“…However, excessive fluid volume expansion can be harmful, especially in patients with heart disease. As patients with acute circulatory failure do not usually respond to fluid loading by increasing their CO, numerous studies [1][2][3] have been conducted to develop tests that predict "fluid responsiveness". Although static indices, such as central venous pressure and pulmonary capillary wedge pressure, have been traditionally used for assessing patients' volume status, these indices have poor reliability for identifying fluid responders [4].…”