Evaluation of Expression Level of Apolipoprotein M as a Diagnostic Marker for Primary Venous Thromboembolism

Abstract

Recently, decreased levels of apolipoprotein M (ApoM) were shown to be associated with higher risk of recurrent venous thromboembolism (VTE) in male patients. However, the role of ApoM in primary VTE is unknown. We aimed in our study to analyze the plasma levels of ApoM in patients with VTE in order to evaluate the diagnostic importance of ApoM in primary VTE. A total of 357 patients with suspected first episode of VTE were recruited prospectively in the SCORE study. Plasma samples from 307 patients were available for quantifying the plasma levels of ApoM in patients with VTE using sandwich enzyme-linked immunosorbent assay method. Among the whole population, plasma levels (mean [standard deviation]) of ApoM were not significantly different between patients with VTE (0.72 [0.20]) and non-VTE patients (0.72 [0.16]), P = .99. Similarly, in regression analyses, no significant association of ApoM plasma levels with the risk of VTE was found on univariate (odds ratio [OR] =1.0, 95% confidence interval [CI] 0.21-4.84, P = .99) and multivariate analysis (OR = 1.25, 95% CI = 0.19-8.34, P = .819) after adjusting for age, body mass index, and smoking. Moreover, results did not differ significantly after stratification of data according to sex ( P > .05). In this study, our results do not suggest a diagnostic role for ApoM plasma levels in patients with primary VTE. Moreover, the current study suggests that role of ApoM as a risk factor may differ for primary VTE and recurrent VTE in male patients.

Identification of hub genes and key pathways in pediatric Crohn’s disease using next generation sequencing and bioinformatics analysis

“…These type 1 diabetes mellitus responsible genes might be important participant in CD. IL1B [742], C4BPB [743], ADM (adrenomedullin) [744], GDF15 [745], IL1RN [746], SOD2 [747], TLR2 [748], VWF (von Willebrand factor) [749], APOE (apolipoprotein E) [750], IL6 [751], CCL4 [752], AQP5 [753], SELP (selectin P) [754], PLAU (plasminogen activator, urokinase) [755], MASP1 [756], MPO (myeloperoxidase) [757], MMP10 [758], EMILIN2 [759], ACE2 [760], F10 [761], ACE (angiotensin I converting enzyme) [762], F11 [763] and APOM (apolipoprotein M) [764] participates in the occurrence and development of coagulation and fibrinolysis. These coagulation and fibrinolysis responsible genes might be relevant to the pathological basis of CD susceptibility.…”

Mitochondrial related genome-wide Mendelian randomization identifies putatively causal genes for multiple cancer types

“… 10 In total, 931,304 SNPs were selected corresponding to 2550 mitochondrial-related DNA methylation CpG sites. MR cis -pQTL instruments for genetic variants associated with the expression of mitochondrial-related proteins were selected from five proteome datasets, 13 , 14 , 15 , 16 , 17 and 23 SNPs that were robustly associated with 23 mitochondrial-related protein expressions were selected. All SNPs included in the initial analysis had at least a suggestive P snp-mitodys <5 × 10 −8 .…”