Evaluation of endothelial dysfunction and the possibility of its correction at the present stage in patients with cardiovascular diseases

Samolyuk, M O; Grigorieva, N. Yu.

doi:10.18087/cardio.2524

Cited by 5 publications

(2 citation statements)

References 43 publications

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“…Так, площадь под ROC-кривой, соответствующей взаимосвязи концентрации ИС и вероятности расширения плечевой артерии менее 10 % (как косвенного показателя наличия у пациента эндотелиальной дисфункции) после пробы с эндотелийзависимой вазодилатацией, составила 0,64±0,07 (95 % ДИ = 0,5-0,8). Полученная модель была статистически значимой (p=0,04) [17].…”

Section: таблица 5 параметры почечного кровотока у пациентов 1-й и 2-й групп Table 5 Renal Blood Fl Ow Parameters In Patients Of the 1st unclassified

The Role of Uremic Intoxication in the Development of Cardiovascular Remodeling in Patients with Chronic Kidney Disease Stages 3a-5d

Гасанов

Kolomyitseva

Батюшин

2021

Arhivʺ vnutrennej mediciny

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In recent decades, the prevalence of chronic kidney disease (CKD) in the population has a clear upward trend. This is due, first of all, to an increase in the frequency of occurrence of the main factors leading to its development: diabetes mellitus and arterial hypertension. The progression of CKD against the background of the action of these factors leads to a steady loss of the kidneys of their filtration capacity and the development of complications associated with this process. These include, first of all, metabolic and acid-base disorders, electrolyte abnormalities, uremic intoxication, overhydration, protein-energy wasting, sarcopenia and others. Most of them are involved in the development of endothelial dysfunction and the formation of cardiovascular remodeling (CVR), as a key component of the cardiorenal continuum. At the same time, there is a mutual negative influence of pathology of the cardiovascular system on renal function and manifestations of CKD on cardiovascular hemodynamics. This “vicious circle” leads to the development of end-stage renal disease and an increase in cardiovascular risk and mortality from diseases of the circulatory system in patients with advanced stages of CKD. In this connection, this work is devoted to the study of the role of uremic intoxication and, in particular, indoxyl sulfate, in the development of CVR in patients with CKD at different stages of the disease.

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The Role of Uremic Intoxication in the Development of Cardiovascular Remodeling in Patients with Chronic Kidney Disease Stages 3a-5d

Гасанов

Kolomyitseva

Батюшин

2021

Arhivʺ vnutrennej mediciny

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“…Physical inactivity and obesity have been linked to an increased prevalence of vascular diseases [1,2], In recent years, endothelial dysfunction (ED) has increased in the population [3]. ED is defined as an abnormality of the vascular system that serves as a predictor of cardiovascular events [4], Consequently, monitoring vascular function has gained significant importance in the prevention of vascular events [5].…”

Section: Introductionmentioning

confidence: 99%

Association between Fractional Oxygen Extraction from Resting Quadriceps Muscle and Body Composition in Healthy Men

Yáñez-Sepúlveda,

Olivares-Arancibia,

Cortés-Roco

et al. 2023

JFMK

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This study aimed to associate body composition with fractional oxygen extraction at rest in healthy adult men. Fourteen healthy adults (26.93 ± 2.49 years) from Chile participated. Body composition was assessed with octopole bioimpedance, and resting muscle oxygenation was evaluated in the vastus lateralis quadriceps with near-infrared spectroscopy (NIRS) during a vascular occlusion test, analyzing the muscleVO2, resaturation velocity during reactive hyperemia via the muscle saturation index (%TSI), and the area above the curve of HHb (AACrep). It was observed that the total and segmented fat mass are associated with lower reoxygenation velocities during hyperemia (p = 0.008; β = 0.678: p = 0.002; β = 0.751), and that the total and segmented skeletal muscle mass are associated with higher reoxygenation velocities during hyperemia (p = 0.020; β = −0.614: p = 0.027; β = −0.587). It was also observed that the total and segmented fat mass were associated with a higher area above the curve of HHb (AACrep) during hyperemia (p = 0.007; β = 0.692: p = 0.037; β = 0.564), and that total and segmented skeletal muscle mass was associated with a lower area above the curve of HHb (AACrep) during hyperemia (p = 0.007; β = −0.703: p = 0.017; β = −0.632). We concluded that fat mass is associated with lower resaturation rates and lower resting fractional O2 extraction levels. In contrast, skeletal muscle mass is associated with higher resaturation rates and fractional O2 extraction during reactive hyperemia. The AACrep may be relevant in the evaluation of vascular adaptations to exercise and metabolic health.

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The effect of antioxidant therapy on some pathogenetic factors of primary open-angle glaucoma

Malishevskaya,

Filippova

2023

Vestn. oftal'mol.

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Evaluation of endothelial dysfunction and the possibility of its correction at the present stage in patients with cardiovascular diseases

Cited by 5 publications

References 43 publications

The Role of Uremic Intoxication in the Development of Cardiovascular Remodeling in Patients with Chronic Kidney Disease Stages 3a-5d

The Role of Uremic Intoxication in the Development of Cardiovascular Remodeling in Patients with Chronic Kidney Disease Stages 3a-5d

Association between Fractional Oxygen Extraction from Resting Quadriceps Muscle and Body Composition in Healthy Men

The effect of antioxidant therapy on some pathogenetic factors of primary open-angle glaucoma

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