endogenous intoxication rates: medium mass molecules (MMM) and erythrocyte intoxication index (EII) in the blood of guinea pigs in the formation of combined pathology - experimental periodontitis (EP) and immobilization stress (IS).The results of biochemical studies showed that at all stages of development of combined pathology - experimental periodontitis and immobilization stress there is a consistent increase in the degree of endogenous intoxication, which dominated on the 15th day of the experiment, namely increased content of medium mass molecules (МMМ254 , MMM280) and EII in the blood by 58.5% (p≤0.05), 80.3% (p≤0.05) and 95.7% (p≤0.05), respectively, compared with the first group of animals is a clear manifestation of the formation of endogenous intoxication. These changes are obviously the result of insufficient elimination of toxic products on the background of the inflammatory process in periodontal tissues and stress.

The role of middle-weight molecules and the detoxication activity of mixed saliva albumin in the development of periodontal pathology in oil refinery workers

“…The development of periodontitis is accompanied by oxidative stress, which is characterized by an increase in the intensity of lipid peroxidation (LPO), which leads to impaired lipid metabolism, destruction of cell membranes and impaired metabolism in the oral cavity and the development of endogenous intoxication [10,[15][16][17][18][19][20][21][22][23][24][25][26][27].…”

“…Among the criteria for endogenous intoxication, special attention is paid to molecules of average mass [9,19]. Serum albumin (SA) is the most abundant protein in plasma and mixed saliva, and its function is important for maintaining the body's homeostatic balance.…”