Evaluation of ethanolamine oleate sclerotherapy on the submandibular glands of canines as a potential therapy for sialorrhea

Abbas, Faten; Farid, Rola M; Nada, Ihab; El-Sharnouby, Mohamed M.

doi:10.1016/j.ijporl.2012.11.024

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…It has also been used to successfully sclerose a zygomatic salivary mucocele and two epithelial bone cysts in dogs . Another sclerosing agent, ethanolamine oleate, has been used to experimentally sclerose the submandibular salivary glands of dogs and successfully caused atrophy of the glands in a dose‐dependent manner . Sclerotherapy may have potentially been useful in both cases to sclerose or speed atrophy of the parotid gland, but dosages and concentrations for sclerosing agents are not known for the parotid gland in dogs.…”

Section: Discussionmentioning

confidence: 99%

Enucleation or exenteration in two dogs with previous parotid duct transposition: parotid duct ligation versus reverse parotid duct transposition

Young

Betbeze

Fisher

et al. 2017

Veterinary Ophthalmology

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Two dogs with previous parotid duct transpositions presented with unrelated ocular disease. In both cases, ophthalmic examination revealed the need for enucleation or exenteration. In case 1, systemic coccidioidomycosis was diagnosed with panuveitis and secondary glaucoma of the left eye. In this case, the parotid duct was ligated at the time of enucleation to stop salivary secretions. This dog encountered morbidity in the form of a sialocele that did not resolve for 11 months. In case 2, ultrasound and computed tomography revealed a discrete mass within the left medial orbit that was suspected to arise from the nictitating membrane. A combination of exenteration and parotid duct transposition reversal was performed to avoid morbidity associated with ligation of the parotid duct. The dog encountered no complications from this novel procedure. This case report represents the first report of re-routing a transposed parotid duct from the ventral conjunctival sac back to the mouth at the time of enucleation or exenteration in the dog.

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Section: Discussionmentioning

confidence: 99%

Enucleation or exenteration in two dogs with previous parotid duct transposition: parotid duct ligation versus reverse parotid duct transposition

Young

Betbeze

Fisher

et al. 2017

Veterinary Ophthalmology

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“…Through our qualitative histologic review of the glands, extensive cellular damage and increase in connective tissue was seen in both groups. Our laboratory was not equipped to quantify salivary production in the way utilized by previous investigators [ 14 ], or perform a semi-qualitative and morphometric histological analysis [ 15 ]. However, the results of those researchers allow us to be confident in using gland size and general appearance as an acceptable proxy for salivary gland function [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Percutaneous Salivary Gland Ablation using Ethanol in a Rat Model

Burch

Lubeley

Murakami

2017

JOMR

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ObjectivesSialorrhea is a common health and psychosocial problem for children with neuromuscular dysfunction secondary to a variety of disorders such as cerebral palsy. Current accepted treatments include the injection of botulinum toxin into the submandibular glands for temporary symptom relief. The purpose of this study is to demonstrate the feasibility of percutaneous ethanol injection for longer lasting salivary gland ablation in an animal model. Material and MethodsTwenty rats were used in this study. In each rat, 98% ethanol was injected into the right submandibular gland under ultrasound guidance. No intervention was performed on the left gland, which served as the control. Ten rats were sacrificed and glands evaluated at three weeks, with the remaining 10 rats sacrificed and evaluated at three months. Unpaired, 1-tailed T-tests were used to analyse the data.ResultsEthanol injections induced a significant and sustained reduction in salivary gland size. Treated glands were 41% smaller by mass than untreated controls in the 10 rats sacrificed at three weeks (P < 0.001). Treated glands were 43% smaller by mass than untreated controls in the 10 rats sacrificed at three months (P < 0.001). Qualitative histologic analysis demonstrated extensive parenchymal damage, inflammation, and fibrosis at both three week and three month time points.ConclusionsUsing a rat model, we demonstrated dramatic and sustained submandibular gland damage after percutaneous injection of ethanol.

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Medical Management of Sialorrhea in the Child with Cerebral Palsy

Sabado¹,

Owens²

2018

Cerebral Palsy

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Evaluation of ethanolamine oleate sclerotherapy on the submandibular glands of canines as a potential therapy for sialorrhea

Cited by 4 publications

References 20 publications

Enucleation or exenteration in two dogs with previous parotid duct transposition: parotid duct ligation versus reverse parotid duct transposition

Enucleation or exenteration in two dogs with previous parotid duct transposition: parotid duct ligation versus reverse parotid duct transposition

Percutaneous Salivary Gland Ablation using Ethanol in a Rat Model

Medical Management of Sialorrhea in the Child with Cerebral Palsy

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