1984
DOI: 10.1093/ajcp/82.3.323
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Evaluation of Enzyme Immunoassay for Anti-HBc IgM in the Diagnosis of Acute Hepatitis B Virus Infection

Abstract: Corzyme-MTM (Abbott Laboratories, North Chicago, IL), a newly introduced kit for the measurement of serum IgM antihepatitis B core antigen by enzyme immunoassay, was evaluated for the diagnosis of acute B-viral hepatitis (AVH-B). The study included 175 acute viral hepatitis patients with transient hepatitis B surface antigen (HBsAg). Sera from 160 were tested on multiple occasions until their HBsAg cleared. IgM anti-HBc was found in 171 of 175 patients (98.4%) during the acute phase. The serum samples from 42 … Show more

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Cited by 18 publications
(15 citation statements)
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“…Very important differences in HBV‐DNA, HBeAg and AFP, as well as IgM anti‐HBc, between the two groups have been observed in our study. When used singly, the diagnostic power for ASL‐HB of 1:10 000 IgM anti‐HBc was comparable to what has been reported, 4–6 whereas that of HBV‐DNA <10 5 copies/mL was poorer than that of HBV‐DNA <0.5 pg/mL (95.9% sensitivity and 86.6% specificity) in Kumar et al . 's study 7 .…”
Section: Discussionsupporting
confidence: 66%
“…Very important differences in HBV‐DNA, HBeAg and AFP, as well as IgM anti‐HBc, between the two groups have been observed in our study. When used singly, the diagnostic power for ASL‐HB of 1:10 000 IgM anti‐HBc was comparable to what has been reported, 4–6 whereas that of HBV‐DNA <10 5 copies/mL was poorer than that of HBV‐DNA <0.5 pg/mL (95.9% sensitivity and 86.6% specificity) in Kumar et al . 's study 7 .…”
Section: Discussionsupporting
confidence: 66%
“…Detection of anti‐HBc IgM in serum samples was used for the discrimination between acute and chronic HBV infections was measured in the serum samples of all chronic HBV‐infected patients using ELISA technique according to the protocol of the manufacturer (Calbiotech Co., Spring Valley, CA) via ELx808™ Absorbance Microplate Reader (Biotek Instruments Inc., Winooski, VT).…”
Section: Methodsmentioning
confidence: 99%
“…20 HBV and HDV serum markers were sought with a commercial immunoenzymatic assay (Abbott Laboratories, North Chicago, IL for HBsAg, anti-HBs, and anti-HBc, and DiaSorin, Saluggia, VC, Italy, for HBeAg, anti-HBe, anti-HDV immunoglobulin G [IgG] and anti-HDV IgM). Anti-HBc IgM was sought by both immunoenzymatic assay (Abbott Laboratories), which detects only high titres of antibody (sensitivity of 92% to 100% and a specificity of 96% to 100%), [21][22][23][24] and a streptavidine/biotin-binding chemiluminescence assay, which detects the anti-HBc IgM serum concentration (OrthoClinical Diagnostics, Raritan, NJ), as previously reported. 25 The anti-HCV antibody was sought with a third generation commercial immunoenzymatic assay (Ortho Diagnostic Systems, Neckargemund, Germany).…”
Section: Methodsmentioning
confidence: 99%