Evaluation of endometrial activin A secretion for prediction of pregnancy after intrauterine insemination

Florio, Pasquale; Bruni, L; Galleri, Letizia; Reis, Fernando M.; Borges, Lavínia E.; Bocchi, Caterina; Litta, Pietro; Leo, Vincenzo De

doi:10.1016/j.fertnstert.2008.12.125

Cited by 26 publications

(18 citation statements)

References 34 publications

(39 reference statements)

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“…Elevated activin concentrations have been linked to reduced adhesion of the blastocyst to the LE (Stoikos et al 2008). However, others have found higher concentrations of activin A in uterine fluid collected during the periovulatory period in women who became pregnant after intrauterine insemination compared to those that failed to establish a pregnancy (Florio et al 2010). Moreover, using semi-quantitative immunohistochemical techniques, Prakash et al (2006) observed reduced staining for both activin A and FST in women with recurring miscarriages.…”

Section: Discussionmentioning

confidence: 99%

Activin A and follistatin during the oestrous cycle and early pregnancy in ewes

O’Connell¹,

McNatty²,

Hurst³

et al. 2016

Journal of Endocrinology

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The activin pathway has been postulated to be involved in regulation of multiple reproductive processes important for survival of the conceptus. These processes include luteinisation of the follicular cells and thus function of the corpus luteum, early embryo development and uterine function including implantation of the conceptus. Therefore, the aim of the current study was to determine whether the concentrations of activin A and follistatin (FST), an activin-binding protein, differed between ewes with a lifetime history of enhanced or reduced embryonic survival (ES). The mRNAs encoding FST and activin A (inhibin beta A subunit; INHBA) were present in the uterus and abundant in the uterine luminal or glandular epithelia by day 18 of gestation. A peak of activin A was observed in the systemic circulation around the time of oestrus, and activin A concentrations were elevated in animals with reduced ES during the oestrous cycle and early gestation. Concentrations of activin A in uterine fluid were approximately twofold greater on day 16 of gestation in ewes with reduced ES compared to those with enhanced ES. No consistent differences in FST were observed between these groups. Treatment of luteinising ovine granulosa cells with activin A in vitro suppressed progesterone secretion providing evidence of a potential pathway whereby increased concentrations of activin A may decrease ES.

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Section: Discussionmentioning

confidence: 99%

Activin A and follistatin during the oestrous cycle and early pregnancy in ewes

O’Connell¹,

McNatty²,

Hurst³

et al. 2016

Journal of Endocrinology

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“…Moreover, it was also suggested that endometrial activin A is somehow related to implantation not only by inducing decidualization, but also by regulating uterine matrix metalloproteinases, with potential interactions during decidualization [15]. The local role of activin A with respect to implantation has been recently emphasized [12], suggesting that its local secretion may signal the presence of a receptive endometrium, as revealed by recent data demonstrating that an adequate local secretion of activin A is a prerequisite for endometrial receptivity [7]. The reported increase of endometrial activin A expression and secretion at the time of blastocyst attachment [7,19] may have an important role as a local endometrial phenomenon involved in the fine tuning of trophoblast growth and differentiation to enter the invasive pathway, as well as embryo implantation [20,21].…”

Section: Discussionmentioning

confidence: 99%

“…The local role of activin A with respect to implantation has been recently emphasized [12], suggesting that its local secretion may signal the presence of a receptive endometrium, as revealed by recent data demonstrating that an adequate local secretion of activin A is a prerequisite for endometrial receptivity [7]. The reported increase of endometrial activin A expression and secretion at the time of blastocyst attachment [7,19] may have an important role as a local endometrial phenomenon involved in the fine tuning of trophoblast growth and differentiation to enter the invasive pathway, as well as embryo implantation [20,21]. In support of this hypothesis is the evidence that activin A is able to regulate the differentiation of proliferative cytotrophoblast into extravillous invasive trophoblast cells of the anchoring villi [7] and, that when added to in-vitro cultured bovine embryos it enhances the expression of genes related to blastocyst hatching and implantation [22].…”

