Evaluation of evolution of myocardial infarction by serial determinations of serum creatine kinase activity.

Inoue, Michitoshi; Hori, Masatsugu; Fukui, Sugao; Abe, Hiroshi; Minamino, Takazo

doi:10.1136/hrt.39.5.485

Cited by 20 publications

(10 citation statements)

References 21 publications

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“…The median total duration of pain in this series was shorter than reported by others [ 15], This might be explained by the fact that some of the largest infarctions were not in cluded in this study. We have previously reported that the development of Q-and Rwave changes continues for about 18 h in acute myocardial infarction [11].…”

Section: Discussioncontrasting

confidence: 54%

Variability, Prediction and Prognostic Significance of Chest Pain in Acute Myocardial Infarction

et al. 1986

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The variability of chest pain is described in 389 patients with acute myocardial infarction. Whereas 17% were free from severe pain after arrival in hospital, 11% required more than 10 analgesic injections. In 27% of the series analgesics were given more than 24 h after arrival in hospital. Predictors for the severity of chest pain were the rate-pressure product and degree of chest pain soon after arrival in hospital as well as electrocardiographic signs of myocardial infarction at entry. Patients with more severe chest pain had a higher 2-year mortality rate and a higher incidence of ventricular fibrillation and congestive heart failure during hospitalization.

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Section: Discussioncontrasting

confidence: 54%

Variability, Prediction and Prognostic Significance of Chest Pain in Acute Myocardial Infarction

et al. 1986

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“…reported method (Inoue et al, 1977) (Sobel et al, 1972;Norris et al, 1975), there are several problems in its clinical application 0 (Roe and Starmer, 1975). The most important of these is the influence of a release of CK of noncardiac origin on serum CK activity.…”

Section: Fractionmentioning

confidence: 99%

Correlation of ejection fraction and infarct size estimated from the total CK released in patients with acute myocardial infarction.

Hori¹,

Inoue²,

Fukui³

et al. 1979

Heart

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SUMMARY In order to investigate the relation between infarct size in acute myocardial infarction and left ventricular ejection fraction early after recovery, total creatine kinase released was calculated by the modified method of Sobel et al. (1972) from the serial determinations of serum CK activity; left ventriculography and selective coronary arteriography were performed at a mean of 2 months after the onset of infarction in 34 patients with acute myocardial infarction. Of 34 patients, 32 (94%) had left ventricular asynergy. In 21 patients with akinesis and/or dyskinesis, a significant correlation was found between the extent of thenon-contractingsegmentof theleft ventricle and left ventricular ejection fraction, indicating that the extent of the non-contracting segment contributes largely to reduction of ejection fraction in patients with myocardial infarction.A close inverse correlationwas also observed between theinfarct size and ejection fraction after anterior and after inferior infarction, though cardiac index was maintained over 2-0 1/min per m2 in all except 3 patients. The ejection fraction in patients with anterior myocardial infarction was lower than in those patients with inferior myocardial infarction with comparable values of total CK released. This was true even after exclusion of 6 patients with proximal right coronary artery lesions who might have had right ventricular necrosis as well as left, indicating that left ventricular function after infarction depends in part on the site of the infarct.Since Harrison (1965) In the present study, we attempted to estimate infarct size by calculating the total CK released from infarcted myocardium using the method of Sobel et al. (1972)

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“…In previous studies, conflicting reports have been obtained regarding the correlation between the duration of enzyme release and infarct size. Mathey et al (1975) did not find a difference in infarct size between patients with short and long duration of CK release, but Inoue et al (1977) found a good correlation between duration of CK release and cumulative CK activity in serum.…”

Section: Discussionmentioning

confidence: 99%

Time lapse from estimated onset of acute myocardial infarction to peak serum enzyme activity

Herlitz

Hjalmarson

Waldenström

1984

Clinical Cardiology

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In 581 patients with acute myocardial infarction (MI), the time lapse from estimated onset of infarction to estimated peak serum (S) enzyme activity was evaluated. Heat‐stable lactate dehydrogenase (LD; E.C. 1.1.1.27) was analyzed every 12 h for 48–108 h after arrival in hospital (n =581) and creatine kinase (CK; E.C. 2.7.3.2.; n=224), and creatine kinase subunit B (CK‐B; n=211) were analyzed every 6 h for 48 h. Peak S‐LD was observed between 14 and 110 h after estimated onset of MI (mean 46.6±0.6 h), peak S‐CK was observed between 8 and 58 h (mean 25.0±0.6 h), and peak S‐CK‐B was also observed between 8 and 58 h (mean 22.8 ±0.7 h) after onset. In 86% of patients, peak LD was reached within 60 h after onset of MI, in 78%, peak CK was reached within 30 h, and in 82%, peak CK‐B was observed within 30 h after onset of MI. A weak correlation was found between duration of pain and time lapse to S peak enzyme activity (r=0.25–0.27; p<0.001), while there was no correlation between S peak activity and time lapse from onset of MI to S peak activity. It is concluded, that although in the majority of patients with MI, peak serum‐enzyme activity is reached within a predictable amount of time after estimated onset of MI there is wide variation, difficult to establish from the clinical course, among individual patients.

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Evaluation of evolution of myocardial infarction by serial determinations of serum creatine kinase activity.

Cited by 20 publications

References 21 publications

Variability, Prediction and Prognostic Significance of Chest Pain in Acute Myocardial Infarction

Variability, Prediction and Prognostic Significance of Chest Pain in Acute Myocardial Infarction

Correlation of ejection fraction and infarct size estimated from the total CK released in patients with acute myocardial infarction.

Time lapse from estimated onset of acute myocardial infarction to peak serum enzyme activity

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