Evaluation of Estrogenic Activity of the Concentrated Solution and Dried Powder of Pomegranate (<i>Punica granatum</i>) Juice

Im, Sungbin; Ku, Sae Kwang; Park, Mi-Ryeong; Kim, Jong Lae

doi:10.52361/fsbh.2021.1.e29

Cited by 1 publication

(2 citation statements)

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“…These results suggest that pomegranate concentrates are ERindependent for both direct and indirect mechanisms to alleviate postmenopausal syndrome (Im et al, 2021;Rowe & Baber, 2021).…”

Section: Discussionmentioning

confidence: 77%

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Pomegranate effects on the health aspects of women during peri‐ and postmenopause: A systematic review and meta‐analysis

Moeini,

Shirafkan,

Gorji

2023

Phytotherapy Research

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Pomegranate is widely used to preserve human health and help prevent many kinds of diseases. This study aims to review and assess the effects of pomegranate on women's health during and after menopause. PubMed, Web of science, Cochrane, Scopus, and Google Scholar were searched up to the end of 2022 with no language or study type restriction. All types of clinical research studies (randomized clinical trial [RCT], pre–post, case report, and case series) were included. The Cochrane RoB 2.0 tool was used for quality assessment of RCTs. A summary of intervention's effects for each study was provided by calculating standardized mean differences and accompanying 95% confidence interval using random effect model. Weighted mean differences and heterogeneity between studies were assessed using Hedges's method and Cochran's Q test, respectively. Pomegranate can significantly improve hot flashes severity and menopause symptoms and decrease FSH. It significantly improves high‐density lipoprotein but not low‐density lipoprotein, body mass index, and weight. Most of our results are inconclusive, and the small sample sizes and the lack of blinding and randomization have led to an increased risk of bias. Pomegranate can decrease menopause symptoms, but more well‐designed studies, with bigger sample sizes are needed to establish its other clinical benefits for menopausal women.

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“…These results suggest that pomegranate concentrates are ERindependent for both direct and indirect mechanisms to alleviate postmenopausal syndrome (Im et al, 2021;Rowe & Baber, 2021).…”

Section: Discussionmentioning

confidence: 77%

“…Furthermore, pomegranate concentrates do not transactivate ER and do not inhibit E2‐mediated receptor transactivation in HeLa cells. These results suggest that pomegranate concentrates are ER‐independent for both direct and indirect mechanisms to alleviate postmenopausal syndrome (Im et al, 2021; Rowe & Baber, 2021).…”

Section: Discussionmentioning

confidence: 91%