Section: Discussionmentioning

confidence: 99%

“…With respect to their putative role in implantation, it was previously demonstrated that an adequate secretion of activin A is related to successful implantation [7] and, that activin A is also able to induce differentiation of proliferative cytotrophoblast into extravillous invasive trophoblast cells of the anchoring villi [8], an other mechanism relevant to implantation. To further underline the involvement of activin A pathway in mechanisms leading to successful implantation are the data reporting that the endometrial expression of activin bA subunit mRNA is reduced in EP [4] and, that when measured in bloodstream of patients with early pregnancies of unknown location (PUL), women with lowest activin A concentrations are at highest risk of having EP [5].…”

Section: Introductionmentioning

confidence: 99%

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Serum activin A levels are lower in tubal than intrauterine spontaneously conceived pregnancies

Florio

Reis

Battista

et al. 2011

Gynecological Endocrinology

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“…The previous studies which have been based on regression analysis only have considered the weights of the independent features to predict the overall pregnancy probability and they have not assessed the interconnection among the features [11][12][13][14][15][16][17]. Besides, the number of the patients have been studied in the previous researches has been small, these studies have suffered from the lack of statistical power [17,18]. Also, the AUC performance of the previously proposed models for predicting IUI outcome have been low [12].…”

Section: Outcome Predictionmentioning

confidence: 99%

CNFE-SE: A novel hybrid approach combining complex network-based feature engineering and stacked ensemble to predict the success of Intrauterine Insemination and ranking the features

Ranjbari

Khatibi

Dizaj

et al. 2020

Preprint

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Background: Intrauterine Insemination (IUI) outcome prediction is a challenging issue with which the assisted reproductive technology (ART) practitioners are dealing. Predicting the success or failure of IUI based on the couples' features can assist the physicians to make the appropriate decision for suggesting IUI to the couples or not and/or continuing the treatment or not for them. The large number of studies that have been focused on predicting the IVF and ICSI outcome by machine learning algorithms. But, to the best of our knowledge, a few studies have been focused on predicting the outcome of IUI. The main aim of this study is to develop an automatic classification and feature scoring method to predict intrauterine insemination (IUI) outcome and ranking of the most significant features, based on patients' cycle’s characteristics under IUI treatment.Methods: For this purpose, a novel hybrid approach combining complex network-based feature engineering and stacked ensemble (CNFE-SE) is proposed. Three complex networks are extracted considering the patients' data similarities. The feature engineering step is performed on the complex networks. The original feature set and/or the features engineered are fed to the proposed stacked ensemble to classify and predict IUI outcome for couples per IUI treatment cycle. Our study is a retrospective study of a 5-year couples' data undergoing IUI. Data is collected from Reproductive Biomedicine Research Center, Royan Institute for 8,360 couples who underwent 11,255 IUI cycles were included. Results: Experimental results show that the proposed method outperforms the compared methods with AUC of 0.84 ± 0.01, sensitivity of 0.79 ± 0.01, specificity of 0.91 ± 0.01, and accuracy of 0.85 ± 0.01 for the prediction of IUI outcome. Conclusions: The most important predictors for predicting IUI outcome are semen parameters (sperm motility and concentration) as well as female BMI.

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Evaluation of endometrial activin A secretion for prediction of pregnancy after intrauterine insemination

Cited by 26 publications

References 34 publications

Activin A and follistatin during the oestrous cycle and early pregnancy in ewes

Activin A and follistatin during the oestrous cycle and early pregnancy in ewes

Serum activin A levels are lower in tubal than intrauterine spontaneously conceived pregnancies

CNFE-SE: A novel hybrid approach combining complex network-based feature engineering and stacked ensemble to predict the success of Intrauterine Insemination and ranking the features

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