Evaluation of Exhaled Nitric Oxide in Patients Undergoing Myocardial Revascularization with Cardiopulmonary Bypass

Abstract

The reduction of exhaled NO after CPB observed in this study does not confirm the role of this molecule as a marker of pulmonary lesion. However, the different degrees of pulmonary parenchymal collapse, the method used to collect the data, and the drugs, among others, could have contributed for this reduction.

Perioperative changes in exhaled nitric oxide during oesophagectomy

“…Correlation of NO with haemodynamic and biochemical parameters recorded at the time of breath sampling demonstrated significant trends for systolic blood pressure (ρ-0.276, P=0.006), lactate (−0.284, P=0.007), pH (ρ0.238, P=0.020), and HCO O-POSSUM = Physiological and Operative Severity Score for the enUmeration of mortality and morbidity developed specifically for use in esophagogastric surgery. 6 One patient who developed pneumonia was also diagnosed as having ARDS/ALI. A-a O 2 gradient, alveolar-arterial oxygen gradient.…”

“…In previous studies NO has been investigated in patients undergoing cardiopulmonary bypass (CPB) as well as other major surgical procedures. Six studies investigating the effect of CPB on exhaled NO levels reported a fall in NO after this intervention [2][3][4][5][6][7].…”

“…The majority of these studies were related to cardiac surgery and have examined the influence of cardiopulmonary bypass on NO levels in exhaled breath, although often with conflicting results. Whilst a significant proportion of these studies demonstrated either a fall [2][3][4][5][6][7] or no change [8][9][10][11] in the levels of exhaled NO after cardiopulmonary bypass, a minority of studies showed an increase in this biomarker [9,12,13]. Marczin et al likewise reported that the exhaled breath of lung transplant recipients showed either no change or a fall in NO after surgery [11].…”