Evaluation of Ergocalciferol or Cholecalciferol Dosing, 1,600 IU Daily or 50,000 IU Monthly in Older Adults

Binkley, Neil; Gemar, Dessa; Engelke, Jean A.; Gangnon, Ronald E.; Ramamurthy, Rekha; Krueger, Diane; Drezner, Marc K.

doi:10.1210/jc.2010-0015

Cited by 158 publications

(150 citation statements)

References 33 publications

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“…Ergocalciferol or vitamin D 2 can also be used as a supplement, however the studies show that, as its halflife is a little shorter than the one of D 3 , it should be used preferentially daily (83). Be sides that, some laboratory methods that test 25(OH) D recog nize only 25(OH)D 3 , what can bring problems for the control of plasma levels when vitamin D 2 is used for supplementation.…”

Section: What Are the Effects On Bone Metabolism?mentioning

confidence: 99%

Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D

Maeda

Borba

Camargo

et al. 2014

Arq Bras Endocrinol Metab

228

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Objective: The objective is to present an update on the diagnosis and treatment of hypovitaminosis D, based on the most recent scientific evidence. Materials and methods: The Department of Bone and Mineral Metabolism of the Brazilian Society of Endocrinology and Metabology (SBEM) was invited to generate a document following the rules of the Brazilian Medical Association (AMB) Guidelines Program. Data search was performed using PubMed, Lilacs and SciELO and the evidence was classified in recommendation levels, according to the scientific strength and study type. Conclusion: A scientific update regarding hypovitaminosis D was presented to serve as the basis for the diagnosis and treatment of this condition in Brazil.

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Section: What Are the Effects On Bone Metabolism?mentioning

confidence: 99%

Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D

Maeda

Borba

Camargo

et al. 2014

Arq Bras Endocrinol Metab

228

View full text Add to dashboard Cite

show abstract

“…On the other hand, literature data indicate that vitamin D3 is more effective in increasing 25(OH) VitD levels than vitamin D2. [127][128][129][130] Clearly, the optimal level of vitamin D in female fertility and the type of supplements required for the treatment of vitamin D deficiency are two significant issues which merit further research and need to be addressed.…”

Section: Vitamin D Status and Female Fertilitymentioning

confidence: 99%

Vitamin D and aspects of female fertility

Voulgaris

Papanastasiou

Piaditis

et al. 2017

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The role of vitamin D in female reproduction has been intensively examined over the last few decades. A large body of evidence suggests that vitamin D might have beneficial effects on metabolic/hormonal parameters of PCOS and endometriosis, while it appears to be associated with IVF outcomes. However, due to the heterogeneity among observational and interventional studies, no cause-effect relationship has yet been established. The aim of this review is to analyze recent in vitro animal and human studies which examined the association of vitamin D with disease entities affecting female fertility potential. Recent research data strongly imply that vitamin D is implicated in female reproduction and might represent a beneficial and inexpensive therapeutic approach, in combination with first-line medical treatments, to female infertility.

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“…The 25(OH)D3 response to vitamin D supplementation varies markedly between individuals, and a significant proportion of patients may have persistent suboptimal levels despite supplementation [12][13][14][15][16][17]. Furthermore, the relationship between circulating 25(OH)D3 concentrations and clinical outcomes such as osteoporosis and fracture risk may differ between racial groups, raising the question of whether 25(OH)D3 provides a reliable estimate of vitamin D status in all populations [18,19].…”

Section: Introductionmentioning

confidence: 99%

Impact of a single oral dose of 100,000 IU vitamin D3 on profiles of serum 25(OH)D3 and its metabolites 24,25(OH)2D3, 3-epi-25(OH)D3, and 1,25(OH)2D3 in adults with vitamin D insufficiency

Saleh

Tang

Gawinecka

et al. 2017

Clinical Chemistry and Laboratory Medicine (CCLM)

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Background: We investigate the effect of a high dose of vitamin D3 on circulating concentrations of 25(OH) D3 and its metabolites 24,25(OH) 2 D3, 3-epi-25(OH) D3, and 1,25(OH) 2 D3 in healthy individuals with selfperceived fatigue and vitamin D insufficiency [25(OH) D3 <50 nmol/L]. Methods: One hundred and seven study participants (age 20-50 years) were randomized to receive a single 100,000 IU dose of vitamin D3 (n = 52) or placebo (n = 55). Vitamin D metabolite concentrations in serum were measured before, and 4 weeks after, supplementation. Results: Overall, 52% of participants receiving vitamin D3 attained a serum 25(OH)D3 level >75 nmol/L. Among individuals who received vitamin D3, there were significant increases in serum concentrations of 25(OH)D3 and its metabolites 24,25(OH) 2 D3, 3-epi-25(OH)D3, and 1,25(OH) 2 D3 at 4 weeks; however, inter-individual variability in these changes was substantial. Positive correlations between serum 25(OH)D3 and 24,25(OH) 2 D3 and 3-epi-25(OH)D3, and a significant negative correlation between serum 1,25(OH) 2 D3 and 3-epi-25(OH)D3, were found 4 weeks after supplementation. The 24,25(OH) 2 D3/25(OH)

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Evaluation of Ergocalciferol or Cholecalciferol Dosing, 1,600 IU Daily or 50,000 IU Monthly in Older Adults

Cited by 158 publications

References 33 publications

Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D

Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D

Vitamin D and aspects of female fertility

Impact of a single oral dose of 100,000 IU vitamin D3 on profiles of serum 25(OH)D3 and its metabolites 24,25(OH)2D3, 3-epi-25(OH)D3, and 1,25(OH)2D3 in adults with vitamin D insufficiency

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